[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634642":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":35,"locations":25,"responsibleParty":41,"collaborators":25,"id":44,"slug":45,"hasResults":46,"nctId":47,"briefTitle":48,"officialTitle":49,"acronym":25,"eligibilityCriteria":50,"healthyVolunteers":46,"sex":51,"minAge":52,"maxAge":53,"enrollmentInfo":54,"targetDuration":25,"studyType":57,"phases":58,"briefSummary":60,"conditions":61,"keywords":63,"overallStatus":67,"whyStopped":25,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":25},{"fullName":5,"class":6},"Escola Superior de Tecnologia da Saúde do Porto","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Control group","PLACEBO_COMPARATOR","In the control group, bilateral contact of the acromioclavicular joint was performed.",[13],"Other: Placebo technique",{"label":15,"type":16,"description":17,"interventionNames":18},"Experimental group","EXPERIMENTAL","The intervention consisted of two phases: a structural technique involving a high-velocity, low-amplitude thrust on segment C2 (Tixa \\& Ebenegger, 2016), followed by a functional suboccipital inhibition technique (Chamtepie \\& Pérot, 2008).",[19],"Other: Osteopathic Intervention Protocol",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Osteopathic Intervention Protocol","Starting by locating the C2 segment with the metacarpophalangeal joint of the second finger, whilst the other hand rested on the participant's face, homolateral inclination and contralateral rotation were induced, applying a thrust directed into rotation. In this phase, two attempts were made on each side, starting with the right side.\n\nIn the second phase, the suboccipital inhibition technique was performed in the occipital region, using contact with the thenar and hypothenar eminences, positioning the distal metacarpophalangeal joints at the level of the superior nuchal line, over the suboccipital musculature, promoting gentle pressure towards the ceiling, associated with cephalic traction, lasting for three minutes.",[15],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Placebo technique","The researcher was positioned at the head of the table, making bilateral contact with the acromioclavicular joint and maintaining this position for 3 minutes, assisted by a stopwatch.",[9],[31],{"name":32,"affiliation":33,"role":34},"Natália MO Campelo","ESS","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":25,"email":40},"Natália MO Campelo, PhD","CONTACT","+351 222 061 000","nmc@ess.ipp.pt",{"type":34,"investigatorFullName":42,"investigatorTitle":43,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Natália Maria Oliveira Campelo","Doctor teacher","100634642","effect-of-osteopathic-intervention-on-migraine-100634642",false,"NCT07542340","Effect of Osteopathic Intervention on Migraine","Effect of Osteopathic Intervention on Migraine: A Randomised Controlled Trial","Inclusion Criteria:\n\n* Age between 18 and 50 years.\n* Presented five or more migraine episodes according to the criteria established by Monteiro et al. (2009), namely headache episodes with a minimum duration of 4 hours, unilateral location, pulsating character, photophobia, phonophobia, nausea, and vomiting.\n\nExclusion Criteria:\n\n* recent traumas not investigated by complementary examinations, clinical history of cranio-cervical traumas, such as fracture, dislocation, and ligament rupture (Ricard \\& Sallé, 2010; Croibier, 2005);\n* tumours, meningitis, neuropraxia, disc herniation, or cervical hemivertebra (Ricard \\& Sallé, 2010; Croibier, 2005);\n* contagious disease, such as tuberculosis (Croibier, 2005);\n* cardiovascular diseases, such as severe arterial hypertension, venous thrombosis, myocardial infarction, angina pectoris, recent stroke, intracranial arterial aneurysm (Croibier, 2005);\n* advanced osteoporosis (Croibier, 2005);\n* radiotherapy\u002Fchemotherapy treatment currently active or within 6 months of the last session (Croibier, 2005);\n* anticoagulant medication, vitamin K, treatment with corticosteroids, analgesics, and NSAIDs 10 to 15 days per month (Bigal et al., 2008; Croibier, 2005; International Headache Society (IHS), 2018).","ALL","18 Years","50 Years",{"count":55,"type":56},45,"ESTIMATED","INTERVENTIONAL",[59],"NA","Migraine is a common, disabling neurological condition characterized by severe, often unilateral pain accompanied by sensory symptoms like nausea and photophobia. Its pathophysiology involves activation of the trigeminovascular system, neuro-inflammation, and nervous system sensitisation.\n\nDue to the convergence of trigeminal and cervical nerves in the upper neck (C2), manual therapy may influence migraine symptoms. Osteopathic techniques, such as suboccipital inhibition and C2 manipulation, aim to reduce pain intensity and frequency by normalising mobility and reducing nociceptive stimulation. While promising, further research is needed to validate these interventions through rigorous clinical trials.",[62],"Migraine",[64,62,65,66],"Suboccipital Inhibition","Osteopathic Manipulative Treatment","Osteopathy","NOT_YET_RECRUITING","2026-04-28",{"date":70,"type":71},"2026-05-04","ACTUAL",{"date":73,"type":56},"2026-06",{"date":75,"type":56},"2026-09",{"name":5,"class":6}]