[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643198":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":10,"centralContacts":24,"locations":33,"responsibleParty":46,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":55,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":10,"enrollmentInfo":59,"targetDuration":62,"studyType":63,"phases":10,"briefSummary":64,"conditions":65,"keywords":10,"overallStatus":36,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"First Affiliated Hospital of Ningbo University","NETWORK",[8,12,15,18,21],{"label":9,"type":10,"description":11,"interventionNames":10},"Immunometabolic differences between DS-TB and MDR-TB",null,"Using a prospective, single-center, observational study design, it is planned to enroll 30 patients divided into drug-susceptible tuberculosis and multidrug-resistant tuberculosis. CyTOF technology was used to analyze the differences in immune subsets and metabolic functions.",{"label":13,"type":10,"description":14,"interventionNames":10},"To assess the effect of immune status on NTM","A total of 15 patients over the age of 18 diagnosed with non-tuberculous mycobacteria were included, and peripheral blood samples were collected after 2 months of treatment to analyze the changes in immune status and metabolic status of non-tuberculous mycobacterial patients in healthy people.",{"label":16,"type":10,"description":17,"interventionNames":10},"Significance of studying the immunometabolic status of tuberculous pleurisy","A total of 20 patients over the age of 18 diagnosed with tuberculous pleurisy were included in the plan, divided into high-symptom and low-symptomatic groups, and pleural fluid and peripheral blood samples were collected before and after treatment to analyze the changes in their immune status and metabolic status before and after treatment.",{"label":19,"type":10,"description":20,"interventionNames":10},"Study of immunometabolic status in different states of tuberculosis","A total of 15 patients over the age of 18 diagnosed with active pulmonary tuberculosis and 10 patients with latent pulmonary tuberculosis were enrolled, and peripheral blood samples were collected before and after treatment to analyze the changes in their immune status and metabolic status before and after treatment.",{"label":22,"type":10,"description":23,"interventionNames":10},"A study of exhaled air condensate in NTM patients versus CAP patients","A total of 30 patients over the age of 18 diagnosed with nontuberculous mycobacteria and 30 healthy or community pneumonia patients were enrolled, and their exhaled air condensate was collected before or within 2 weeks after treatment to analyze its composition.",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"Chao Cao","CONTACT","+86-0574-87089878","caodoctor@163.com",{"name":31,"role":27,"phone":28,"phoneExt":10,"email":32},"Shiyi He","shiyihii@163.com",[34],{"facility":35,"status":36,"city":37,"state":10,"zip":10,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":10},"The First Affiliated Hospital of Ningbo University","RECRUITING","Ningbo","China","CN",{"type":41,"coordinates":42},"Point",[43,44],121.54945,29.87819,{"lat":44,"lon":43},{"type":47,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Chao Cao, Ph.D.","Principal Investigator","100643198","effect-of-mycobacterial-infection-on-immune-status-100643198",false,"NCT07638670","Effect of Mycobacterial Infection on Immune Status","EMIIS","Inclusion Criteria and Exclusion Criteria:\n\nInclusion Criteria：\n\n1. Age ≥ 18 years, all genders and races accepted.\n2. Patients with active pulmonary tuberculosis diagnosed clinically or by bronchoscopy within less than 1 week.\n3. Patients with latent tuberculosis infection (positive T-SPOT test but no evidence of active tuberculosis infection).\n4. Patients with tuberculous pleurisy with onset within less than 1 week.\n5. Voluntarily join this study and sign the informed consent form.\n6. Patients whose drug susceptibility test or NGS results indicate resistance to at least isoniazid and rifampicin (MDR-TB).\n7. Patients whose drug susceptibility test or NGS results indicate sensitivity to first-line anti-tuberculosis drugs.\n8. Patients whose drug susceptibility test or NGS results indicate resistance to only one anti-tuberculosis drug.\n9. Patients with newly identified nontuberculous mycobacterial infection (within less than 1 week) by sputum culture or NGS.\n\nExclusion Criteria：\n\n1. Immunosuppressive conditions including HIV infection, long-term use (\\>1 month) of immunosuppressive agents or corticosteroids, severe malnutrition, etc.\n2. Concurrent other lung diseases, severe liver or kidney dysfunction, severe endocrine diseases, hematological diseases, or malignant tumors that may affect the study outcomes.\n3. Patients with diabetes mellitus.\n4. Pregnant or lactating women.\n5. Patients unable or unwilling to provide informed consent, or with poor compliance.","ALL","18 Years",{"count":60,"type":61},120,"ESTIMATED","60 Days","OBSERVATIONAL","This study, titled \"Effect of Mycobacterial Infection on Immune Status\" (EMIIS), investigates the immune-driven mechanisms of mycobacterial infections, focusing on the dynamic immune characteristics of multidrug-resistant tuberculosis (MDR-TB), nontuberculous mycobacterial (NTM) infections, and tuberculous pleurisy. Mycobacterial infections (including the Mycobacterium tuberculosis complex and nontuberculous mycobacteria) remain a major global public health threat. EMIIS is a single-center, randomized, single-blind,prospective study. The study recruited 120 participants, divided into groups of healthy individuals\u002Fcommunity-acquired pneumonia patients, active pulmonary tuberculosis patients, latent tuberculosis infection patients, tuberculous pleurisy patients, and nontuberculous mycobacteria patients. Blood samples were collected from all groups within 3 days before treatment and 2-3 months after treatment. Pleural effusion samples were additionally collected from the tuberculous pleurisy group within 3 days before treatment and 2 months after treatment. Exhaled breath condensate (EBC) was collected from the nontuberculous mycobacteria group. Utilizing mass cytometry (CyTOF) and multi-dimensional indicators, the study aims to elucidate the immune-driven mechanisms of mycobacterial infections and provide new strategies for individualized treatment.",[66],"Tuberculosis","2026-06-04",{"date":69,"type":70},"2026-06-10","ACTUAL",{"date":72,"type":70},"2025-07-09",{"date":74,"type":61},"2026-07-20",{"name":5,"class":6},1]