[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637487":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":23,"centralContacts":28,"locations":37,"responsibleParty":55,"collaborators":19,"id":58,"slug":59,"hasResults":60,"nctId":61,"briefTitle":62,"officialTitle":63,"acronym":19,"eligibilityCriteria":64,"healthyVolunteers":60,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":19,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":77,"overallStatus":82,"whyStopped":19,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Izmir Katip Celebi University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Neuromuscular electrical stimulation (NMES)","EXPERIMENTAL","Neuromuscular electrical stimulation (NMES) (a symmetric, biphasic, rectangular waveform) will be administered to the antagonist wrist extensors (extensor carpi radialis longus\u002Fbrevis and extensor carpi ulnaris) of the spastic wrist flexors in the B (intervention) phase. The configuration consists of an application duration of 20 minutes, a stimulation frequency of 35 Hz, and a pulse duration of 300 μs. The duty cycle will feature a 20-second ON time and 20-second OFF time (1:1 ratio), with ramp-up and ramp-down durations set at 5 seconds. During Phase A, no intervention will be carried out",[13],"Device: Neuromuscular electrical stimulation (NMES)",[15,20],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","Neuromuscular electrical stimulation (NMES) (a symmetric, biphasic, rectangular waveform) will be administered to the antagonist wrist extensors (extensor carpi radialis longus\u002Fbrevis and extensor carpi ulnaris) of the spastic wrist flexors in the B phase. The configuration consists of an application duration of 20 minutes, a stimulation frequency of 35 Hz, and a pulse duration of 300 μs. The duty cycle will feature a 20-second ON time and 20-second OFF time (1:1 ratio), with ramp-up and ramp-down durations set at 5 seconds.",[9],null,{"type":16,"name":9,"description":21,"armGroupLabels":22,"otherNames":19},"Neuromuscular electrical stimulation (NMES) is a therapeutic modality used in neurorehabilitation. By delivering transcutaneous electrical currents, NMES elicits repetitive, patterned muscle contractions to augment or restore motor functions.",[9],[24],{"name":25,"affiliation":26,"role":27},"İlker Şengül, M.D.","İzmir Katip Çelebi University","PRINCIPAL_INVESTIGATOR",[29,33],{"name":25,"role":30,"phone":31,"phoneExt":19,"email":32},"CONTACT","+905337333698","ilkrsngl@gmail.com",{"name":34,"role":30,"phone":35,"phoneExt":19,"email":36},"Aleyna Uğurlu, M.D.","+905433466277","aleynaugurlu2000@gmail.com",[38],{"facility":26,"status":19,"city":39,"state":40,"zip":41,"country":42,"countryCode":19,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Izmir","Karabağlar","35150","Turkey (Türkiye)",{"type":44,"coordinates":45},"Point",[46,47],27.13838,38.41273,{"lat":47,"lon":46},[50,51,52,53],{"name":25,"role":30,"phone":31,"phoneExt":19,"email":32},{"name":34,"role":30,"phone":35,"phoneExt":19,"email":36},{"name":25,"role":27,"phone":19,"phoneExt":19,"email":19},{"name":34,"role":54,"phone":19,"phoneExt":19,"email":19},"SUB_INVESTIGATOR",{"type":27,"investigatorFullName":56,"investigatorTitle":57,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"ilker şengül","Principal Investigator","100637487","effect-of-nmes-on-spasticity-100637487",false,"NCT07617311","Effect of NMES on Spasticity","The Effect of Neuromuscular Electrical Stimulation on Spasticity: A Single-Subject Experimental Study","Inclusion Criteria:\n\n* Age between 18 and 70 years\n* Post-stroke wrist flexor spasticity scored as Grade 2 or 3 on the Australian Spasticity Assessment Scale (ASAS), specifically selecting patients whose passive stretch resistance (post-catch response) can be easily overcome to ensure accurate and unconfounded electrophysiological evaluation.\n* Provision of voluntary, written informed consent prior to study enrollment.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>70 year\n* Contraindications to neuromuscular electrical stimulation (e.g., active electronic implants, history of epilepsy, or localized skin lesions preventing electrode placement)\n* Concomitant wrist contracture or pain sufficient to impede clinical evaluation\n* Structural abnormalities of the elbow joint obstructing median nerve stimulation\n* Median nerve neuropathy or injury in the ipsilateral upper extremity.\n* Non-stable dosage of antispastic medications within the 2 weeks prior to baseline\n* Initiation of medications affecting nerve conduction (e.g., antidepressants, anticonvulsants, anesthetics) within the past month; patients on a stable dose for \\>1 month remain eligible\n* Botulinum toxin infiltration in the target spastic muscles within the preceding 3 months\n* History of neurolytic procedures targeting spasticity in the affected limb.\n* History of orthopedic or neurological surgery targeting spasticity in the affected limb\n* Cognitive impairment severe enough to compromise adherence to study protocols\n* Inability to maintain the required testing positions for the upper extremity joints (shoulder, elbow, forearm, and wrist)\n* Pregnancy","ALL","18 Years","70 Years",{"count":69,"type":70},4,"ESTIMATED","INTERVENTIONAL",[73],"NA","The goal of this clinical trial is to learn if neuromuscular electrical stimulation (NMES) works to treat spasticity in adult patients with spasticity related to stroke. The main question it aims to answer is:\n\n• Does NMES reduces the severity of spasticity? Researchers will compare NMES treatment to baseline and non-stimulation periods to see if NMES works to treat spasticity.\n\nParticipants will:\n\n• first undergo an initial assessment at 10-minute intervals for one hour, followed by 20 minutes of NMES exposure, and subsequent post-treatment assessments at 10-minute intervals for two hours. This daily procedure will be repeated over four days for one patient, and performed only once for the remaining three patients.",[76],"Post-Stroke Spasticity",[78,79,80,81],"Post-stroke spasticity","Neuromuscular electrical stimulation","Muscle reaction angle","H reflex","NOT_YET_RECRUITING","2026-05-31",{"date":85,"type":86},"2026-06-03","ACTUAL",{"date":88,"type":70},"2026-06-15",{"date":90,"type":70},"2028-03-16",{"name":5,"class":6},1]