[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100571571":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":26,"responsibleParty":43,"collaborators":47,"id":57,"slug":58,"hasResults":59,"nctId":60,"briefTitle":61,"officialTitle":62,"acronym":63,"eligibilityCriteria":64,"healthyVolunteers":59,"sex":65,"minAge":66,"maxAge":67,"enrollmentInfo":68,"targetDuration":26,"studyType":71,"phases":72,"briefSummary":74,"conditions":75,"keywords":78,"overallStatus":81,"whyStopped":26,"lastUpdateSubmitDate":82,"lastUpdatePostDateStruct":83,"startDateStruct":86,"completionDateStruct":88,"leadSponsor":90,"locationsCount":26},{"fullName":5,"class":6},"Tongji Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"OP group","EXPERIMENTAL","Participants in this group will receive oxycodone and parecoxib sodium before surgical incision.",[13],"Drug: oxycodone and parecoxib sodium combinations",{"label":15,"type":16,"description":17,"interventionNames":18},"PP group","PLACEBO_COMPARATOR","Participants in this group will receive a placebo and parecoxib sodium before surgical incision.",[19],"Drug: Placebo and parecoxib sodium combinations",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DRUG","oxycodone and parecoxib sodium combinations","Participants will receive 0.1ml\u002Fkg oxycodone (1mg\u002Fml) and 2 ml parecoxib sodium (20 mg\u002Fml) combinations after the anesthesia induction but before the surgical incision. Oxycodone is administered 5 minutes after parecoxib sodium administration.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Placebo and parecoxib sodium combinations","Participants will receive 0.1ml\u002Fkg placebo (0.9% saline) and 2 ml parecoxib sodium (20 mg\u002Fml) combinations after the anesthesia induction but before the surgical incision. Placebo is administered 5 minutes after parecoxib sodium administration.",[15],[32],{"name":33,"affiliation":34,"role":35},"Luo Ailin","Department of Anesthesiology of Tongji hospital","PRINCIPAL_INVESTIGATOR",[37,41],{"name":33,"role":38,"phone":39,"phoneExt":26,"email":40},"CONTACT","86-027-83665480","alluo@hust.edu.cn",{"name":42,"role":38,"phone":26,"phoneExt":26,"email":26},"Li Shiyong",{"type":44,"investigatorFullName":45,"investigatorTitle":46,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"SPONSOR_INVESTIGATOR","Ailin Luo","Professor",[48,50,53,55],{"name":49,"class":6},"Jinhua Central Hospital",{"name":51,"class":52},"Minda Hospital of Hubei Minzu University","UNKNOWN",{"name":54,"class":52},"Taihe Hospital of Traditional Chinese Medicine",{"name":56,"class":52},"Qujing first people's Hospital","100571571","effect-of-preventive-analgesia-with-oxycodone-and-parecoxib-sodium-on-the-chronification-of-acute-post-operative-pain-100571571",false,"NCT06721988","Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Post-operative Pain","Exploring the Effect of Preventive Analgesia with Oxycodone and Parecoxib Sodium on the Chronification of Acute Pain in Adult Patients Underwent Laparoscopic-assisted Abdominal Major Surgery","AOPC","Inclusion Criteria:\n\n* ASA I\\~III；\n* BMI ranging from 18 to 28 kg\u002Fm²；\n* For elective laparoscopic-assisted major abdominal surgery under general anesthesia;\n* Estimated surgical duration (from incision to the last suture of the skin) was at least 2 hours.\n\nExclusion Criteria:\n\n* Pregnant or lactating patients;\n* Patients diagnosed with septic shock or multiple organ failure within 14 days;\n* Patients with preoperative severe electrolyte disorders;\n* Patients with stroke, transient ischemic attack, or other similar events within the past 3 months\n* Patients with unstable angina, myocardial infarction within the past 3 months; or presence of untreated arrhythmia or arrhythmia not well-controlled with treatment;\n* Patients with diabetes, uncontrolled blood glucose levels, or diabetes complications such as diabetic ketoacidosis, hyperosmolar coma, diabetes-related infections, diabetic nephropathy, retinopathy, diabetic cardiomyopathy, diabetic peripheral neuropathy, diabetic foot, etc. before the surgery;\n* Patients with severe liver dysfunction (Child-Pugh score \\> 6), renal dysfunction (GFR \\\u003C 90 ml\u002F(min•1.73m²));\n* Exploratory surgeries, day surgeries, or surgeries that only involve opening and closing the abdomen;\n* Blood pressure ≥180\u002F110 mmHg at rest (≥Grade 3 hypertension according to the 2020 ISH Hypertension Guidelines); or systolic blood pressure \\\u003C90 mmHg or mean blood pressure \\\u003C65 mmHg;\n* Patients participated in other drug trials within the past 3 months;\n* Patients with communication difficulties, inability to understand pain scores or patient-controlled intravenous analgesia;\n* Patients with consciousness disorders or other psychiatric illnesses;\n* Patients with a confirmed or suspected history of substance abuse or long-term use of anesthetic sedatives and analgesics;\n* Cancer patients have received neoadjuvant treatment or chemotherapy preoperatively;\n* Allergic to the drugs used in this trial and their components.","ALL","18 Years","65 Years",{"count":69,"type":70},1316,"ESTIMATED","INTERVENTIONAL",[73],"NA","The goal of this clinical trial is to learn if the administration of oxycodone for preventive analgesia works to reduce the chronification of acute postoperative pain in adult participants undergoing major abdominal surgery. The main question it aims to answer is:\n\n• Does administration of oxycodone before surgical incision reduce the occurrence of chronic pain or relieve the chronic pain symptoms 3 months after the operation? Researchers will compare oxycodone + parecoxib sodium to placebo + parecoxib sodium combinations to see if oxycodone works to reduce the chronification of acute postoperative pain.\n\nParticipants will:\n\n* Take oxycodone + parecoxib sodium or placebo + parecoxib sodium combinations before the surgical incision\n* Cooperate with the follow-up staffs and complete some checkups or tests within 3 months after the operation.",[76,77],"Oxycodone","Chronic Pain, Postoperative",[76,79,80],"Preventive analgesia","Chronification of acute postoperative pain","NOT_YET_RECRUITING","2024-12-03",{"date":84,"type":85},"2024-12-09","ACTUAL",{"date":87,"type":70},"2025-01-01",{"date":89,"type":70},"2027-04-30",{"name":45,"class":6}]