[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100627475":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":30,"locations":36,"responsibleParty":61,"collaborators":25,"id":63,"slug":64,"hasResults":65,"nctId":66,"briefTitle":67,"officialTitle":68,"acronym":25,"eligibilityCriteria":69,"healthyVolunteers":65,"sex":70,"minAge":71,"maxAge":72,"enrollmentInfo":73,"targetDuration":25,"studyType":76,"phases":77,"briefSummary":79,"conditions":80,"keywords":84,"overallStatus":39,"whyStopped":25,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Masaryk University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Active TIS followed by Placebo TIS","EXPERIMENTAL","Participants first receive single-session active TIS targeting the striatum for approx. 20 minutes. Following a washout period, they receive placebo (sham) TIS.",[13,14],"Device: Active Temporal Interference Stimulation (TIS)","Device: Placebo \u002F Sham TIS",{"label":16,"type":10,"description":17,"interventionNames":18},"Placebo TIS followed by Active TIS","Participants first receive single-session placebo (sham) TIS for approx. 20 minutes. Following a washout period, they receive active TIS targeting the striatum.",[13,14],[20,26],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DEVICE","Active Temporal Interference Stimulation (TIS)","Non-invasive brain interference stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task.",[9,16],null,{"type":21,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Placebo \u002F Sham TIS","Placebo stimulation applied for approximately 20 minutes while the participant performs a sentence comprehension task.",[9,16],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Ľubomíra Nováková, Ph.D.","CONTACT","+420 549 497 766","lubomira.novakova@ceitec.muni.cz",[37],{"facility":38,"status":39,"city":40,"state":41,"zip":42,"country":43,"countryCode":25,"cosmosGeoPoint":44,"geoPoint":49,"contacts":50},"CEITEC MU (Central European Institute of Technology, Masaryk University)","RECRUITING","Brno","South Moravian","625 00","Czechia",{"type":45,"coordinates":46},"Point",[47,48],16.60796,49.19522,{"lat":48,"lon":47},[51,52,54,57,59],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},{"name":32,"role":53,"phone":25,"phoneExt":25,"email":25},"PRINCIPAL_INVESTIGATOR",{"name":55,"role":56,"phone":25,"phoneExt":25,"email":25},"Irena Rektorová, Prof. Ph.D.","SUB_INVESTIGATOR",{"name":58,"role":56,"phone":25,"phoneExt":25,"email":25},"Jiří Mekyska, Ph.D.",{"name":60,"role":56,"phone":25,"phoneExt":25,"email":25},"Jan Fousek, Ph.D.",{"type":62,"investigatorFullName":25,"investigatorTitle":25,"investigatorAffiliation":25,"oldNameTitle":25,"oldOrganization":25},"SPONSOR","100627475","effect-of-striatal-temporal-interference-stimulation-on-language-processing-in-neurodegenerative-diseases-100627475",false,"NCT07449117","Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases","Immediate Effects of Non-invasive Temporal Interference Stimulation Targeting Deep Fronto-Striatal Structures on Language Processing and Behavioral Performance in Patients With Neurodegenerative Diseases","Inclusion Criteria:\n\n* Possible or probable Mild Cognitive Impairment with Lewy Bodies (MCI-LB), in Parkinson's Disease (MCI-PD) or Amnestic Mild Cognitive Impairment (aMCI).\n\nExclusion Criteria:\n\n* Any severe psychiatric disorder.\n* History of other neurological diseases affecting the central nervous system.\n* Severe head trauma.\n* Uncompensated internal or oncological disease.\n* Presence of MRI-incompatible metal in the body (e.g., pacemaker).","ALL","60 Years","80 Years",{"count":74,"type":75},70,"ESTIMATED","INTERVENTIONAL",[78],"NA","The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative diseases.",[81,82,83],"Mild Cognitive Impairment (MCI) Amnestic","Lewy Body Disease With Mild Cognitive Impairment","Parkinson's Disease With Mild Cognitive Impairment",[85,86,87,88,89,90,91,92,93],"Temporal Interference Stimulation","Functional Magnetic Resonance Imaging","Sentence Comprehension","Language Processing","Brain Connectivity","Striatum","Fronto-striatal Circuit","Mild Cognitive Impairment","Neurodegenerative Diseases","2026-02-27",{"date":96,"type":97},"2026-03-04","ACTUAL",{"date":99,"type":75},"2026-03",{"date":101,"type":75},"2028-12",{"name":5,"class":6},1]