[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629802":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":18,"centralContacts":18,"locations":25,"responsibleParty":79,"collaborators":81,"id":85,"slug":86,"hasResults":87,"nctId":88,"briefTitle":89,"officialTitle":89,"acronym":90,"eligibilityCriteria":91,"healthyVolunteers":87,"sex":92,"minAge":93,"maxAge":18,"enrollmentInfo":94,"targetDuration":18,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":103,"overallStatus":114,"whyStopped":18,"lastUpdateSubmitDate":115,"lastUpdatePostDateStruct":116,"startDateStruct":119,"completionDateStruct":121,"leadSponsor":123,"locationsCount":124},{"fullName":5,"class":6},"Hôpital du Valais","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Intervention","EXPERIMENTAL","Intervention group: participation in a 12-16 week supervised exercise program consisting of three weekly sessions combining endurance and resistance training, delivered by trained physiotherapists.",[13],"Procedure: Preoperative Exercise Training",{"label":15,"type":16,"description":17,"interventionNames":18},"Control","NO_INTERVENTION","Control group: standard oncologic care without a structured exercise intervention.",null,[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":18},"PROCEDURE","Preoperative Exercise Training","The intervention consists of a structured, supervised pre-operative exercise training program initiated concomitantly with induction chemo- and\u002For immunotherapy and continued until 24-72 hours prior to surgery. The program is delivered in an outpatient setting and supervised by trained physiotherapists following a standardized protocol across study sites.\n\nParticipants randomized to the intervention group will complete three sessions per week, each lasting 45-60 minutes, for a total duration of 12 to 16 weeks depending on the length of induction therapy. Each session combines aerobic and resistance training components. Aerobic exercise is performed on a cycle ergometer at an initial intensity of approximately 60% of baseline VO₂peak, with progressive increases in duration and intensity aiming for 30-40 minutes at a Borg perceived exertion score of 4-6. Resistance training targets major upper and lower muscle groups using functional exercises.",[9],[26,47,63],{"facility":27,"status":18,"city":28,"state":29,"zip":30,"country":31,"countryCode":32,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Hôpitaux Universitaires de Genève","Geneva","Canton of Geneva","1205","Switzerland","CH",{"type":34,"coordinates":35},"Point",[36,37],6.14569,46.20222,{"lat":37,"lon":36},[40,45],{"name":41,"role":42,"phone":43,"phoneExt":18,"email":44},"Benoît Bédat, PD","CONTACT","+41795904475","benoit.bedat@hug.ch",{"name":41,"role":46,"phone":18,"phoneExt":18,"email":18},"PRINCIPAL_INVESTIGATOR",{"facility":48,"status":18,"city":49,"state":50,"zip":51,"country":31,"countryCode":32,"cosmosGeoPoint":52,"geoPoint":56,"contacts":57},"Centre Hospitalier Universitaire Vaudois","Lausanne","Canton of Vaud","1005",{"type":34,"coordinates":53},[54,55],6.63282,46.516,{"lat":55,"lon":54},[58,62],{"name":59,"role":42,"phone":60,"phoneExt":18,"email":61},"Michel Gonzalez, Professor","+41795563820","michel.gonzalez@chuv.ch",{"name":59,"role":46,"phone":18,"phoneExt":18,"email":18},{"facility":64,"status":18,"city":65,"state":66,"zip":67,"country":31,"countryCode":32,"cosmosGeoPoint":68,"geoPoint":72,"contacts":73},"Hôpital de Sion","Sion","Valais","1951",{"type":34,"coordinates":69},[70,71],7.35559,46.22739,{"lat":71,"lon":70},[74,78],{"name":75,"role":42,"phone":76,"phoneExt":18,"email":77},"Céline Forster, MD","+41276038944","celine.forster@hopitalvs.ch",{"name":75,"role":46,"phone":18,"phoneExt":18,"email":18},{"type":80,"investigatorFullName":18,"investigatorTitle":18,"investigatorAffiliation":18,"oldNameTitle":18,"oldOrganization":18},"SPONSOR",[82,84],{"name":83,"class":6},"University Hospital, Geneva",{"name":48,"class":6},"100629802","effect-of-pre-operative-exercise-training-on-cardiorespiratory-fitness-in-patients-with-locally-advanced-non-small-cell-lung-cancer-undergoing-induction-chemo-immunotherapy-followed-by-surgery---a-randomized-controlled-study-100629802",false,"NCT07479407","Effect of Pre-operative Exercise Training on Cardiorespiratory Fitness in Patients With Locally Advanced Non-small Cell Lung Cancer Undergoing Induction Chemo-immunotherapy Followed by Surgery - a Randomized Controlled Study","PREHAB","Inclusion Criteria:\n\n* Age ≥18 years.\n* Confirmed diagnosis of stage IIB, IIIA, IIIB or oligo-metastatic stage IV NSCLC.\n* Planned induction therapy with either chemotherapy, immunotherapy or a combination of immuno-chemotherapy followed by an anatomical pulmonary resection.\n* Absence of musculoskeletal conditions preventing safe physical exercise.\n* Absence of any history of uncontrolled or unstable cardiac disease.\n* Agreement to participate in the study by signing the study specific informed consent form.\n\nExclusion Criteria:\n\n* Pregnancy (confirmed by a test if applicable).\n* Induction therapy already initiated.\n* Inability to walk independently.\n* Lack of decision-making capacity.\n* Oxygen-dependency before the initiation of the induction protocol.\n* No capacity for discernment.\n* Does not speak French.","ALL","18 Years",{"count":95,"type":96},74,"ESTIMATED","INTERVENTIONAL",[99],"NA","The PREHAB study focuses on patients with locally advanced non-small cell lung cancer (NSCLC) undergoing neoadjuvant chemotherapy and\u002For immunotherapy prior to surgical resection. These systemic treatments frequently impair patients' physiological reserve, reduce physical fitness, and may occasionally lead to cancellation of surgery. Surgery itself carries a substantial risk of cardiorespiratory complications and long-term functional decline.\n\nThe primary objective of this study is to determine whether a supervised exercise program, initiated concomitantly with systemic therapy and continued until surgery, can improve cardiorespiratory fitness, surgical tolerance, and postoperative outcomes.\n\nA total of 74 patients will be randomly assigned to one of two groups: an \"intervention\" group participating in three weekly sessions of supervised endurance and resistance training for 12 to 16 weeks under the guidance of a physiotherapist, and a \"control\" group receiving usual care without a structured exercise program.\n\nThe primary endpoint will be peak oxygen uptake (VO₂peak). Secondary outcomes will include postoperative complication rates, length of hospital stay, pulmonary function, skeletal muscle mass, and quality of life.\n\nIntervention-related risks, primarily falls or overexertion, will be mitigated through professional supervision. This multicenter study, with recruitment scheduled to begin in 2026, is expected to provide robust evidence regarding the effectiveness of targeted exercise training in improving preoperative fitness and postoperative recovery in patients with locally advanced NSCLC.",[102],"Locally Advanced Non-small Cell Lung Cancer (NSCLC)",[104,105,106,107,108,109,110,111,112,113],"Non-small cell lung cancer","Locally advanced NSCLC","Neoadjuvant therapy","Immunotherapy","Prehabilitation","Exercise training","VO2peak","Cardiopulmonary exercise testing","Thoracic surgery","Postoperative complications","NOT_YET_RECRUITING","2026-03-16",{"date":117,"type":118},"2026-03-18","ACTUAL",{"date":120,"type":96},"2026-04",{"date":122,"type":96},"2029-04",{"name":5,"class":6},3]