[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100641294":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":12,"centralContacts":16,"locations":26,"responsibleParty":42,"collaborators":10,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":52,"eligibilityCriteria":53,"healthyVolunteers":48,"sex":54,"minAge":55,"maxAge":10,"enrollmentInfo":56,"targetDuration":10,"studyType":59,"phases":10,"briefSummary":60,"conditions":61,"keywords":64,"overallStatus":29,"whyStopped":10,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":76},{"fullName":5,"class":6},"Dicle University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":10},"This study includes a single group of liver transplant recipients.",null,"Patients aged 18 and over who underwent liver transplantation (LT) at Dicle University Faculty of Medicine Hospital between January 1, 2023, and January 28, 2026, provided written informed consent, and had preoperative carotid intima-media thickness measurements will be evaluated.",[13],{"name":14,"affiliation":5,"role":15},"AYHAN KAYDU, assoc. prof.","STUDY_DIRECTOR",[17,22],{"name":18,"role":19,"phone":20,"phoneExt":10,"email":21},"ibrahim andan, Asst. Prof.","CONTACT","+905059051167","ibrahimandan@hotmail.com",{"name":23,"role":19,"phone":24,"phoneExt":10,"email":25},"ayhan kaydu, Assoc. Prof.","+90 505 556 79 39","akaydu@hotmail.com",[27],{"facility":28,"status":29,"city":30,"state":10,"zip":31,"country":32,"countryCode":10,"cosmosGeoPoint":33,"geoPoint":38,"contacts":39},"Dicle University Faculty of Medicine, Department of Anesthesiology and Reanimation","RECRUITING","Diyarbakır","21280","Turkey (Türkiye)",{"type":34,"coordinates":35},"Point",[36,37],40.21721,37.91363,{"lat":37,"lon":36},[40],{"name":41,"role":19,"phone":20,"phoneExt":10,"email":21},"İbrahim Andan, asst. prof.",{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ayhan Kaydu","ASSOC PROF","100641294","effect-of-preoperative-cimt-on-hemodynamics-during-liver-transplantation-100641294",false,"NCT07660679","Effect of Preoperative CIMT on Hemodynamics During Liver Transplantation","The Effect of Preoperative Carotid Intima-Media Thickness on Intraoperative Hemodynamic Profile in Liver Transplant Patients","CIMT-LIVER","Inclusion Criteria:\n\n* Patients aged between 18 and 65 years\n* Scheduled for elective liver transplantation surgery\n* Completed preoperative carotid intima-media thickness (CIMT) ultrasonographic measurement\n* Patients with signed informed consent for data collection\n\nExclusion Criteria:\n\n* Patients undergoing emergency liver transplantation\n* History of previous carotid artery surgery or stenting\n* Known severe carotid artery stenosis (\\>70%)\n* Severe intraoperative hemodynamic instability prior to induction (e.g., active bleeding or shock)\n* Incomplete intraoperative advanced hemodynamic monitoring data or vasopressor records","ALL","18 Years",{"count":57,"type":58},54,"ESTIMATED","OBSERVATIONAL","Candidates for liver transplantation (CT) carry an increased risk of cardiovascular disease (CVD) due to underlying end-stage liver disease (ESHD) and immunosuppressive drugs used post-transplantation. CVD is a significant cause of long-term mortality after CT \\[1\\] \\[2\\]. Carotid Intima-Media Thickness (CIMT), a subclinical marker of atherosclerosis in the preoperative period, is a non-invasive method used to predict future CVD risk \\[3\\]. High CIMT indicates atherosclerosis and decreased arterial compliance. This can compromise organ perfusion and increase the risk of postoperative complications by increasing intraoperative blood pressure variability (BPV) during anesthesia induction and surgical stress in major surgeries such as CT. Studies investigating whether CIMT is an independent risk factor for perioperative hemodynamic instability in CT patients are limited. The aim of our study is to investigate the effect of CIMT values on intraoperative hemodynamic parameters. Secondary objectives are to determine the association of CIMT with the incidence of hypotension, vasopressor requirement, postoperative acute renal injury (ARI), and major cardiac adverse events (MCAE) after anesthesia induction.\n\nTheoretical Benefit: To make a significant contribution to the literature on the relationship between atherosclerosis and anesthesia management by determining whether CIMT is an independent predictor of perioperative hemodynamic instability in chemotherapy patients.\n\nPractical Benefit: To ensure the inclusion of CIMT measurement in the anesthesia risk assessment of chemotherapy candidates. Identifying patients with high CIMT will guide the implementation of more aggressive and targeted hemodynamic management strategies (e.g., more frequent invasive monitoring, proactive vasopressor use) during anesthesia induction and maintenance.",[62,63],"Liver Transplantation","Carotid Intima-media Thickness",[62,65,66],"Hemodynamics","Preoperative Assessment","2026-06-18",{"date":69,"type":70},"2026-06-23","ACTUAL",{"date":72,"type":70},"2026-02-11",{"date":74,"type":58},"2026-07-01",{"name":5,"class":6},1]