[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100537410":3},{"organization":4,"armGroups":7,"interventions":15,"overallOfficials":21,"centralContacts":26,"locations":36,"responsibleParty":61,"collaborators":21,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":21,"eligibilityCriteria":69,"healthyVolunteers":70,"sex":71,"minAge":72,"maxAge":73,"enrollmentInfo":74,"targetDuration":21,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":86,"overallStatus":39,"whyStopped":21,"lastUpdateSubmitDate":91,"lastUpdatePostDateStruct":92,"startDateStruct":95,"completionDateStruct":97,"leadSponsor":99,"locationsCount":100},{"fullName":5,"class":6},"The Affiliated Hospital of Xuzhou Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Comparison of T2DM susceptibility gene expression between newly diagnosed T2DM patients and controls","EXPERIMENTAL","To determine the effect of gene mutations on the susceptibility of T2DM by comparing the expression levels of T2DM susceptibility genes in newly diagnosed T2DM patients and controls.",[13,14],"Drug: Fresh normal pancreatic tissues or adjacent tissues of pancreatic cancer were collected from controls and T2DM patients without hypoglycemic drugs","Drug: Fresh blood samples were collected from healthy subjects and T2DM patients without hypoglycemic drugs",[16,22],{"type":17,"name":18,"description":19,"armGroupLabels":20,"otherNames":21},"DRUG","Fresh normal pancreatic tissues or adjacent tissues of pancreatic cancer were collected from controls and T2DM patients without hypoglycemic drugs","Compared with newly diagnosed T2DM patients, healthy subjects in the control group had normal levels of blood glucose, lipids, glycated hemoglobin levels, etc. Fresh normal pancreatic tissues or adjacent tissues of pancreatic cancer were collected before taking antidiabetic drugs in both groups.",[9],null,{"type":17,"name":23,"description":24,"armGroupLabels":25,"otherNames":21},"Fresh blood samples were collected from healthy subjects and T2DM patients without hypoglycemic drugs","The newly diagnosed T2DM group should not have taken antidiabetic drugs and meet the diagnosis of T2DM. Fresh blood samples were collected before medication for detection.\n\nIn the control group (healthy subjects), the indicators of physical examination were within the normal range and no hypoglycemic drugs were taken. Similarly, fresh blood samples should be taken for testing.",[9],[27,32],{"name":28,"role":29,"phone":30,"phoneExt":21,"email":31},"Tao Wang, Ph.D","CONTACT","13815344640","misswt2011@126.com",{"name":33,"role":29,"phone":34,"phoneExt":21,"email":35},"Xiaoxing Yin, Ph.D","13605218523","yinxx@xzmc.edu.cn",[37],{"facility":38,"status":39,"city":40,"state":21,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"China, Jiangsu, Department of Endocrinology","RECRUITING","Xuzhou","221006","China","CN",{"type":45,"coordinates":46},"Point",[47,48],117.28386,34.20442,{"lat":48,"lon":47},[51,55,58],{"name":52,"role":29,"phone":53,"phoneExt":21,"email":54},"Hongwei Ling, MD","18052268607","linghongwei@medmail.com.cn",{"name":56,"role":57,"phone":21,"phoneExt":21,"email":21},"Renguo Chen, MD","PRINCIPAL_INVESTIGATOR",{"name":59,"role":60,"phone":21,"phoneExt":21,"email":21},"Yuhan Huang, MD","SUB_INVESTIGATOR",{"type":62,"investigatorFullName":21,"investigatorTitle":21,"investigatorAffiliation":21,"oldNameTitle":21,"oldOrganization":21},"SPONSOR","100537410","effect-of-mutations-in-t2dm-susceptibility-genes-on-the-expression-of-susceptibility-genes-in-patients-with-t2dm-and-controls-100537410",false,"NCT06277466","Effect of Mutations in T2DM Susceptibility Genes on the Expression of Susceptibility Genes in Patients With T2DM and Controls","Department of Pharmacy, the Affiliated Hospital of Xuzhou Medical University","Inclusion Criteria:\n\n1. no drug therapy; 25 to 70 years old; Hemoglobin A1c (HbA1c) 7%-12%; BMI 20-35 kg\u002Fm2; Stable body weight (≤10% change within 3 months)（For newly diagnosed patients with T2DM）.\n2. 25 to 60 years old; BMI 19-26 kg\u002Fm2; in good health, with no abnormalities of motor system, digestive system, respiratory system, urogenital system, blood system, circulatory system, nervous\u002Fmental system, endocrine system, etc（For healthy subjects）.\n3. 20-80 years old; surgical resection of part or all of the pancreas; pancreatic lesions confirmed by enhanced CT or magnetic resonance (MR) examination or confirmed by intraoperative and postoperative pathology（For the patients in general surgical）.\n\nExclusion Criteria:\n\n1. had taken antidiabetic drugs;\n2. had a history of pancreatic surgery;\n3. Complicated with severe organ lesions;\n4. Long-term use of drugs that affect pancreatic function.",true,"ALL","25 Years","70 Years",{"count":75,"type":76},300,"ESTIMATED","INTERVENTIONAL",[79],"NA","In this study, investigators wanted to determine the effect of T2DM susceptibility gene mutations on self-expression.\n\nParticipants (T2DM patients and controls) were recruited to identify genotypes and detect the levels of T2DM susceptibility genes expression in the fresh peripheral plasma. The normal pancreatic tissues or adjacent tissues of pancreatic cancer were also collected to identify the expression differences of T2DM susceptibility genes under different genotypes.",[82,83,84,85],"Type 2 Diabetes Mellitus","Gene Polymorphisms","Genetic Mutations","Susceptibility, Genetic",[87,88,89,90],"T2DM","gene polymorphism","susceptibility gene","genetic mutations","2024-02-25",{"date":93,"type":94},"2024-02-28","ACTUAL",{"date":96,"type":94},"2024-01-01",{"date":98,"type":76},"2028-01-31",{"name":5,"class":6},1]