[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612431":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":32,"centralContacts":37,"locations":46,"responsibleParty":67,"collaborators":31,"id":71,"slug":72,"hasResults":73,"nctId":74,"briefTitle":75,"officialTitle":76,"acronym":31,"eligibilityCriteria":77,"healthyVolunteers":78,"sex":79,"minAge":80,"maxAge":81,"enrollmentInfo":82,"targetDuration":31,"studyType":85,"phases":86,"briefSummary":88,"conditions":89,"keywords":91,"overallStatus":49,"whyStopped":31,"lastUpdateSubmitDate":98,"lastUpdatePostDateStruct":99,"startDateStruct":102,"completionDateStruct":104,"leadSponsor":106,"locationsCount":107},{"fullName":5,"class":6},"Istanbul Physical Medicine Rehabilitation Training and Research Hospital","OTHER_GOV",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Postmenapausal femoral osteoporosis","OTHER","Subjects with diagnosed femoral osteoporosis will be in this arm. Femoral osteoporosis is defined as T-scores of -2.5 or lower in femoral neck or total femur obtained in dual energy x-ray absorptiometry.\n\nSubjects will have their H-reflex amplitude measured in 6 different settings and will be applied 10 seconds whole-body vibration in 4 different frequencies to measure bone mroregulation reflex.",[13,14],"Diagnostic Test: H-reflex","Diagnostic Test: Bone myoregulation reflex",{"label":16,"type":10,"description":17,"interventionNames":18},"Healthy control","Subjects who do not have osteoporosis or osteopenia will be in this arm. Subjects in this group will have L1-L4, L2-L4, femoral neck and total femur T-scores of greater than -1 obtained in dual energy x-ray absorptiometry.\n\nSubjects will have their H-reflex amplitude measured in 6 different settings and will be applied 10 seconds whole-body vibration in 4 different frequencies to measure bone mroregulation reflex.",[13,14],[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DIAGNOSTIC_TEST","H-reflex","H-reflex will be measured during 5 different mechanical loads and whole body vibration.",[16,9],[26],"Hoffmann's reflex",{"type":21,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"Bone myoregulation reflex","Bone myoregulation reflex will be measured by applying 10 seconds whole body vibration of 4 different frequencies.",[16,9],null,[33],{"name":34,"affiliation":35,"role":36},"İlhan Karacan, Prof. Dr.","stanbul Physical Medicine Rehabilitation Training and Research Hospital","STUDY_CHAIR",[38,43],{"name":39,"role":40,"phone":41,"phoneExt":31,"email":42},"Fuat Orhun Alayoğlu, Attending doctor","CONTACT","+905348431984","f.orhunalayoglu@gmail.com",{"name":34,"role":40,"phone":44,"phoneExt":31,"email":45},"+905327005361","mdkaracanilhan@gmail.com",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":31,"cosmosGeoPoint":54,"geoPoint":59,"contacts":60},"Istanbul Physical Medicine Rehabilitation Training & Research Hospital","RECRUITING","Bahçelievler","Istanbul","34180","Turkey (Türkiye)",{"type":55,"coordinates":56},"Point",[57,58],28.8598,41.00231,{"lat":58,"lon":57},[61,64],{"name":62,"role":40,"phone":63,"phoneExt":31,"email":42},"Fuat Orhun Alayoğlu, Attending Doctor","05348431984",{"name":34,"role":40,"phone":65,"phoneExt":31,"email":66},"0532 700 5361","mdilhankaracan@gmail.com",{"type":68,"investigatorFullName":69,"investigatorTitle":70,"investigatorAffiliation":5,"oldNameTitle":31,"oldOrganization":31},"PRINCIPAL_INVESTIGATOR","Fuat Orhun Alayoglu","Attending physician","100612431","effect-of-mechanical-loading-and-bone-loss-on-motor-neuron-activity-h-reflex-relationship-100612431",false,"NCT07253493","Effect of Mechanical Loading and Bone Loss on Motor Neuron Activity-H-Reflex Relationship","The Effect of Mechanical Loading and Bone Loss on the Relationship Between Motor Neuron Pool Activity and H-Reflex Amplitude","Inclusion Criteria:\n\n* Being in the postmenopausal period\n* For the osteoporosis group: having femoral osteoporosis (femoral neck or total femur T-score ≤ -2.5)\n* For the control group: having no osteoporosis or osteopenia (femoral neck and total femur T-scores \\> -1, and L1-L4 and L2-L4 T-scores \\> -1)\n* Being a volunteer\n\nExclusion Criteria:\n\n* Receiving osteoporosis treatment\n* Having a peripheral or central nervous system disorder (e.g., stroke, polyneuropathy, radiculopathy, entrapment neuropathy, etc.)\n* Having acquired or hereditary muscle diseases (myopathies)\n* Having active painful lower extremity pathologies (e.g., osteoarthritis, inflammatory joint diseases, etc.)\n* Having cardiac arrhythmias\n* Having a history of other metabolic bone diseases\n* Having skin lesions at the electrode placement sites on the lower extremities\n* Being older than 65 years",true,"FEMALE","18 Years","65 Years",{"count":83,"type":84},24,"ESTIMATED","INTERVENTIONAL",[87],"NA","Weight-bearing exercises (e.g., running, jumping, whole-body vibration) are widely practiced due to their beneficial effects on bone development and their role in the prevention and treatment of osteoporosis. However, the underlying neuroregulatory mechanisms responsible for these positive effects have not yet been fully understood. Two main neuromodulatory mechanisms have been proposed in the literature: (i) spinal reflexes originating from muscle spindles (stretch reflex, tonic vibration reflex), and (ii) the bone myoregulation reflex (BMR) based on load-sensitive osteocytes.\n\nIt is well established that increased voluntary contraction and the associated rise in background EMG activity, that is, motor neuron pool activity, enhance muscle spindle-based reflex responses (such as the H-reflex and tendon reflex). In contrast, it has been demonstrated that the H-reflex is suppressed during bone-loading activities such as single-leg stance, jumping, or whole-body vibration.\n\nThis study is based on two hypotheses:\n\n* As mechanical loading increases, Ia inhibitory effects intensify, leading to greater H-reflex suppression.\n* During whole-body vibration, the H-reflex is suppressed due to Ia inhibition.\n\nIf this inhibition originates from load-sensitive receptors-osteocytes-and thus from the BMR, then in osteoporosis, where osteocyte number and function are reduced, H-reflex suppression will be diminished.\n\nThe aim of this research is to test these hypotheses. Confirmation of these assumptions would suggest that reflex control during weight-bearing exercise occurs predominantly through osteocyte-mediated BMR mechanisms rather than muscle spindle-based mechanisms such as the stretch or tonic vibration reflex.",[90],"Osteoporosis Postmenopausal",[22,92,93,94,95,96,97],"osteoporosis","whole-body vibration","mechanical load","osteocyte","bone myoregulation reflex","background EMG activity","2025-11-19",{"date":100,"type":101},"2025-11-28","ACTUAL",{"date":103,"type":101},"2025-11-18",{"date":105,"type":84},"2026-04",{"name":5,"class":6},1]