[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100532734":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":30,"centralContacts":34,"locations":44,"responsibleParty":66,"collaborators":25,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":73,"acronym":25,"eligibilityCriteria":74,"healthyVolunteers":71,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":25,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":25,"overallStatus":46,"whyStopped":25,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Pennington Biomedical Research Center","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Continuous insulin at 40mU\u002Fm2\u002Fmin","ACTIVE_COMPARATOR","Paricipants will receive insulin infused continuously during the hyperinsulinemic euglycemic clamp test of insulin sensitivity.",[13],"Other: Continuous Insulin administration during hyperinsulinemic euglycemic clamp test",{"label":15,"type":16,"description":17,"interventionNames":18},"Pulsatile insulin at 40mU\u002Fm2\u002Fmin","EXPERIMENTAL","Participants will receive insulin infused every five minutes during the hyperinsulinemic euglycemic clamp test of insulin sensitivity",[19],"Other: Pulsatile Insulin administration during hyperinsulinemic euglycemic clamp test",[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Continuous Insulin administration during hyperinsulinemic euglycemic clamp test","Participants will receive insulin delivered continuously during the hyperinsulinemic euglycemic clamp test",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Pulsatile Insulin administration during hyperinsulinemic euglycemic clamp test","Participants will receive insulin delivered every five minutes during the hyperinsulinemic euglycemic clamp test",[15],[31],{"name":32,"affiliation":5,"role":33},"Candida Rebello, PhD","PRINCIPAL_INVESTIGATOR",[35,40],{"name":36,"role":37,"phone":38,"phoneExt":25,"email":39},"Candida J Rebello, Ph.D.","CONTACT","225-763-3159","Candida.Rebello@pbrc.edu",{"name":41,"role":37,"phone":42,"phoneExt":25,"email":43},"Frank L Greenway, MD","225-763-2578","Frank.Greenway@pbrc.edu",[45],{"facility":5,"status":46,"city":47,"state":48,"zip":49,"country":50,"countryCode":51,"cosmosGeoPoint":52,"geoPoint":57,"contacts":58},"RECRUITING","Baton Rouge","Louisiana","70808","United States","US",{"type":53,"coordinates":54},"Point",[55,56],-91.18747,30.44332,{"lat":56,"lon":55},[59,60,63],{"name":32,"role":37,"phone":38,"phoneExt":25,"email":39},{"name":61,"role":37,"phone":62,"phoneExt":25,"email":25},"Sara L Goff","2257630910",{"name":64,"role":65,"phone":25,"phoneExt":25,"email":25},"Frank L Greenway, PhD","SUB_INVESTIGATOR",{"type":33,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"Candida Rebello","Assistant Professor","100532734","effect-of-pulsatile-hormone-administration-on-insulin-action-100532734",false,"NCT06216665","Effect of Pulsatile Hormone Administration on Insulin Action","Inclusion Criteria:\n\n* Completion of the Motivate Study (NCT05649176)\n\nExclusion Criteria:\n\n* Non-completion of the end-of-study hyperinsulinemic euglycemic clamp test of the Motivate study","ALL","50 Years","75 Years",{"count":79,"type":80},12,"ESTIMATED","INTERVENTIONAL",[83],"NA","In humans, insulin is secreted in pulses from the pancreatic beta-cells, and these oscillations help to maintain fasting plasma glucose levels within a narrow normal range. Given the fluctuations in insulin concentrations, oscillations enhance precision of control. The hyperinsulinemic euglycemic clamp test (clamp) involves a continuous infusion of insulin and is the gold standard for measuring insulin sensitivity. In this study, insulin sensitivity measured using the standard clamp will be compared with a clamp in which the same total amount of insulin as the standard clamp is infused every five minutes instead of continuously.",[86],"Insulin Sensitivity","2025-01-14",{"date":89,"type":90},"2025-01-16","ACTUAL",{"date":92,"type":90},"2024-03-04",{"date":94,"type":80},"2025-12",{"name":5,"class":6},1]