[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100637877":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":15,"centralContacts":19,"locations":28,"responsibleParty":104,"collaborators":10,"id":108,"slug":109,"hasResults":110,"nctId":111,"briefTitle":112,"officialTitle":112,"acronym":10,"eligibilityCriteria":113,"healthyVolunteers":110,"sex":114,"minAge":115,"maxAge":10,"enrollmentInfo":116,"targetDuration":10,"studyType":119,"phases":10,"briefSummary":120,"conditions":121,"keywords":127,"overallStatus":57,"whyStopped":10,"lastUpdateSubmitDate":131,"lastUpdatePostDateStruct":132,"startDateStruct":135,"completionDateStruct":137,"leadSponsor":139,"locationsCount":140},{"fullName":5,"class":6},"Hospital Italiano de Buenos Aires","OTHER",[8,12],{"label":9,"type":10,"description":11,"interventionNames":10},"Patients whose protein intake at T0 is 1.2 g\u002Fkg\u002Fday or less.",null,"Patients in this group will be those whose documented protein intake on ICU day 5 is ≤1.2 g\u002Fkg\u002Fday. No additional interventions are administered as part of the study; classification is based solely on protein intake recorded in the medical record.",{"label":13,"type":10,"description":14,"interventionNames":10},"Patients whose protein intake at T0 is greater than or equal to 1.2 g\u002Fkg\u002Fday.","Patients in this group will be those whose documented protein intake on ICU day 5 is greater than 1.2 g\u002Fkg\u002Fday. No additional interventions are administered as part of the study; classification is based solely on protein intake recorded in the medical record.",[16],{"name":17,"affiliation":5,"role":18},"Ivan Alfredo Huespe, MS","STUDY_DIRECTOR",[20,25],{"name":17,"role":21,"phone":22,"phoneExt":23,"email":24},"CONTACT","+54949590200","850","ivan.huespe@hospitalitaliano.org.ar",{"name":26,"role":21,"phone":22,"phoneExt":23,"email":27},"Veronica Ester Monzon, MS","veronica.monzon@hospitalitaliano.org.ar",[29,41,56,66,81,93],{"facility":30,"status":31,"city":32,"state":32,"zip":10,"country":33,"countryCode":34,"cosmosGeoPoint":10,"geoPoint":10,"contacts":35},"Clinica Bazterrica","NOT_YET_RECRUITING","Buenos Aires","Argentina","AR",[36],{"name":37,"role":21,"phone":38,"phoneExt":39,"email":40},"Nicolas David Falcon, MD","+5491148211600","51724","nicolas.david.falcon@gmail.com",{"facility":42,"status":31,"city":32,"state":43,"zip":44,"country":33,"countryCode":34,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Hospital Alemán","Buenos Aires F.D.","C1118AAT",{"type":46,"coordinates":47},"Point",[48,49],-58.37723,-34.61315,{"lat":49,"lon":48},[52],{"name":53,"role":21,"phone":54,"phoneExt":10,"email":55},"Daniel Ignacio Ivulich, MD","+5491161859413","di.ivulich@gmail.com",{"facility":5,"status":57,"city":32,"state":43,"zip":58,"country":33,"countryCode":34,"cosmosGeoPoint":59,"geoPoint":61,"contacts":62},"RECRUITING","C1199ABB",{"type":46,"coordinates":60},[48,49],{"lat":49,"lon":48},[63],{"name":64,"role":21,"phone":65,"phoneExt":10,"email":24},"Ivan Alfredo Huespe, MD, MPh","+5493425382554",{"facility":67,"status":57,"city":68,"state":69,"zip":70,"country":33,"countryCode":34,"cosmosGeoPoint":71,"geoPoint":75,"contacts":76},"Hospital Privado Universitario de Córdoba","Córdoba","Córdoba Province","X5016KEH",{"type":46,"coordinates":72},[73,74],-64.18853,-31.40648,{"lat":74,"lon":73},[77],{"name":78,"role":21,"phone":79,"phoneExt":10,"email":80},"Emiliano Tornu, MD","+5491164073575","emilianocornu@gmail.com",{"facility":82,"status":57,"city":32,"state":83,"zip":84,"country":33,"countryCode":34,"cosmosGeoPoint":85,"geoPoint":87,"contacts":88},"Hospital Universitario Austral","Pilar","B1629AHJ",{"type":46,"coordinates":86},[48,49],{"lat":49,"lon":48},[89],{"name":90,"role":21,"phone":91,"phoneExt":10,"email":92},"Alicia Gira, MD","+5491126336442","aliciaroxanagira@gmail.com",{"facility":94,"status":57,"city":32,"state":95,"zip":96,"country":33,"countryCode":34,"cosmosGeoPoint":97,"geoPoint":99,"contacts":100},"Hospital Italiano sede San Justo Agustín Rocca","San Justo","C1198AAW",{"type":46,"coordinates":98},[48,49],{"lat":49,"lon":48},[101],{"name":102,"role":21,"phone":103,"phoneExt":10,"email":27},"Veronica Ester Monzon, MD","+5491165846854",{"type":105,"investigatorFullName":106,"investigatorTitle":107,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","Ivan A. Huespe","Chief, Section of Critical Care Research and Innovation, Hospital Italiano de Buenos Aires","100637877","effect-of-protein-dosage-on-persistent-acute-renal-failure-in-critically-ill-patients-100637877",false,"NCT07631221","Effect of Protein Dosage on Persistent Acute Renal Failure in Critically Ill Patients.","Inclusion Criteria:\n\n* Patients aged 18 years or older admitted to the ICU.