[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100584992":3},{"organization":4,"armGroups":7,"interventions":25,"overallOfficials":45,"centralContacts":46,"locations":45,"responsibleParty":52,"collaborators":45,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":45,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":45,"studyType":69,"phases":70,"briefSummary":72,"conditions":73,"keywords":45,"overallStatus":75,"whyStopped":45,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":45},{"fullName":5,"class":6},"Cairo University","OTHER",[8,14,19],{"label":9,"type":10,"description":11,"interventionNames":12},"8.6% nano-hydroxy apatite crystals varnish.","EXPERIMENTAL","Intervention group (1)",[13],"Drug: nano hydroxy apatite varnish",{"label":15,"type":10,"description":16,"interventionNames":17},"Potassium Nitrate gel","Intervention group (2)",[18],"Drug: Potassium Nitrate Gel",{"label":20,"type":21,"description":22,"interventionNames":23},"5% fluoride varnish","ACTIVE_COMPARATOR","Control group",[24],"Drug: Varnishes, Fluoride",[26,33,39],{"type":27,"name":28,"description":29,"armGroupLabels":30,"otherNames":31},"DRUG","nano hydroxy apatite varnish","Intervention (1)",[9],[32],"Fygg's professional strength, Fygg, USA",{"type":27,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"Potassium Nitrate Gel","Intervention (2)",[15],[38],"Ultradent UltraEZ Desensitizing Gel, Ultradent Inc., USA",{"type":27,"name":40,"description":41,"armGroupLabels":42,"otherNames":43},"Varnishes, Fluoride","Control",[20],[44],"DentKist Charm Varnish 5% Sodium Fluoride Varnish",null,[47],{"name":48,"role":49,"phone":50,"phoneExt":45,"email":51},"Mennat Allah AA Abd Elsabour, PhD student","CONTACT","+201026022605","mennatallah.ashraf@dentistry.cu.edu.eg",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":45,"oldOrganization":45},"PRINCIPAL_INVESTIGATOR","Mennat Allah Ashraf Abd Elsabour Abd Elkareem","Assistant Lecturer, Pediatric Dentistry Department, Ahram Canadian University. PhD student, Pediatric Dentistry and Dental Public Health Department, Cairo University.","100584992","effect-of-nano-hydroxy-apatite-varnish-and-potassium-nitrate-gel-on-the-mih-affected-permanent-teeth-100584992",false,"NCT06896565","Effect of Nano Hydroxy Apatite Varnish and Potassium Nitrate Gel on the MIH-affected Permanent Teeth","Comparative Evaluation of Three Different Topically Applied Materials as Non-invasive Treatment of Permanent Teeth With Molar Incisor Hypo-mineralization: Randomized Clinical Trial","The research unit of this study will be the MIH-affected permanent tooth, in children aged from six to ten years, from either gender.\n\nInclusion criteria:\n\nParticipants related criteria:\n\n1. Children aged from six to ten years old.\n2. Medically free children according to the history taken from their parents.\n3. Children who are categorized as Class I or II according to the American Society of Anaesthesiologists (ASA).\n4. Children whom their parents accept to comply with the follow-up visits.\n5. Children who accept, and their guardians, to participate in the study by signing the informed consent.\n6. Children with no more than four cavitated primary teeth.\n\nTooth related criteria:\n\n1\\. The diagnosis of MIH will be done as per the Wurzburg concept, 2023 MIH diagnostic criteria:\n\nThe child will be confirmed to have MIH if any of the following characteristics are apparent:\n\n* affected teeth show a clearly defined opacity at the occlusal and buccal surfaces of a tooth,\n* defects vary in shape, size, and pattern,\n* white, cream-colored, or yellow-brown color deviations are recognizable,\n* defects variably vary in size,\n* teeth with hypersensitivity are present,\n* teeth have an atypical restoration,\n* permanent teeth for (suspected) MIH reasons are missing (extractions),\n* combinations of the above characteristics are present.\n\n  1. MIH-affected permanent teeth, suffering from dentin hypersensitivity, (MIH-TNI 3, 4a).\n  2. Positive Schiff Cold Airblasting Sensitivity score (score 1, 2, or 3).\n\n     * Exclusion criteria:\n\nParticipants related criteria:\n\n1. Children with severe behavioral or emotional disabilities.\n2. Children who received analgesics within the last 24 hours before the procedure.15\n3. Patients who are using chlorhexidine-based gels or mouthwashes.\n\nTooth related criteria:\n\n1. A tooth with signs and symptoms of irreversible pulpitis.\n2. A tooth with signs and symptoms of necrotic pulp.\n3. Sealing therapy or application of desensitizing agent on the MIH teeth within one month before participation in the study.\n4. Presence of dental caries on the MIH-affected permanent tooth.\n5. Presence of restoration(s) on MIH-affected permanent tooth.","ALL","6 Years","10 Years",{"count":67,"type":68},48,"ESTIMATED","INTERVENTIONAL",[71],"NA","This clinical study main goal is to investigate the effectiveness of nano hydroxy apatite crystal varnish and potassium nitrate gel as a non invasive approach in managing MIH-affected teeth.",[74],"Molar Incisor Hypomineralisation","NOT_YET_RECRUITING","2025-04-22",{"date":78,"type":79},"2025-04-24","ACTUAL",{"date":81,"type":68},"2025-06-01",{"date":83,"type":68},"2026-08-01",{"name":5,"class":6}]