[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616538":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":11,"centralContacts":26,"locations":11,"responsibleParty":37,"collaborators":11,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":46,"acronym":47,"eligibilityCriteria":48,"healthyVolunteers":49,"sex":50,"minAge":51,"maxAge":52,"enrollmentInfo":53,"targetDuration":11,"studyType":56,"phases":57,"briefSummary":59,"conditions":60,"keywords":63,"overallStatus":65,"whyStopped":11,"lastUpdateSubmitDate":66,"lastUpdatePostDateStruct":67,"startDateStruct":70,"completionDateStruct":72,"leadSponsor":74,"locationsCount":11},{"fullName":5,"class":6},"Assiut University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"OpioidSparingGroup OS)","ACTIVE_COMPARATOR",null,[13],"Other: opoid free anesthesia",{"label":15,"type":10,"description":11,"interventionNames":16},"ControlGroup (CG)",[13],[18],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"opoid free anesthesia","Maintenance Dexmedetomidine 0.2-0.5 µg\u002Fkg\u002Fh + Lidocaine 1.5 mg\u002Fkg\u002Fh + Magnesium 10 mg\u002Fkg\u002Fh; Sevoflurane as required; Atracurium 0.1 mg\u002Fkg IV PRN",[15,9],[23,24,25],"Lidocaine","Dexmedetomidine","Magnesium",[27,33],{"name":28,"role":29,"phone":30,"phoneExt":31,"email":32},"Ola Mahmoud Wahba Gnedy, Assistant Prof.","CONTACT","01151121981","+2","ola.genadi@med.aun.edu.eg",{"name":34,"role":29,"phone":35,"phoneExt":31,"email":36},"Mohamed Bakr Eid, prof","01223213370","bakr@aun.edu.eg",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":11,"oldOrganization":11},"PRINCIPAL_INVESTIGATOR","Galal Eldeen Hasan Hasan Hussein","resident at the anesthesia , icu and pain management department","100616538","effect-of-opioid-free-anesthesia-ofa-on-postoperative-pain-and-perioperative-nausea-and-vomiting-in-elective-laparoscopic--100616538",false,"NCT07306910","Effect of Opioid-Free Anesthesia (OFA) on Postoperative Pain and Perioperative Nausea and Vomiting in Elective Laparoscopic .","Effect of Opioid-Free Anesthesia (OFA) on Postoperative Pain and Perioperative Nausea and Vomiting in Elective Laparoscopic Cholecystectomy.","OFA","Inclusion Criteria:\n\n* Adults aged 18 to 60 years scheduled for elective laparoscopic cholecystectomy. Elective must be included in title.\n* ASA (American Society of Anesthesiologists) physical status I or II.\n* Body Mass Index (BMI) \\\u003C 35 kg\u002Fm².\n\nExclusion Criteria:\n\n* Chronic opioid use (\\>30 MME\u002Fday for \\>3 months).\n* Contraindications to study medications (e.g., severe hepatic impairment; allergy\u002Fcontraindication to lidocaine, dexmedetomidine, ketamine, fentanyl, or NSAIDs).\n* Renal dysfunction (eGFR \\\u003C60 mL\u002Fmin\u002F1.73 m²).\n* Significant cardiac conduction abnormalities.\n* Pregnancy or lactation.\n* Emergency surgery or conversion to open cholecystectomy",true,"ALL","18 Years","60 Years",{"count":54,"type":55},110,"ESTIMATED","INTERVENTIONAL",[58],"NA","1. To evaluate the efficacy of a standardized multimodal Opioid Sparing (OS) protocol versus conventional opioid-based analgesia in reducing acute postoperative\n2. To quantify opioid consumption reduction achievable through OS strategies\n3. To assess the impact of OS on hemodynamic parameters during critical surgical phases\n4. To compare recovery metrics (PONV, bowel function, ambulation)\n5. To evaluate the safety profile of OS anesthesia",[61,62],"Opioid-Free Anesthesia","Elective Laparoscopic Cholecystectomy",[64],"opa","NOT_YET_RECRUITING","2025-12-13",{"date":68,"type":69},"2025-12-29","ACTUAL",{"date":71,"type":55},"2025-12-30",{"date":73,"type":55},"2028-12-30",{"name":5,"class":6}]