[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100638839":3},{"organization":4,"armGroups":7,"interventions":10,"overallOfficials":21,"centralContacts":26,"locations":32,"responsibleParty":48,"collaborators":10,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":54,"acronym":10,"eligibilityCriteria":55,"healthyVolunteers":52,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":10,"studyType":62,"phases":10,"briefSummary":63,"conditions":64,"keywords":10,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":70,"lastUpdatePostDateStruct":71,"startDateStruct":74,"completionDateStruct":75,"leadSponsor":77,"locationsCount":78},{"fullName":5,"class":6},"Konya Meram State Hospital","OTHER",[8,12,15,18],{"label":9,"type":10,"description":11,"interventionNames":10},"Group\u002FCohort 1-Frailty",null,"Presence of frailty based on the Fried frailty phenotype.",{"label":13,"type":10,"description":14,"interventionNames":10},"Group\u002FCohort 2-Sarcopenia","Presence of sarcopenia based on preoperative clinical and ultrasonographic assessment.",{"label":16,"type":10,"description":17,"interventionNames":10},"Group\u002FCohort 3 - Frail and Sarcopenic Group","Geriatric patients who meet the criteria for both frailty and sarcopenia.",{"label":19,"type":10,"description":20,"interventionNames":10},"Group\u002FCohort 4 - Control Group","Geriatric patients who meet neither frailty nor sarcopenia criteria.",[22],{"name":23,"affiliation":24,"role":25},"Betül Kozanhan, M.D.","SBÜ Konya EAH","PRINCIPAL_INVESTIGATOR",[27],{"name":28,"role":29,"phone":30,"phoneExt":10,"email":31},"Betül kozanhan, M.D.","CONTACT","05055044808","betulkozanhan@gmail.com",[33],{"facility":34,"status":35,"city":36,"state":10,"zip":37,"country":38,"countryCode":10,"cosmosGeoPoint":39,"geoPoint":44,"contacts":45},"Betul Kozanhan","RECRUITING","Konya","42005","Turkey (Türkiye)",{"type":40,"coordinates":41},"Point",[42,43],32.48464,37.87135,{"lat":43,"lon":42},[46],{"name":34,"role":29,"phone":47,"phoneExt":10,"email":31},"(0332) 310 50 00",{"type":25,"investigatorFullName":34,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"Prof. Dr.","100638839","effect-of-sarcopenia-and-frailty-on-rocuronium-pharmacodynamics-in-geriatric-patients-100638839",false,"NCT07580144","Effect of Sarcopenia and Frailty on Rocuronium Pharmacodynamics in Geriatric Patients","Inclusion Criteria:\n\n* Scheduled to undergo elective surgery under general anesthesia requiring endotracheal intubation\n* Planned use of rocuronium for neuromuscular blockade\n* Quantitative neuromuscular monitoring planned during anesthesia\n* American Society of Anesthesiologists physical status I-III\n* Ability to provide written informed consent\n* Completion of preoperative frailty and sarcopenia assessment\n\nExclusion Criteria:\n\n* Emergency surgery\n* Known neuromuscular disease\n* History of allergy or contraindication to rocuronium, sugammadex\n* Severe hepatic insufficiency\n* Severe renal insufficiency\n* Use of drugs known to significantly affect neuromuscular transmission\n* Preoperative mechanical ventilation or intensive care unit admission\n* Inability to perform a frailty or sarcopenia assessment\n* Patients in whom quantitative neuromuscular monitoring cannot be properly performed\n* Refusal to participate in the study","ALL","65 Years","80 Years",{"count":60,"type":61},100,"ESTIMATED","OBSERVATIONAL","This prospective observational study aims to evaluate whether sarcopenia and frailty affect the pharmacodynamic profile of rocuronium in geriatric patients undergoing elective surgery under general anesthesia.",[65,66,67,68,69],"Sarcopenia","Frailty","Neuromuscular Blockade","Rocuronium","Pharmacodynamics","2026-05-13",{"date":72,"type":73},"2026-05-15","ACTUAL",{"date":70,"type":73},{"date":76,"type":61},"2026-08-05",{"name":5,"class":6},1]