[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100521336":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":31,"locations":38,"responsibleParty":56,"collaborators":18,"id":59,"slug":60,"hasResults":61,"nctId":62,"briefTitle":63,"officialTitle":64,"acronym":65,"eligibilityCriteria":66,"healthyVolunteers":61,"sex":67,"minAge":68,"maxAge":69,"enrollmentInfo":70,"targetDuration":18,"studyType":73,"phases":74,"briefSummary":76,"conditions":77,"keywords":80,"overallStatus":41,"whyStopped":18,"lastUpdateSubmitDate":84,"lastUpdatePostDateStruct":85,"startDateStruct":88,"completionDateStruct":90,"leadSponsor":92,"locationsCount":93},{"fullName":5,"class":6},"Universidad Complutense de Madrid","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Test group","EXPERIMENTAL","According to randomization, test group patients will receive MOPs at the beginning of the orthodontic therapy and at every other orthodontic recall appointment.",[13],"Procedure: Micro-ostoperforations (MOPs)",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group","NO_INTERVENTION","No MOPs performed at any stage of the orthodontic therapy",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","Micro-ostoperforations (MOPs)","3 MOPs will be performed in the bone next to the root of the experimental tooth. MOPs will be performed using the Excellerator® (Propel Orthodontics, Denstply, Sirona)",[9],[26,29],{"name":27,"affiliation":5,"role":28},"Conchita Martin, Prof","PRINCIPAL_INVESTIGATOR",{"name":30,"affiliation":5,"role":28},"Elena Figuero, Prof",[32,36],{"name":27,"role":33,"phone":34,"phoneExt":18,"email":35},"CONTACT","+343941901","mariacom@ucm.es",{"name":30,"role":33,"phone":34,"phoneExt":18,"email":37},"efigueruiz@odon.ucm.es",[39],{"facility":40,"status":41,"city":42,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"Faculty of Odontology, University Complutense Madrid","RECRUITING","Madrid","28040","Spain","ES",{"type":47,"coordinates":48},"Point",[49,50],-3.70256,40.4165,{"lat":50,"lon":49},[53,55],{"name":27,"role":33,"phone":54,"phoneExt":18,"email":35},"+34 91 3941901",{"name":30,"role":33,"phone":54,"phoneExt":18,"email":37},{"type":28,"investigatorFullName":57,"investigatorTitle":58,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"Concepción Martín Alvaro","Professor in Orthodontics","100521336","effect-of-mops-during-orthodontic-movement-in-periodontitis-patients-100521336",false,"NCT06068270","Effect of MOPs During Orthodontic Movement in Periodontitis Patients","Randomized Clinical Trial on the Effect of Micro-osteoperforations (MOPs) During Intrusion of Flared Upper Anterior Teeth in Stage IV Periodontitis Patients","MOPorthoperi","Inclusion Criteria:\n\nPatients will be included if agreeing to undertake combined periodontal and orthodontic therapy following the clinical practice guideline of stage IV periodontitis patients, and fulfilling the following criteria:\n\n* adult patients older than 18-year-old;\n* systemically healthy (see exclusion criteria);\n* diagnosed as stage IV (Papapanou et al., 2018) case-type 2 (Herrera et al. 2022) periodontitis;\n* the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabonny component \\\u003C5mm) (experimental teeth);\n* in need of orthodontic therapy.\n\nExclusion Criteria:\n\n* systemic diseases (diabetes mellitus, obesity, cardiovascular diseases);\n* any medication that could affect the level of inflammation, (such as chronic antibiotics, phenytoin, cyclosporin, anti-inflammatory drugs, systemic corticosteroids, or calcium channel blockers);\n* pregnant or lactating woman;\n* inability to respond questions or to attend follow-up visits;\n* extreme skeletal malocclusions requiring orthognathic surgery;\n* patients smoking more than 10 cigarettes\u002Fday; and\n* the presence of PD greater or equal to 5mm with BOP after step 3 of periodontal therapy","ALL","18 Years","80 Years",{"count":71,"type":72},28,"ESTIMATED","INTERVENTIONAL",[75],"NA","Micro-osteoperforations (MOPs) cause cortical bone injuries and consequently increase the expression of inflammatory mediators, allowing for increased bone and periodontal ligament remodeling associated with orthodontic movement. It remains unclear the effect of orthodontic intrusion combined with MOPs application on teeth with reduced periodontium. The general objective will be to determine the efficacy of MOPs during orthodontic tooth movement (OTM) in terms of periodontal and orthodontic outcomes in stage IV periodontitis patients, case type 2 with pathological tooth migration (PTM), characterized the presence of at least one flared tooth of the upper-anterior sextant with an intrabony defect (intrabony component \\\u003C5mm)",[78,79],"Stage IV Periodontitis","Orthodontic Tooth Movement",[81,82,83],"Stage IV periodontitis","Orthodontic tooth movement","Micro-osteoperforations","2025-03-24",{"date":86,"type":87},"2025-03-27","ACTUAL",{"date":89,"type":87},"2023-12-15",{"date":91,"type":72},"2026-01",{"name":5,"class":6},1]