[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100616068":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":36,"locations":42,"responsibleParty":60,"collaborators":26,"id":62,"slug":63,"hasResults":64,"nctId":65,"briefTitle":66,"officialTitle":67,"acronym":26,"eligibilityCriteria":68,"healthyVolunteers":64,"sex":69,"minAge":70,"maxAge":71,"enrollmentInfo":72,"targetDuration":26,"studyType":75,"phases":76,"briefSummary":78,"conditions":79,"keywords":81,"overallStatus":45,"whyStopped":26,"lastUpdateSubmitDate":85,"lastUpdatePostDateStruct":86,"startDateStruct":89,"completionDateStruct":91,"leadSponsor":93,"locationsCount":94},{"fullName":5,"class":6},"Beni-Suef University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"PRP Group","EXPERIMENTAL","Patients in this group will undergo microlaryngoscopic removal of benign vocal fold lesions followed by an injection of platelet-rich plasma (PRP) into the superficial lamina propria (Reinke's space) just lateral to the excision site. This intervention aims to promote tissue regeneration, improve vocal fold healing, and enhance postoperative voice outcomes.",[13],"Procedure: Platelet-Rich Plasma (PRP) Injection after Microlaryngoscopic Surgery for PRP Group",{"label":15,"type":16,"description":17,"interventionNames":18},"Conventional Surgery Group","ACTIVE_COMPARATOR","Control (Conventional Surgery) Group\n\nRole: Control group for comparison.\n\nDescription: Patients in this group will undergo microlaryngoscopic removal of benign vocal fold lesions without PRP injection. Standard postoperative care will be provided. This arm serves as the baseline to assess the additional effect of PRP on voice recovery and healing.",[19],"Procedure: Conventional Microlaryngoscopic Surgery (Active Comparator)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"PROCEDURE","Platelet-Rich Plasma (PRP) Injection after Microlaryngoscopic Surgery for PRP Group","Platelet-Rich Plasma (PRP) Injection Patients in this group will undergo microlaryngoscopic removal of benign vocal fold lesions under general anesthesia. Following surgery, autologous PRP will be injected into the superficial lamina propria (Reinke's space), just lateral to the excision site, using a Chiba needle. The injection aims to promote tissue regeneration, improve postoperative healing, and enhance vocal quality. Care is taken to avoid the free edge of the vocal fold to minimize scarring or stiffness. The PRP is prepared fresh from the patient's blood on the day of injection.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Conventional Microlaryngoscopic Surgery (Active Comparator)","Patients in this group will undergo microlaryngoscopic removal of benign vocal fold lesions under general anesthesia without PRP injection. Standard postoperative care is provided. This group serves as a comparator to evaluate the additional effect of PRP on voice recovery.",[15],[32],{"name":33,"affiliation":34,"role":35},"Shaimaa Ahmed Bakia","Lecturer of Phoniatrics","PRINCIPAL_INVESTIGATOR",[37],{"name":38,"role":39,"phone":40,"phoneExt":26,"email":41},"Shaimaa Bakia, Lecturer","CONTACT","+201145335408","shaimaa.saleh@med.bsu.edu.eg",[43],{"facility":44,"status":45,"city":46,"state":47,"zip":48,"country":47,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Beni Suef Univesity hospital","RECRUITING","Banī Suwayf","Egypt","3220001","EG",{"type":51,"coordinates":52},"Point",[53,54],31.09785,29.07441,{"lat":54,"lon":53},[57],{"name":58,"role":39,"phone":59,"phoneExt":26,"email":41},"Shaimaa Bakia","01145335408",{"type":35,"investigatorFullName":61,"investigatorTitle":34,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Shaimaa A Bakia","100616068","effect-of-prp-injection-on-voice-recovery-after-benign-vocal-fold-surgery-100616068",false,"NCT07300800","Effect of PRP Injection on Voice Recovery After Benign Vocal Fold Surgery","Evaluating The Efficacy of Platelet Rich Plasma on Voice Outcomes Following Surgical Removal of Benign Vocal Fold Lesions","* Inclusion Criteria:\n\n  \\* Adults aged 18 to 50 years\n\n  \\* Diagnosis of a benign vocal fold lesion, including: Vocal fold polyps Vocal fold cysts Vocal fold nodules\n\n  \\* Failure to respond to conservative management, including one or more of the following: Voice rest, voice therapy\n* Exclusion Criteria:\n\n  * Age younger than 18 years or above 50\n  * Medically unfit for surgery","ALL","18 Years","50 Years",{"count":73,"type":74},64,"ESTIMATED","INTERVENTIONAL",[77],"NA","The goal of this clinical trial is to evaluate whether platelet-rich plasma (PRP) injections can improve voice outcomes after microlaryngosurgery in patients with benign vocal fold lesions. The main questions it aims to answer are:\n\nDoes postoperative PRP injection improve vocal quality compared to conventional surgery alone?\n\nDoes PRP injection reduce vocal fatigue and improve patients' voice-related quality of life?\n\nResearchers will compare 32 patients receiving PRP injections after surgical removal of lesions (intraoperative injection) to 32 patients undergoing conventional surgery without PRP to see if PRP enhances recovery and voice function.\n\nParticipants will:\n\nUndergo microlaryngosurgery to remove benign vocal fold lesions.\n\nReceive a PRP injection to the operated vocal fold and standard postoperative care.\n\nOr Standard postoperative care only.\n\nComplete voice assessments before surgery and at 1 and 3 months after surgery, including:\n\nAuditory perceptual evaluation (GRBAS scale) Videostroboscopy Acoustic and aerodynamic voice analysis Vocal Fatigue Index (VFI)\n\nAll participants will provide written consent and undergo standard preoperative assessments including medical history, ENT examination, laboratory tests, ECG, and anesthesia evaluation.",[80],"Benign Vocal Fold Lesions",[82,83,84],"vocal fold polyp","vocal fold nodules","vocal fold cyst","2026-05-29",{"date":87,"type":88},"2026-06-01","ACTUAL",{"date":90,"type":88},"2025-03-04",{"date":92,"type":74},"2026-07-30",{"name":5,"class":6},1]