[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635016":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":25,"centralContacts":33,"locations":41,"responsibleParty":64,"collaborators":24,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":73,"eligibilityCriteria":74,"healthyVolunteers":69,"sex":75,"minAge":76,"maxAge":24,"enrollmentInfo":77,"targetDuration":24,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":87,"overallStatus":44,"whyStopped":24,"lastUpdateSubmitDate":96,"lastUpdatePostDateStruct":97,"startDateStruct":100,"completionDateStruct":102,"leadSponsor":104,"locationsCount":105},{"fullName":5,"class":6},"Al-Mustansiriyah University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Smokers","ACTIVE_COMPARATOR","22 adult patients with Stage II or III periodontitis who currently smoke. They will receive standardized non-surgical periodontal therapy.",[13],"Procedure: Non-surgical periodontal therapy (Scaling and root planing)",{"label":15,"type":10,"description":16,"interventionNames":17},"Non-smokers","22 adult patients with Stage II or III periodontitis who have never smoked or quit more than 5 years ago. They will receive standardized non-surgical periodontal therapy.",[13],[19],{"type":20,"name":21,"description":22,"armGroupLabels":23,"otherNames":24},"PROCEDURE","Non-surgical periodontal therapy (Scaling and root planing)","Standardized non-surgical periodontal therapy performed over two visits (scaling at the first visit and root planing after one week).",[15,9],null,[26,30],{"name":27,"affiliation":28,"role":29},"Hussein Abdul-Rassul Hatiem, B.D.S., M.Sc. Student","College of Dentistry \u002F Mustansiriyah University","PRINCIPAL_INVESTIGATOR",{"name":31,"affiliation":28,"role":32},"Ghasaq Asim Abdulwahab, B.D.S., M.Sc., Ph.D.","STUDY_DIRECTOR",[34,38],{"name":27,"role":35,"phone":36,"phoneExt":24,"email":37},"CONTACT","+9647703916382","husseinabdulrassol@uomustansiriyah.edu.iq",{"name":31,"role":35,"phone":39,"phoneExt":24,"email":40},"+9647901174767","ghasaq.a.abdulwahhab@uomustansiriyah.edu.iq",[42,56],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":24},"Al-Sadr Specialized Dental Center","RECRUITING","Baghdad","Baghdad Governorate","10001","Iraq","IQ",{"type":51,"coordinates":52},"Point",[53,54],44.40088,33.34058,{"lat":54,"lon":53},{"facility":57,"status":44,"city":45,"state":46,"zip":24,"country":48,"countryCode":49,"cosmosGeoPoint":58,"geoPoint":60,"contacts":61},"Sadr Specialized Dental Center",{"type":51,"coordinates":59},[53,54],{"lat":54,"lon":53},[62,63],{"name":27,"role":35,"phone":36,"phoneExt":24,"email":37},{"name":31,"role":35,"phone":39,"phoneExt":24,"email":40},{"type":29,"investigatorFullName":65,"investigatorTitle":66,"investigatorAffiliation":5,"oldNameTitle":24,"oldOrganization":24},"Hussein Abdul-Rassul Hateim","Principal Investigator","100635016","effect-of-non-surgical-periodontal-therapy-on-salivary-biomarkers-in-smokers-and-non-smokers-with-periodontitis-100635016",false,"NCT07547202","Effect of Non-Surgical Periodontal Therapy on Salivary Biomarkers in Smokers and Non-Smokers With Periodontitis","The Significance of Non-Surgical Periodontal Therapy on Salivary Dkk-1, Sclerostin, and PLAP-1 Levels in Smoker and Non-Smoker Patients With Periodontitis: A Clinical Comparative Study","NSPT-Biomarker","Inclusion Criteria:\n\n* Systemically healthy.\n* Diagnosed with Stage II and III periodontitis.\n* Presence of ≥ 20 teeth (excluding third molars).\n* Current smoker OR non-smoker\n\nExclusion Criteria:\n\n* Presence of systemic diseases affecting the periodontium.\n* Use of medications affecting inflammation.\n* Received periodontal therapy in the past 6 months.\n* Received antibiotic therapy in the last 3 months.\n* Alcohol use.","ALL","18 Years",{"count":78,"type":79},44,"ESTIMATED","INTERVENTIONAL",[82],"NA","This study evaluates the effect of non-surgical periodontal therapy on salivary biomarkers (Dkk-1, Sclerostin, and PLAP-1) and clinical periodontal parameters in patients with periodontitis. Periodontitis is a chronic inflammatory disease that destroys tooth-supporting tissues. Smoking is a significant risk factor that worsens periodontal destruction and reduces the effectiveness of standard therapies.\n\n* The trial is a non-randomized comparative clinical study.\n* It includes 44 adult patients diagnosed with Stage II and III periodontitis.\n* The participants are divided into two equal groups: 22 current smokers and 22 non-smokers.\n* Participants will undergo a baseline examination, followed by standardized non-surgical periodontal therapy consisting of scaling and root planing.\n* A follow-up visit will be conducted six weeks post-therapy to repeat clinical measurements and saliva collection.\n* The primary objective is to evaluate changes in salivary biomarker levels and clinical parameters (Plaque Index, Gingival Index, bleeding on probing, Probing Pocket Depth, Clinical Attachment Level) after treatment.",[85,86],"Periodontitis","Smoking ( Cigarette)",[85,88,89,90,91,92,93,94,95],"Smoking","Non-surgical periodontal therapy","Scaling and root planing","Salivary biomarkers","Dkk-1","Sclerostin","PLAP-1","SOST","2026-04-20",{"date":98,"type":99},"2026-04-23","ACTUAL",{"date":101,"type":99},"2026-01-01",{"date":103,"type":79},"2026-10-01",{"name":5,"class":6},2]