[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100623634":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":27,"centralContacts":32,"locations":18,"responsibleParty":42,"collaborators":18,"id":45,"slug":46,"hasResults":47,"nctId":48,"briefTitle":49,"officialTitle":50,"acronym":18,"eligibilityCriteria":51,"healthyVolunteers":47,"sex":52,"minAge":53,"maxAge":54,"enrollmentInfo":55,"targetDuration":18,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":66,"overallStatus":72,"whyStopped":18,"lastUpdateSubmitDate":73,"lastUpdatePostDateStruct":74,"startDateStruct":77,"completionDateStruct":79,"leadSponsor":81,"locationsCount":18},{"fullName":5,"class":6},"Ondokuz Mayıs University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"IBUPROFEN (GROUP B)","EXPERIMENTAL","In the study, patients will be randomized into two groups (Group B: ibuprofen group; Group C: control group). Patients in Group B will receive 400 mg intravenous ibuprofen administered by the anesthesia research resident 15 minutes before the surgical incision. Group B patients will also receive postoperative intravenous ibuprofen at a dose of 400 mg three times daily. No intraoperative or postoperative ibuprofen treatment will be administered to patients in Group C.",[13],"Drug: ibuprofen",{"label":15,"type":16,"description":17,"interventionNames":18},"CONTROL (GROUP C)","NO_INTERVENTION","In this study, patients will be randomized into two groups (Group B: ibuprofen group; Group C: control group). Patients in Group B will receive 400 mg IV ibuprofen administered by the anesthesia research resident 15 minutes before the surgical incision. Group B patients will also receive postoperative IV ibuprofen at a dose of 400 mg three times daily. No intraoperative or postoperative ibuprofen treatment will be administered to patients in Group C.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","ibuprofen","In the study, patients in Group B will receive a single intraoperative dose of 400 mg IV ibuprofen, followed by postoperative administration of 400 mg IV ibuprofen three times daily for 24 hours. We hypothesize that, by benefiting from the anti-inflammatory effects of ibuprofen, intraoperative cerebral oxygenation will be preserved, thereby reducing the incidence of postoperative delirium and cognitive dysfunction.",[9],[26],"IV ibuprofen",[28],{"name":29,"affiliation":30,"role":31},"Canan ASAR SAHIN","Ondokuz Mayıs University Faculty of Medicine Department of Anesthesiology and Reanimation","STUDY_DIRECTOR",[33,38],{"name":34,"role":35,"phone":36,"phoneExt":18,"email":37},"Elif Bengi SENER","CONTACT","+90 (532) 341 67 11","bengimd@gmail.com",{"name":39,"role":35,"phone":40,"phoneExt":18,"email":41},"Halil CEBECI, Asst. prof.","+(90) 505 387 23 85","halilcebeci55@gmail.com",{"type":43,"investigatorFullName":34,"investigatorTitle":44,"investigatorAffiliation":5,"oldNameTitle":18,"oldOrganization":18},"PRINCIPAL_INVESTIGATOR","Professor of Anesthesiology","100623634","effect-of-perioperative-iv-ibuprofen-on-cerebral-oxygenation-and-postoperative-cognition-during-one-lung-ventilation-100623634",false,"NCT07399184","Effect of Perioperative IV Ibuprofen on Cerebral Oxygenation and Postoperative Cognition During One-Lung Ventilation","Comparison of the Effects of Ibuprofen on Cerebral Oxygenation, Postoperative Cognitive Dysfunction, and Delirium in One-Lung Ventilation","Inclusion Criteria:\n\n* Patients aged 18-75 years\n* American Society of Anesthesiologists (ASA) Physical Status Classification System I-III\n* Patients scheduled for lobectomy or segmentectomy via Video-Assisted Thoracic Surgery (VATS ) with one-lung ventilation\n* New York Heart Association (NYHA) class I-II\n* Patients who have been informed about the study and have provided written informed consent will be included.\n\nExclusion Criteria:\n\n* Patients younger than 18 years or older than 75 years\n* History of alcohol or substance abuse\n* Patients with chronic NSAID use and\u002For NSAID use within the last 30 days, or NSAID allergy\n* Allergy to other drugs used in the study (e.g., bupivacaine)\n* ASA Physical Status IV-V\n* Severe hearing, visual, or speech impairment\n* Dementia, Alzheimer's disease, or psychiatric disorders (psychosis, bipolar disorder, schizophrenia)\n* History of previous head trauma\n* Chronic liver disease\n* Pregnancy\n* History of cerebrovascular disease\n* Moderate-to-severe chronic obstructive pulmonary disease (COPD) (predicted FEV₁ \\\u003C50%)\n* GFR \\\u003C60 mL\u002Fmin\u002F1.73 m²\n* Patients who do not provide written informed consent\n* Conditions that may cause inaccurate cerebral oximetry readings (subdural and\u002For extracranial hematoma, intracranial arteriovenous shunts, hyperbilirubinemia)\n* Patients undergoing emergency surgery\n* Patients in whom surgery is initiated as thoracotomy or converted to thoracotomy\n* Patients unable to complete the preoperative MMSE (total score ≤24) will be excluded.","ALL","18 Years","75 Years",{"count":56,"type":57},54,"ESTIMATED","INTERVENTIONAL",[60],"NA","This study compares the effects of ibuprofen administered during surgery and within the first 24 hours after surgery, versus no ibuprofen, on cerebral oxygenation, postoperative changes in consciousness (postoperative delirium and cognitive dysfunction), length of stay in the intensive care unit, and the incidence of postoperative pain, nausea, vomiting, and pruritus in patients undergoing lung lobectomy or segmentectomy using a closed (video-assisted) method (VATS - video-assisted thoracoscopic surgery), in whom one-lung ventilation is applied.\n\nThe aim of this study is to evaluate the effects of ibuprofen on cerebral oxygenation, postoperative cognitive changes, and delirium in patients undergoing one-lung ventilation.",[63,64,65],"Postoperative Delirium","Cerebral Oxygen Saturation","Postoperative Cognitive Dysfunction (POCD)",[67,68,69,70,71,22],"cerebral oxygenation","near infrared spectroscopy","thoracic anesthesia","postoperative delirium","one lung ventilation","NOT_YET_RECRUITING","2026-02-08",{"date":75,"type":76},"2026-02-10","ACTUAL",{"date":78,"type":57},"2026-02-15",{"date":80,"type":57},"2026-09-01",{"name":5,"class":6}]