[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100602454":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":18,"locations":18,"responsibleParty":25,"collaborators":18,"id":29,"slug":30,"hasResults":31,"nctId":32,"briefTitle":33,"officialTitle":34,"acronym":18,"eligibilityCriteria":35,"healthyVolunteers":36,"sex":37,"minAge":38,"maxAge":39,"enrollmentInfo":40,"targetDuration":18,"studyType":43,"phases":44,"briefSummary":46,"conditions":47,"keywords":49,"overallStatus":54,"whyStopped":18,"lastUpdateSubmitDate":55,"lastUpdatePostDateStruct":56,"startDateStruct":59,"completionDateStruct":61,"leadSponsor":63,"locationsCount":18},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Nebulized magnesium sulfate group","EXPERIMENTAL","Patients will receive nebulized magnesium sulfate in 5 ml (250 mg) over 15 min.",[13],"Procedure: Nebulization of magnesium sulfate",{"label":15,"type":16,"description":17,"interventionNames":18},"control group","NO_INTERVENTION","Patients will receive nebulized normal saline 5ml, 15 minutes preoperatively",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","Nebulization of magnesium sulfate","patient will be nebulized with 5 mg magnesium sulfate (5 ml) 15 minutes before induction of anesthesia",[9],{"type":26,"investigatorFullName":27,"investigatorTitle":28,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Ayman Abd El-Khalek Mohammed Glala","Lecturer","100602454","effect-of-nebulized-magnesium-sulfate-on-post-intubation-stress-response-in-patients-undergoing-laparoscopic-cholecystectomy-100602454",false,"NCT07123714","Effect of Nebulized Magnesium Sulfate on Post-intubation Stress Response in Patients Undergoing Laparoscopic Cholecystectomy","Effect of Preoperative Nebulized Magnesium Sulfate on Post-intubation Stress Response in Patients Undergoing Laparoscopic Cholecystectomy","Inclusion Criteria:\n\n* American society of anesthesiologists (ASA) physical status I-II.\n* Elective fit laparoscopic cholecystectomy\n\nExclusion Criteria:\n\n* • Patient refusal.\n\n  * Patients with history of hypersensitivity to magnesium sulphate.\n  * Patients with coronary ischemic disease, atrioventricular block of any degree, known cardiac arrhythmias, heart failure on beta blockers or calcium channel blockers expected difficult intubation (Mallampati 4).\n  * Body mass index (BMI) \\> 40 kg\u002Fm2.",true,"ALL","18 Years","70 Years",{"count":41,"type":42},140,"ESTIMATED","INTERVENTIONAL",[45],"NA","This randomized controlled double blinded study will be carried out on 140 patients underwent elective fit laparoscopic cholecystectomy at El-Rajhi Assiut University Hospital.\n\nInclusion criteria:\n\n* 20-50 years old.\n* Both sexes.\n* American society of anesthesiologists (ASA) physical status I-II.\n* Elective fit laparoscopic cholecystectomy\n\nExclusion criteria:\n\n* Patient refusal.\n* Patients with history of hypersensitivity to magnesium sulfate.\n* Patients with coronary ischemic disease, atrioventricular block of any degree, known cardiac arrhythmias, heart failure on beta blockers or calcium channel blockers expected difficult intubation (Mallampati 4).\n* Body mass index (BMI) \\> 40 kg\u002Fm2.\n\nAn online randomization program (http:\u002F\u002Fwww.randomizer.org) will be used to generate a random list and each patients' code will be kept in an opaque sealed envelope. Patients will be randomly allocated with 1:1 allocation ratio into two equal groups in a parallel manner:\n\n* Group A: (N=70) Patients will receive nebulized magnesium sulfate in 5 ml (250 mg) over 15 min.\n* Group B: (N=70) Patients received nebulized normal saline in 5 ml over 15 min, ending 5 min before the induction of anesthesia.\n\nA. Preoperative assessment:\n\nAll patients will be subjected to the followings:\n\n1. Demographic data collection (age, weight, height, BMI, and ASA).\n2. Complete clinical examination.\n3. Routine Laboratory investigations:\n\n   * Random blood sugar.\n   * Blood sample withdrawal for cortisol level at baseline 2ml intravenously. The sample will be sent to be centrifugated within 30 minutes and the serum will be separated and stored in -20°C till time of cortisol level by ELIZA technique.",[48],"Sore Throat",[50,51,52,53],"Magnesium sulfate nebulization","postoperative sore throat","Post-intubation sore throat","Post-intubation stress response","NOT_YET_RECRUITING","2025-08-08",{"date":57,"type":58},"2025-08-14","ACTUAL",{"date":60,"type":42},"2025-08-20",{"date":62,"type":42},"2025-11-10",{"name":5,"class":6}]