[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100642210":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":42,"responsibleParty":57,"collaborators":29,"id":60,"slug":61,"hasResults":62,"nctId":63,"briefTitle":64,"officialTitle":65,"acronym":29,"eligibilityCriteria":66,"healthyVolunteers":67,"sex":68,"minAge":69,"maxAge":70,"enrollmentInfo":71,"targetDuration":29,"studyType":74,"phases":75,"briefSummary":77,"conditions":78,"keywords":80,"overallStatus":45,"whyStopped":29,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":88,"leadSponsor":90,"locationsCount":91},{"fullName":5,"class":6},"Palacky University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Molecular hydrogen","EXPERIMENTAL","Molecular hydrogen inhalation for 60 minutes daily for 7 days.",[13],"Other: Molecular hydrogen",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo","PLACEBO_COMPARATOR","Ambient air inhalation for 60 minutes daily for 7 days.",[19],"Other: Placebo",[21,26],{"type":6,"name":9,"description":22,"armGroupLabels":23,"otherNames":24},"Gas mixture containing 3.75% molecular hydrogen and ambient air.",[9],[25],"H2 Air-Blend Generator (H2 Medical Technologies, Ostrava, Czech Republic)",{"type":6,"name":15,"description":27,"armGroupLabels":28,"otherNames":29},"Ambient air without molecular hydrogen.",[15],null,[31],{"name":32,"affiliation":5,"role":33},"Tereza Rysava","PRINCIPAL_INVESTIGATOR",[35,39],{"name":32,"role":36,"phone":37,"phoneExt":29,"email":38},"CONTACT","+420585636154","tereza.rysava01@upol.cz",{"name":40,"role":36,"phone":29,"phoneExt":29,"email":41},"Jakub Krejci, PhD","jakub.krejci@upol.cz",[43],{"facility":44,"status":45,"city":46,"state":29,"zip":47,"country":48,"countryCode":29,"cosmosGeoPoint":49,"geoPoint":54,"contacts":55},"Palacky University, Faculty of Physical Culture","RECRUITING","Olomouc","77111","Czechia",{"type":50,"coordinates":51},"Point",[52,53],17.25175,49.59552,{"lat":53,"lon":52},[56],{"name":32,"role":36,"phone":37,"phoneExt":29,"email":38},{"type":33,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":29,"oldOrganization":29},"Jakub Krejci","Assistant professor","100642210","effect-of-pre-exercise-inhalation-of-molecular-hydrogen-on-metabolic-response-during-graded-exercise-in-healthy-women-100642210",false,"NCT07644000","Effect of Pre-exercise Inhalation of Molecular Hydrogen on Metabolic Response During Graded Exercise in Healthy Women","Effect of Repeated Pre-exercise Inhalation of Molecular Hydrogen on Metabolic Response During Graded Exercise in Healthy Women: A Randomized, Double-blind, Placebo-controlled Crossover Trial","Inclusion Criteria:\n\n* Healthy female participants.\n* Regular menstrual cycle with exercise testing scheduled outside the menstrual phase.\n* Signed informed consent.\n\nExclusion Criteria:\n\n* Pregnancy or breastfeeding.\n* History or presence of cardiovascular disease.\n* History or presence of respiratory disease.\n* Regular use of medications affecting metabolism.\n* Use of dietary supplements affecting metabolism within 14 days prior to intervention.\n* Strenuous physical activity within 24 hours prior to exercise testing.\n* Any contraindication to exercise testing or study participation determined by a physician.",true,"FEMALE","18 Years","30 Years",{"count":72,"type":73},22,"ESTIMATED","INTERVENTIONAL",[76],"NA","The goal of this clinical trial is to evaluate if molecular hydrogen can reduce the metabolic response during graded exercise in healthy women aged 18-30 years. The main questions it aims to answer are:\n\n* Does molecular hydrogen reduce the respiratory exchange ratio?\n* Does molecular hydrogen reduce oxygen uptake?\n\nResearchers will compare molecular hydrogen to a placebo (ambient air containing no molecular hydrogen) to see if molecular hydrogen reduces the metabolic response.\n\nParticipants will:\n\n* Inhale molecular hydrogen for 60 minutes each day for 7 days.\n* Undergo an exercise testing twice after a two-week washout period.",[79],"Healthy Adult Females",[81,82],"molecular hydrogen","metabolic response","2026-06-22",{"date":85,"type":86},"2026-06-25","ACTUAL",{"date":83,"type":86},{"date":89,"type":73},"2026-12",{"name":5,"class":6},1]