[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100634453":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":29,"responsibleParty":46,"collaborators":49,"id":53,"slug":54,"hasResults":55,"nctId":56,"briefTitle":57,"officialTitle":58,"acronym":10,"eligibilityCriteria":59,"healthyVolunteers":55,"sex":60,"minAge":61,"maxAge":10,"enrollmentInfo":62,"targetDuration":10,"studyType":65,"phases":10,"briefSummary":66,"conditions":67,"keywords":71,"overallStatus":31,"whyStopped":10,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Seoul National University Bundang Hospital","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"oXiris Group",null,"Patients with septic shock and acute kidney injury (AKI) who initiated continuous renal replacement therapy (CRRT) using the oXiris® hemofilter at Time zero. Data for this cohort are collected from five tertiary medical centers in South Korea. The oXiris® filter is used for its combined functions of cytokine adsorption, endotoxin removal, and standard CRRT.",{"label":13,"type":10,"description":14,"interventionNames":10},"Control Group (Standard CRRT)","Patients with septic shock and AKI who initiated CRRT using a standard (non-adsorptive) hemofilter at Time zero. This cohort is identified and extracted from the Korea Sepsis Alliance (KSA) registry, a multicenter prospective sepsis cohort in South Korea. These patients receive standard-of-care CRRT without specific hemoadsorption properties.",[16],{"name":17,"affiliation":5,"role":18},"Sung Yoon Lim, MD.PhD","PRINCIPAL_INVESTIGATOR",[20,25],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"Sung Yoon Lim, MD. PhD","CONTACT","82+1028469179","nucleon727@snu.ac.kr",{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},"Myung Jin Song, MD.PhD","82+1045990531","mjsong8705@gmail.com",[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":10,"cosmosGeoPoint":36,"geoPoint":41,"contacts":42},"RECRUITING","Seongnam-si","Gyeonggi-do","13620","South Korea",{"type":37,"coordinates":38},"Point",[39,40],127.13778,37.43861,{"lat":40,"lon":39},[43,45],{"name":44,"role":22,"phone":23,"phoneExt":10,"email":24},"Sung Yoon Lim, MD PhD",{"name":26,"role":22,"phone":27,"phoneExt":10,"email":28},{"type":18,"investigatorFullName":47,"investigatorTitle":48,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"LIM SUNG YOON","Associate professor",[50],{"name":51,"class":52},"Vantive Health LLC","INDUSTRY","100634453","effect-of-oxiris-hemofilter-use-in-septic-shock-a-multicenter-retrospective-cohort-study-100634453",false,"NCT07539883","Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study","Official Title: Effect of oXiris Hemofilter Use in Septic Shock: A Multicenter Retrospective Cohort Study Using a Target Trial Emulation Approach","Inclusion Criteria:\n\n* Adults aged 19 years or older.\n* Admitted to the ICU with septic shock (Sepsis-3 criteria) between March 2021 and August 2025.\n* Required Continuous Renal Replacement Therapy (CRRT) due to acute kidney injury (AKI).\n\nExclusion Criteria:\n\n* Death or withdrawal of life-sustaining therapy within 48 hours of ICU admission.\n* Patients with End-Stage Renal Disease (ESRD).\n* Patients with missing critical covariates.","ALL","19 Years",{"count":63,"type":64},360,"ESTIMATED","OBSERVATIONAL","This study aims to evaluate the clinical effectiveness of the oXiris® hemofilter in patients with septic shock and acute kidney injury (AKI) requiring continuous renal replacement therapy (CRRT). While some studies suggest that oXiris® may improve hemodynamic stability by removing endotoxins and cytokines, its impact on survival remains inconsistent.To provide more reliable causal evidence, this multicenter retrospective cohort study utilizes a Target Trial Emulation (TTE) approach. The study will compare patients treated with the oXiris® filter to those treated with standard CRRT filters, focusing on in-hospital mortality and other clinical outcomes such as fluid balance and vasopressor requirements.",[68,69,70],"Septic Shock","Multiorgan Failure","Sepsis",[72,73,74],"oXiris","Target Trial Emulation","Extracorporeal Blood Purification","2026-04-13",{"date":77,"type":78},"2026-04-20","ACTUAL",{"date":80,"type":78},"2026-01-22",{"date":82,"type":64},"2026-12-31",{"name":5,"class":6},1]