[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618450":3},{"organization":4,"armGroups":7,"interventions":23,"overallOfficials":35,"centralContacts":36,"locations":35,"responsibleParty":42,"collaborators":35,"id":46,"slug":47,"hasResults":48,"nctId":49,"briefTitle":50,"officialTitle":51,"acronym":35,"eligibilityCriteria":52,"healthyVolunteers":48,"sex":53,"minAge":54,"maxAge":35,"enrollmentInfo":55,"targetDuration":35,"studyType":58,"phases":59,"briefSummary":61,"conditions":62,"keywords":35,"overallStatus":64,"whyStopped":35,"lastUpdateSubmitDate":65,"lastUpdatePostDateStruct":66,"startDateStruct":69,"completionDateStruct":71,"leadSponsor":73,"locationsCount":35},{"fullName":5,"class":6},"University of Liege","OTHER",[8,15,19],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1 - Active tDCS Before Rehabilitation","EXPERIMENTAL","Active tDCS Before Rehabilitation",[13,14],"Device: tDCS","Device: Sham Transcranial Direct Current Stimulation (Sham tDCS)",{"label":16,"type":10,"description":17,"interventionNames":18},"Arm 2 - Active tDCS During Rehabilitation","Active tDCS During Rehabilitation",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Arm 3 - Active tDCS After Rehabilitation","Active tDCS After Rehabilitation",[13,14],[24,31],{"type":25,"name":26,"description":27,"armGroupLabels":28,"otherNames":29},"DEVICE","tDCS","Transcranial Direct Current Stimulation (tDCS) is delivered using a non-invasive electrical stimulation device that applies a low-intensity direct current (2 mA) through two saline-soaked sponge electrodes placed on the scalp. Each participant receives three stimulation sessions per day: one before, one during, and one after their rehabilitation session. In each randomized group, only one of these three daily stimulations is active, while the other two are sham (brief ramp-up and ramp-down without sustained current). The active stimulation lasts 20 minutes. Sham sessions mimic the initial sensations of stimulation to maintain blinding. Electrode placement is standardized according to the lesioned hemisphere. All participants receive 2 sets of five consecutive days (2 weeks) of this combined protocol alongside their usual rehabilitation program.",[9,16,20],[30],"Rehabilitation",{"type":25,"name":32,"description":33,"armGroupLabels":34,"otherNames":35},"Sham Transcranial Direct Current Stimulation (Sham tDCS)","Sham tDCS is delivered using the same device and electrode placement as active stimulation, but without administering a sustained electrical current. The device applies a brief ramp-up and ramp-down of current at the beginning and end of the session to mimic the initial sensations of active tDCS (e.g., tingling or warmth), after which no current is delivered. Each participant receives three tDCS sessions per day (before, during, and after rehabilitation), but only one is active; the other two are sham. Sham stimulation is used to maintain double-blinding and ensure that participants and assessors cannot distinguish between active and inactive sessions.",[9,16,20],null,[37],{"name":38,"role":39,"phone":40,"phoneExt":35,"email":41},"Stephen Bornheim, PhD, PT","CONTACT","003243233843","stephen.bornheim@uliege.be",{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":35,"oldOrganization":35},"PRINCIPAL_INVESTIGATOR","Bornheim Stephen","Prof.","100618450","effect-of-tdcs-timing-on-motor-recovery-in-acute-stroke-rehabilitation-100618450",false,"NCT07331779","Effect of tDCS Timing on Motor Recovery in Acute Stroke Rehabilitation","Timing Matters: Comparing Pre , Peri , and Post Rehabilitation tDCS in Acute Stroke Recovery","Inclusion Criteria:\n\n* Hospitalization for stroke rehabilitation Hospitalized in a stroke rehabilitation unit at CHU de Liège.\n\nConfirmed acute stroke Diagnosis of acute stroke (ischemic or hemorrhagic) confirmed by neuroimaging, according to local clinical practice.\n\nTime since stroke In the acute\u002Fsubacute phase, as defined in the protocol (e.g., within X days\u002Fweeks after stroke onset) - to be specified exactly as in your protocol.\n\nAge Age ≥ 18 years.\n\nCapacity to consent Able to understand the study information and provide written informed consent.\n\nMotor impairment of the upper limb Presence of motor deficit of the upper limb on the affected side, sufficient to perform the WMFT tasks (according to protocol thresholds, if specified).\n\nMedically stable Clinically stable and judged by the treating physician as able to participate in daily rehabilitation and tDCS sessions.\n\nExclusion Criteria:\n\n* Contraindications to tDCS or cranial stimulation\n\nImplanted electronic devices in the head or neck (e.g., deep brain stimulator, cochlear implant, implanted neurostimulator, pacemaker with leads near the head).\n\nMetal implants in the skull (excluding dental fillings) in the area of stimulation.\n\nLarge skull defect or craniectomy over the stimulation site.\n\nHistory of seizures History of epilepsy or unprovoked seizures not adequately controlled, if considered a contraindication to tDCS by the investigator.\n\nSevere cognitive or communication impairment Severe cognitive impairment, aphasia, or comprehension difficulties preventing understanding of the study or execution of the tasks, as judged by the investigator.\n\nSevere comorbidities Unstable medical conditions (e.g., uncontrolled cardiac, respiratory, metabolic, or systemic disease) that could interfere with participation or increase risk.\n\nSevere psychiatric disorder Current severe psychiatric illness (e.g., psychosis, severe untreated major depression) that may affect cooperation or safety, as judged by the investigator.\n\nSkin conditions at electrode sites Skin lesions, infections, severe dermatitis, or wounds at or near the planned electrode placement sites.\n\nConcurrent participation in another interventional trial Participation in another interventional clinical trial that could interfere with the outcomes or safety of this study.\n\nPregnancy Pregnancy or breastfeeding, if considered a contraindication according to local tDCS safety policy (optional, depending on your protocol stance).\n\nAny other reason Any condition or circumstance that, in the opinion of the investigator, makes the patient unsuitable for the study or unable to comply with the protocol.","ALL","18 Years",{"count":56,"type":57},60,"ESTIMATED","INTERVENTIONAL",[60],"NA","This randomized, double-blind, sham-controlled clinical trial investigates how the timing of transcranial direct current stimulation (tDCS) influences functional recovery during acute stroke rehabilitation. 198 hospitalized patients with confirmed acute stroke will be randomly assigned to one of three groups. Each day, all participants will receive three tDCS sessions: one before, one during, and one after their rehabilitation session. In each group, only one of these three daily stimulations is active, while the other two are sham, allowing a direct comparison of timing effects while maintaining blinding. All participants will complete 2 sets of five consecutive days of conventional rehabilitation combined with the tDCS protocol (2 weeks). Functional, sensory, psychological, and motor outcomes will be assessed at baseline and at the end of the intervention week. The study aims to determine whether the timing of tDCS application influences early post-stroke recovery and to inform the design of future confirmatory trials.",[63],"Acute Stroke","NOT_YET_RECRUITING","2026-06-30",{"date":67,"type":68},"2026-07-02","ACTUAL",{"date":70,"type":57},"2026-09-01",{"date":72,"type":57},"2029-12-31",{"name":5,"class":6}]