[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100608535":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":34,"centralContacts":38,"locations":49,"responsibleParty":78,"collaborators":43,"id":81,"slug":82,"hasResults":83,"nctId":84,"briefTitle":85,"officialTitle":86,"acronym":87,"eligibilityCriteria":88,"healthyVolunteers":83,"sex":89,"minAge":90,"maxAge":43,"enrollmentInfo":91,"targetDuration":43,"studyType":94,"phases":95,"briefSummary":97,"conditions":98,"keywords":43,"overallStatus":69,"whyStopped":43,"lastUpdateSubmitDate":100,"lastUpdatePostDateStruct":101,"startDateStruct":104,"completionDateStruct":106,"leadSponsor":108,"locationsCount":109},{"fullName":5,"class":6},"Assiut University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Neoadjuvant Chemotherapy Arm","ACTIVE_COMPARATOR","Participants in this arm will receive standard-of-care neoadjuvant chemotherapy (NAC) before undergoing radical cystectomy for muscle-invasive bladder cancer (MIBC). MRI will be performed post-NAC for local tumor restaging, and the results will be compared to histopathology to evaluate the diagnostic accuracy of MRI.",[13,14],"Drug: Neoadjuvant Chemotherapy","Procedure: Radical Cystectomy",{"label":16,"type":10,"description":17,"interventionNames":18},"Radical cystectomy-Only arm","Participants in this arm will undergo immediate radical cystectomy without receiving neoadjuvant chemotherapy. MRI will be performed preoperatively for local tumor staging, and results will be compared with post-surgical histopathology to assess the accuracy of MRI in this setting.",[14],[20,27],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Neoadjuvant Chemotherapy","Standard neoadjuvant chemotherapy for muscle-invasive bladder cancer, typically consisting of cisplatin-based regimens such as MVAC (methotrexate, vinblastine, doxorubicin, and cisplatin) or gemcitabine and cisplatin. Administered prior to radical cystectomy to shrink the tumor and improve surgical outcomes. The post-treatment MRI findings will be analyzed for correlation with histopathological results after surgery.",[9],[26],"NAC",{"type":28,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"PROCEDURE","Radical Cystectomy","Surgical removal of the urinary bladder, typically performed in patients with muscle-invasive bladder cancer. In this study, participants in both arms will undergo radical cystectomy, either directly or following neoadjuvant chemotherapy. Histopathological examination of surgical specimens will be compared with MRI findings for staging accuracy assessment.",[9,16],[33],"RC",[35],{"name":36,"affiliation":5,"role":37},"Amr Darwish, Lecturer","PRINCIPAL_INVESTIGATOR",[39,45],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},"Hamza Elhashamy, MBBCh","CONTACT","+201028635437",null,"Hamza.Ahmed00099@med.aun.edu.eg",{"name":46,"role":41,"phone":47,"phoneExt":43,"email":48},"Abdelrahman Abdelshafi, MBBCh","+201123740500","abdulrahman.18313572@med.aun.edu.eg",[50,68],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Urology Department, Faculty of Medicine, Assiut University","NOT_YET_RECRUITING","Asyut","Asyut Governorate","71515","Egypt","EG",{"type":59,"coordinates":60},"Point",[61,62],31.18368,27.18096,{"lat":62,"lon":61},[65,66,67],{"name":40,"role":41,"phone":42,"phoneExt":43,"email":44},{"name":46,"role":41,"phone":47,"phoneExt":43,"email":48},{"name":36,"role":37,"phone":43,"phoneExt":43,"email":43},{"facility":51,"status":69,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":70,"geoPoint":72,"contacts":73},"RECRUITING",{"type":59,"coordinates":71},[61,62],{"lat":62,"lon":61},[74],{"name":75,"role":41,"phone":76,"phoneExt":43,"email":77},"Amr Esam Darwish, MD","01015817851","amrdarwish@aun.edu.eg",{"type":37,"investigatorFullName":79,"investigatorTitle":80,"investigatorAffiliation":5,"oldNameTitle":43,"oldOrganization":43},"Amr Esam Saad Mohamed Darwish","Lecturer","100608535","effect-of-neoadjuvant-chemotherapy-on-mri-accuracy-before-cystectomy-100608535",false,"NCT07202819","Effect of Neoadjuvant Chemotherapy on MRI Accuracy Before Cystectomy","Does Neoadjuvant Chemotherapy Affect the Accuracy of Magnetic Resonance Imaging Before Radical Cystectomy? A Randomized Controlled Trial.","\"NAC-MRI\"","Inclusion Criteria:\n\n* Patients diagnosed with cT2 urothelial carcinoma of the urinary bladder, according to the TNM classification, who give informed, written consent on participation in the study and approve all its requirements.\n\nExclusion Criteria:\n\n* Patients who have received pelvic radiotherapy.\n* Previous open or laparoscopic pelvic surgery.\n* Patients with contraindications to MRI.\n* Patients who are unfit for or refuse radical cystectomy.\n* Ineligibility to cisplatin.\n* squamous differentiation in the histopathology","ALL","18 Years",{"count":92,"type":93},76,"ESTIMATED","INTERVENTIONAL",[96],"NA","The goal of this clinical trial is to learn if neoadjuvant chemotherapy (NAC) affects the accuracy of magnetic resonance imaging (MRI) in staging muscle-invasive bladder cancer (MIBC). This study will also assess how tissue changes induced by NAC impact MRI interpretation. The main questions it aims to answer are:\n\nDoes NAC compromise the accuracy of MRI in staging MIBC?\n\nDoes NAC-induced tissue change affect the reliability of MRI in tumor assessment?\n\nResearchers will compare MRI staging accuracy in MIBC patients who received NAC to those who went directly to surgery, to see if NAC impacts MRI's diagnostic performance.\n\nParticipants will:\n\nUndergo MRI scanning before surgery\n\nReceive either NAC or go directly to surgery, depending on their group assignment\n\nHave their MRI results compared to histopathological outcomes after surgery",[99],"Muscle Invasive Bladder Cancer","2025-09-24",{"date":102,"type":103},"2025-10-02","ACTUAL",{"date":105,"type":103},"2025-09-01",{"date":107,"type":93},"2026-08-20",{"name":5,"class":6},2]