[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100605691":3},{"organization":4,"armGroups":7,"interventions":17,"overallOfficials":35,"centralContacts":40,"locations":46,"responsibleParty":60,"collaborators":63,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":71,"acronym":22,"eligibilityCriteria":72,"healthyVolunteers":73,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":22,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":48,"whyStopped":22,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Emory University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Nicotine Pouches group","EXPERIMENTAL","Participants will self-administer NPs that differ along two experimental factors: nicotine concentration (low \\[e.g., 3-4 mg\\] vs. high \\[e.g., 6-8 mg\\]) and pH level (low \\[\\\u003C8.5\\] vs. high \\[≥8.5\\]). Each participant will be exposed to all four NP conditions in randomized order, with one condition administered per visit.",[13,14,15,16],"Other: Nicotine pouch: Low dose","Other: Nicotine pouch: High dose","Other: Low pH","Other: High pH",[18,23,27,31],{"type":6,"name":19,"description":20,"armGroupLabels":21,"otherNames":22},"Nicotine pouch: Low dose","Nicotine pouch: 3-4 mg",[9],null,{"type":6,"name":24,"description":25,"armGroupLabels":26,"otherNames":22},"Nicotine pouch: High dose","Nicotine pouch: 6-8 mg",[9],{"type":6,"name":28,"description":29,"armGroupLabels":30,"otherNames":22},"Low pH","Nicotine pouch with low pH level \\[\\\u003C8.5\\]",[9],{"type":6,"name":32,"description":33,"armGroupLabels":34,"otherNames":22},"High pH","Nicotine pouch with high pH level \\[\\>8.5\\]",[9],[36],{"name":37,"affiliation":38,"role":39},"Dae Han, PhD","Rollins School of Public Health","PRINCIPAL_INVESTIGATOR",[41],{"name":42,"role":43,"phone":44,"phoneExt":22,"email":45},"Dae Hee Han, PhD","CONTACT","404-727-8742","dae.hee.han@emory.edu",[47],{"facility":38,"status":48,"city":49,"state":50,"zip":51,"country":52,"countryCode":53,"cosmosGeoPoint":54,"geoPoint":59,"contacts":22},"RECRUITING","Atlanta","Georgia","30322","United States","US",{"type":55,"coordinates":56},"Point",[57,58],-84.38798,33.749,{"lat":58,"lon":57},{"type":39,"investigatorFullName":61,"investigatorTitle":62,"investigatorAffiliation":5,"oldNameTitle":22,"oldOrganization":22},"Dae Hee Han","Assistant Professor",[64],{"name":65,"class":66},"National Institute on Drug Abuse (NIDA)","NIH","100605691","effect-of-product-characteristics-on-the-abuse-liability-of-nicotine-pouches-100605691",false,"NCT07165808","Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches","Inclusion Criteria:\n\n* Current established users of nicotine pouches (have used nicotine pouches in the past 30 days \\& currently use nicotine pouches every day or someday)\n* Positive cotinine test via saliva test strip\n* Those who are unmotivated to quit nicotine use\n* Read and speak English.\n* Poly-users of nicotine pouches, e-cigarettes (e.g., vape ≥20 days\u002Fmonth), and tobacco (e.g., ≥4 cigarettes\u002Fday for ≥2 years) will be eligible for participation\n\nExclusion Criteria\n\n* Planning to cut down or quit using nicotine in the next 30 days\n* Currently pregnant or breastfeeding\n* History of stroke, seizures, high blood pressure, heart disease\u002Fproblems, or cardiovascular disease contraindications for nicotine.",true,"ALL","21 Years","35 Years",{"count":78,"type":79},84,"ESTIMATED","INTERVENTIONAL",[82],"NA","The goal of this study is to assess the effects of nicotine concentration and its interplay with pH on sensory experience, product appeal, and abuse liability of NPs among young adults NP users.\n\nPrimary objective is to assess the effect of variation in nicotine concentration in nicotine pouches (NPs) and its interaction effect with pH level on three proximal outcomes of relevance to regulation: (1) sensory experience, (2) product appeal, and (3) abuse liability of NPs.",[85],"Nicotine Addiction",[85,87,88],"Oral Nicotine Pouches","Behavioral Responses","2026-02-25",{"date":91,"type":92},"2026-02-27","ACTUAL",{"date":94,"type":92},"2026-02-13",{"date":96,"type":79},"2028-01",{"name":5,"class":6},1]