[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100576947":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":10,"centralContacts":29,"locations":39,"responsibleParty":52,"collaborators":10,"id":55,"slug":56,"hasResults":57,"nctId":58,"briefTitle":59,"officialTitle":60,"acronym":10,"eligibilityCriteria":61,"healthyVolunteers":62,"sex":63,"minAge":64,"maxAge":10,"enrollmentInfo":65,"targetDuration":10,"studyType":68,"phases":10,"briefSummary":69,"conditions":70,"keywords":74,"overallStatus":41,"whyStopped":10,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"Kocaeli City Hospital","OTHER_GOV",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Flow Controlled Mechanical Ventilation (FCV)",null,"Controlled ventilation parameters and hemodynamic and respiratory values (systolic pressure, diastolic pressure, peak heart rate, peripheral oxygen saturation, fraction of inspired oxygen (FiO2)), and Bispectral Index monitoring (BIS) values in the patient's preferred FCV mode will be recorded. Ablation lesion parameters including mean ablation time per lesion, mean contact force, mean impedance drop, mean ablation index, and procedural characteristics including total procedure time, total ablation time, and total RF time will also be recorded. Clinical outcomes, including freedom from all atrial arrhythmias and short and long-term procedural complications, will also be recorded at routine patient follow-up.",[13],"Procedure: Radiofrequency Ablation with FCV.",{"label":15,"type":10,"description":16,"interventionNames":17},"Volume Controlled Mechanical Ventilation (VCV)","Controlled ventilation parameters and hemodynamic and respiratory values (systolic pressure, diastolic pressure, peak heart rate, peripheral oxygen saturation, fraction of inspired oxygen (FiO2)), and Bispectral Index monitoring (BIS) values in the patient's preferred VCV mode will be recorded. Ablation lesion parameters including mean ablation time per lesion, mean contact force, mean impedance drop, mean ablation index, and procedural characteristics including total procedure time, total ablation time, and total RF time will also be recorded. Clinical outcomes, including freedom from all atrial arrhythmias and short and long-term procedural complications, will also be recorded at routine patient follow-up.",[18],"Procedure: Radiofrequency Ablation with VCV.",[20,25],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":10},"PROCEDURE","Radiofrequency Ablation with FCV.","Treatment of atrial fibrillation patients with radiofrequency ablation under general anesthesia with Flow Controlled Mechanical Ventilation (FCV).",[9],{"type":21,"name":26,"description":27,"armGroupLabels":28,"otherNames":10},"Radiofrequency Ablation with VCV.","Treatment of atrial fibrillation patients with radiofrequency ablation under general anesthesia with Volume Controlled Mechanical Ventilation (VCV).",[15],[30,35],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},"Merve Yazici Kara","CONTACT","+90 533 686 0156","merreset@hotmail.com",{"name":36,"role":32,"phone":37,"phoneExt":10,"email":38},"Nurseda Dundar","+90 530 510 2245","d.nurseda@hotmail.com",[40],{"facility":5,"status":41,"city":42,"state":10,"zip":10,"country":43,"countryCode":10,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Kocaeli","Turkey (Türkiye)",{"type":45,"coordinates":46},"Point",[47,48],27.51145,39.62497,{"lat":48,"lon":47},[51],{"name":31,"role":32,"phone":33,"phoneExt":10,"email":34},{"type":53,"investigatorFullName":31,"investigatorTitle":54,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Principal Investigator","100576947","effect-of-mechanical-ventilation-on-radiofrequency-ablation-in-atrial-fibrillation-100576947",false,"NCT06791915","Effect of Mechanical Ventilation on Radiofrequency Ablation in Atrial Fibrillation","The Effect of Mechanical Ventilation on Radiofrequency Ablation in The Treatment of Atrial Fibrillation.","Inclusion Criteria:\n\n* Diagnosed with atrial fibrillation\n* planned to receive radiofrequency ablation treatment under general anesthesia\n* all patients over 18 years of age\n\nExclusion Criteria:\n\n\\- Patients undergoing ablation under sedation and\u002For local anesthesia",true,"ALL","18 Years",{"count":66,"type":67},50,"ESTIMATED","OBSERVATIONAL","Radiofrequency ablation (RFA) for atrial fibrillation (AF) is performed under general anesthesia. The success of the procedure depends on the safe contact of the catheter electrode with the myocardium. Movement of the catheter tip due to respiratory changes can result in inadequate lesion formation and AF recurrence.\n\nThe success of AF ablation depends on the adequacy of energy delivered to the myocardium and the durability of pulmonary vein isolation (PVI). Poor energy delivery and tissue heating during ablation are a major cause of procedural failure in RFA. To improve the success of the PVI procedure, efforts are underway to optimize catheter stability and contact force. However, catheter force and stability are influenced by respiration-induced thoracic motion, highlighting the importance of controlled breathing for further optimization. Fluoroscopy and ablation times during electroanatomic mapping-guided AF ablations improved with controlled mechanical ventilation. General anesthesia improved catheter contact.\n\nLow tidal volume, high respiratory rate (FCV), pressure controlled mechanical ventilation (PCV), volume controlled mechanical ventilation (VCV), pressure controlled volume assured mechanical ventilation (PRVC) can be used in investigators' hospital. The literature offers no definitive proof that one ablation procedure is superior to another.",[71,72,73],"Radiofrequency Ablation","Atrial Fibrillation","Mechanical Ventilation",[72,75,76],"Ablation","general anesthesia","2025-01-23",{"date":79,"type":80},"2025-01-24","ACTUAL",{"date":82,"type":80},"2025-01-01",{"date":84,"type":67},"2025-08-01",{"name":5,"class":6},1]