[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100398423":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":26,"centralContacts":30,"locations":36,"responsibleParty":54,"collaborators":10,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":10,"eligibilityCriteria":62,"healthyVolunteers":58,"sex":63,"minAge":64,"maxAge":65,"enrollmentInfo":66,"targetDuration":10,"studyType":69,"phases":10,"briefSummary":70,"conditions":71,"keywords":75,"overallStatus":38,"whyStopped":10,"lastUpdateSubmitDate":83,"lastUpdatePostDateStruct":84,"startDateStruct":87,"completionDateStruct":89,"leadSponsor":91,"locationsCount":92},{"fullName":5,"class":6},"Peking University Third Hospital","OTHER",[8,12,17],{"label":9,"type":10,"description":11,"interventionNames":10},"NS Group",null,"Patients without pre-existing degeneration at L3\u002F4 segment will be classified into control group (NS group).",{"label":13,"type":10,"description":14,"interventionNames":15},"D Group","Patients with pre-existing disc factors (Pfirrmann grade≥3, Hiz or vacuum sign) at L3\u002F4 segment will be classified into group D.",[16],"Other: Pre-existing degenerative factors at adjacent segment",{"label":18,"type":10,"description":19,"interventionNames":20},"C Group","Patients with pre-existing canal stenosis factors (cerebrospinal fluid occlusion≥1) at L3\u002F4 segment will be classified into group C.",[16],[22],{"type":6,"name":23,"description":24,"armGroupLabels":25,"otherNames":10},"Pre-existing degenerative factors at adjacent segment","Pre-existing degenerative factors at adjacent segment, including disc factors and canal stenosis factors",[18,13],[27],{"name":28,"affiliation":5,"role":29},"Wei Shi Li, Dr.","PRINCIPAL_INVESTIGATOR",[31],{"name":32,"role":33,"phone":34,"phoneExt":10,"email":35},"Zhuo Ran Sun, Dr.","CONTACT","+8618610292513","puh3_szr@outlook.com",[37],{"facility":5,"status":38,"city":39,"state":40,"zip":41,"country":42,"countryCode":43,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"RECRUITING","Beijing","Beijing Municipality","100191","China","CN",{"type":45,"coordinates":46},"Point",[47,48],116.39723,39.9075,{"lat":48,"lon":47},[51],{"name":52,"role":33,"phone":10,"phoneExt":10,"email":53},"Da Zou, M.D.","zd_puth@163.com",{"type":55,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100398423","effect-of-pre-existing-adjacent-segment-degeneration-on-long-term-effectiveness-after-lumbar-fusion-surgery-100398423",false,"NCT04467944","Effect of Pre-existing Adjacent Segment Degeneration on Long-term Effectiveness After Lumbar Fusion Surgery","Effect of Pre-existing Adjacent Segment Degeneration on Long-term Effectiveness After Lumbar Fusion Surgery: a Prospective Cohort Study","Inclusion Criteria:\n\n* A clear diagnosis of lumbar spinal stenosis, and surgical level of L4- S1 (The levels to be operated on were decided by matching the clinical symptomatology with the radiological findings of the spinal levels that needed decompression);\n* Failed at least eight weeks conservative treatment;\n\nExclusion Criteria:\n\n* Unstable factors (slip, rotation, lateral bending, etc.) in adjacent segment L3\u002F4;\n* Preoperative sagittal and coronal imbalance of the spine;\n* Lumbar infection and\u002For tumor diseases;\n* A previous history of lumbar fusion surgery.","ALL","18 Years","80 Years",{"count":67,"type":68},210,"ESTIMATED","OBSERVATIONAL","This is a prospective single-center study. Patients requiring posterior lumbar interbody fusion (PLIF) for lumbar degenerative disease are prospectively enrolled and followed. Important adjacent pre-existing degeneration factors include discs degenerated, facets and ligamentum flavum tropism which could lead to spinal canal stenosis (SCS). This study will focus on the effects of pre- existing adjacent degeneration (disc factors and spinal canal stenosis factors) on long-term postoperative outcomes.",[72,73,74],"Degenerative Lumbar Spinal Stenosis","Degenerative Disc Disease","Degeneration Spine",[76,77,78,79,80,81,82],"Cerebrospinal fluid occlusion","Pre-existing degeneration","Spinal canal stenosis","Adjacent segment degeneration","Adjacent segment disease","High-intensity zone","Vacuum sign","2020-07-08",{"date":85,"type":86},"2020-07-13","ACTUAL",{"date":88,"type":86},"2018-01-01",{"date":90,"type":68},"2032-12-31",{"name":5,"class":6},1]