\n* Patients receiving exclusive enteral or parenteral nutrition\n* Acute kidney injury or exacerbated chronic kidney disease according to KDIGO criteria (increase in creatinine greater than 0.3 mg\u002FdL in less than 48 hours or a 1.5-fold increase in baseline creatinine in 7 days)\n\nExclusion Criteria:\n\n* Patients diagnosed with chronic kidney disease with a creatinine clearance of less than 30 ml\u002Fmin\u002Fm2 or on dialysis at admission.\n* Patients with a history of kidney transplantation\n* Patients with severe liver disease (Child-Pugh score \\>7 points)\n* Patients with acute kidney injury undergoing renal replacement therapy at T0\n* BMI\\> 30","ALL","18 Years",{"count":117,"type":118},344,"ESTIMATED","OBSERVATIONAL","Background:\n\nAcute kidney injury (AKI) is common in critically ill patients and is associated with worse outcomes, including longer ICU stay, need for dialysis, and higher mortality. Patients with AKI often experience significant protein and calorie loss due to their illness and medical treatments. Providing the right amount of protein may help maintain muscle mass and improve recovery; however, consuming too much protein could potentially worsen kidney function. Current international guidelines recommend adequate protein intake, but the best dose remains uncertain, especially for patients with AKI.\n\nStudy Purpose:\n\nThis research will examine whether patients with AKI who receive a higher protein intake (greater than 1.2 g\u002Fkg\u002Fday) have different outcomes compared to those who receive a standard or lower protein intake (≤1.2 g\u002Fkg\u002Fday). The primary outcome is whether a higher protein intake leads to a longer recovery time from AKI or worsens kidney function.\n\nStudy Design:\n\nThis is a retrospective, multicenter study using data from five hospitals in Argentina. It is designed as a \"target trial emulation,\" meaning researchers will analyze existing patient data as if it were a randomized clinical trial. Patients will be included on the fifth day of their ICU stay and classified into two groups based on their protein intake on day 5:\n\n* Group 1 (Standard Protein): ≤1.2 g\u002Fkg\u002Fday\n* Group 2 (High Protein): \\>1.2 g\u002Fkg\u002Fday No additional interventions will be performed; data are collected from medical records.\n\nStudy Population:\n\nThe study will include adult patients (≥18 years) admitted to the ICU who are receiving exclusive enteral or parenteral nutrition and have AKI (or worsening chronic kidney disease) according to KDIGO criteria. Patients with advanced chronic kidney disease (creatinine clearance \\\u003C30 ml\u002Fmin\u002F1.73 m²) or undergoing hemodialysis at T0, previous kidney transplant, severe liver disease, or BMI \\>30 will be excluded.\n\nOutcomes:\n\n* Primary Outcome: Time to recovery of kidney function within 30 days, measured by creatinine returning close to baseline values.\n* Secondary Outcomes: Changes in blood urea levels, duration of renal replacement therapy (hemodialysis), ICU length of stay, and 30-day mortality.\n\nStatistical Approach:\n\nTo minimize bias, the study will use advanced statistical methods, including propensity score weighting, to ensure fair comparison between groups. Competing risks (such as death before kidney recovery) will be taken into account in the analysis.\n\nSignificance:\n\nThis study will provide important information about the safety and effectiveness of higher protein intake in critically ill patients with AKI. The findings may help guide nutritional strategies in the ICU, optimize kidney outcomes, and improve patient care.",[122,123,124,125,126],"Acute Kidney Failure","Critical Illness","Protein Intake","Nutritional Support","Mortality in Intensive Care Units",[128,123,124,129,130,125],"Acute Kidney Injury","Target Trial Emulation","Intensive Care Unit","2026-06-01",{"date":133,"type":134},"2026-06-05","ACTUAL",{"date":136,"type":134},"2025-09-15",{"date":138,"type":118},"2026-12-01",{"name":5,"class":6},6]