[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100515876":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":31,"centralContacts":35,"locations":41,"responsibleParty":61,"collaborators":64,"id":67,"slug":68,"hasResults":69,"nctId":70,"briefTitle":71,"officialTitle":72,"acronym":26,"eligibilityCriteria":73,"healthyVolunteers":69,"sex":74,"minAge":75,"maxAge":76,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":86,"overallStatus":44,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Universidad Nacional Autonoma de Mexico","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active rTMS frequency at 10 Hz","EXPERIMENTAL","The intervention will be Repetitive Transcranial Magnetic Stimulation. Each patient will receive treatment stimulation in the left dorsolateral prefrontal cortex (lDLPFC) with a frequency of 10 Hz, that includes 2 sessions per day for 20 consecutive business days for 4 weeks. Each session will consist of the application of rTMS at a frequency of 10 Hz, to 100% of the motor threshold. The lDLPFC target will be determined using their resting state functional connectivity between anterior cingulate cortex and lDLPFC. Our algorithm performs a calculation of the individual localization of the participant's lDLPFC, which will be used for the whole study in that particular participant.",[13],"Device: Repetitive Transcranial Magnetic Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham rTMS frequency at 10 Hz","SHAM_COMPARATOR","The intervention will be Repetitive Transcranial Magnetic Stimulation (Sham). For this patients the coil will be located on the vertex. Each patient will receive sham stimulation with a frequency of 10 Hz, that includes 2 sessions per day for 20 consecutive business days for 4 weeks. Each session will consist of the application of rTMS at a frequency of 10 Hz, to 100% of the motor threshold. The lDLPFC target will be determined using their resting state functional connectivity between anterior cingulate cortex and lDLPFC. Our algorithm performs a calculation of the individual localization of the participant's lDLPFC, which will be used for the whole study in that particular participant.",[19],"Device: Repetitive Transcranial Magnetic Stimulation (Sham)",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Repetitive Transcranial Magnetic Stimulation","The investigators will use a Magstim Rapid 2 stimulator, Airfilled coil (AFC), 8 shape (magnetic field of 0.8 Teslas, 3Kg, pulse 0.5 ms)\n\nEach patient will receive high frequency 10 Hz stimulation at 100% of motor threshold over the dorsolateral prefrontal cortex (DLPFC) at 1500 pulses per session with 30 trains of 5 seconds and 0.5 ms stimuli and an inter-train distance of 15 seconds. In 2 daily sessions 4 days a week for 4 weeks.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Repetitive Transcranial Magnetic Stimulation (Sham)","The investigators will use a Magstim Rapid 2 stimulator, Airfilled coil (AFC), 8 shape (magnetic field of 0.8 Teslas, 3Kg, pulse 0.5 ms)\n\nEach patient will receive consistent treatment in 2 sessions a day for 20 consecutive business days for 4 weeks. The coil will be placed on the vertex target location.",[15],[32],{"name":33,"affiliation":5,"role":34},"Eduardo A Garza-Villarreal, MD, PhD","PRINCIPAL_INVESTIGATOR",[36],{"name":37,"role":38,"phone":39,"phoneExt":26,"email":40},"Alejandra Lopez Castro, MD, MSc","CONTACT","+524422381038","alejandraloc@comunidad.unam.mx",[42],{"facility":43,"status":44,"city":45,"state":46,"zip":47,"country":48,"countryCode":49,"cosmosGeoPoint":50,"geoPoint":55,"contacts":56},"Unidad de Resonancia Magnética","RECRUITING","Querétaro City","Querétaro","76230","Mexico","MX",{"type":51,"coordinates":52},"Point",[53,54],-100.38806,20.58806,{"lat":54,"lon":53},[57,59],{"name":37,"role":38,"phone":58,"phoneExt":26,"email":40},"4422381038",{"name":60,"role":34,"phone":26,"phoneExt":26,"email":26},"Eduardo A Garza Villarreal, MD, PhD",{"type":34,"investigatorFullName":62,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"Eduardo Adrian Garza Villarreal","Assistant Professor",[65],{"name":66,"class":6},"National Council of Science and Technology, Mexico","100515876","effect-of-repetitive-tms-on-executive-function-in-alcohol-use-disorder-100515876",false,"NCT05997212","Effect of Repetitive TMS on Executive Function in Alcohol Use Disorder","Effect of Repetitive Transcranial Magnetic Stimulation on the Executive Function in Alcohol Use Disorder","Inclusion Criteria:\n\n* Men and women of 25 to 59 years old\n* The reading level of at least 6th grade of primary (equivalent to fifth grade of elementary school).\n* Alcohol users with and AUDIT ≥ 20 puntos\n* Abstinence from alcohol consumption from 8 weeks to 5 years, with CIWA-Ar scale scores ≤ 9 points.\n* No disabling neuropsychiatric conditions (i.e. Schizophrenia)\n* No substance use disorders except alcohol and nicotine.\n* BrAC (Breath Alcohol) = 0.00 mg\u002Fdl in each of the assessments.\n* No traces of alcohol consumption using urine test strips.\n* No contraindications for TMS therapy.\n\nExclusion Criteria:\n\n* Individuals with symptoms of severe agitation or who are unable to cooperate in the study\n* History of epilepsy\n* Sudden onset of stroke, focal neurological findings such as hemiparesis, sensory loss, visual field deficits and lack of coordination.\n* Seizures or gait disturbances\n* History of severe psychiatric disorders.\n* Alterations in a conventional electroencephalogram.\n* Pacemakers or intracranial metallic objects.\n\nElimination criteria\n\n* At the subject's request\n* The presence of adverse incidents that deteriorate the subject's health and would limit continuation of rTMS treatment.\n* Exacerbation of cognitive or behavioral symptoms during treatment.","ALL","25 Years","59 Years",{"count":78,"type":79},44,"ESTIMATED","INTERVENTIONAL",[82],"NA","Alcohol Use Disorder (AUD) is a major public health problem that affects the physical, social, family, and mental integrity of the sufferer. Behavioral self-regulation is compromised in AUD, and a benefit has been reported with the application of repetitive transcranial magnetic stimulation and emotional self-regulation. The aim of this study is to investigate the efficacy of high-frequency rTMS to improve executive functions in patients in abstinence from AUD.",[85],"Alcohol Use Disorder",[87,88,89,90,91,92,93],"mri","rtms","tms","repetitive transcranial magnetic stimulation","mexico","magnetic resonance imaging","executive function","2025-02-06",{"date":96,"type":97},"2025-02-10","ACTUAL",{"date":99,"type":97},"2024-03-16",{"date":101,"type":79},"2026-11-01",{"name":5,"class":6},1]