[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100643900":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":34,"responsibleParty":47,"collaborators":19,"id":50,"slug":51,"hasResults":52,"nctId":53,"briefTitle":54,"officialTitle":55,"acronym":19,"eligibilityCriteria":56,"healthyVolunteers":52,"sex":57,"minAge":58,"maxAge":59,"enrollmentInfo":60,"targetDuration":19,"studyType":63,"phases":64,"briefSummary":66,"conditions":67,"keywords":69,"overallStatus":74,"whyStopped":19,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Izmir Katip Celebi University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Transcutaneous electrical nerve stimulation (TENS)","EXPERIMENTAL","Participants with chronic post-stroke wrist flexor spasticity will receive sensory-level transcutaneous electrical nerve stimulation (TENS) applied over the paretic wrist flexor muscles during the intervention (B) phase. TENS will be delivered for 30 minutes using a symmetrical biphasic rectangular waveform with a frequency of 100 Hz and a pulse duration of 200 μs. Stimulation intensity will be adjusted to a clearly perceived sensory level without visible muscle contraction or discomfort. During the baseline (A) phase, no intervention will be administered.",[13],"Device: Transcutaneous electrical nerve stimulation (TENS)",[15],{"type":16,"name":9,"description":17,"armGroupLabels":18,"otherNames":19},"DEVICE","Transcutaneous electrical nerve stimulation (TENS) will be applied over the projection area of the paretic wrist flexor muscles (flexor carpi radialis) for 30 minutes. Stimulation parameters will consist of symmetrical biphasic rectangular pulses at a frequency of 100 Hz and a pulse duration of 200 μs. Stimulation intensity will be adjusted to produce a clearly perceived sensory sensation without visible muscle contraction or discomfort.",[9],null,[21],{"name":22,"affiliation":5,"role":23},"Korhan B Bayram","PRINCIPAL_INVESTIGATOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":19,"email":29},"Korhan B Bayram, M.D.","CONTACT","+905073066695","korbay@gmail.com",{"name":31,"role":27,"phone":32,"phoneExt":19,"email":33},"Büşra Candal, M.D.","+905436940747","busraalpppp@gmail.com",[35],{"facility":36,"status":19,"city":37,"state":38,"zip":39,"country":40,"countryCode":19,"cosmosGeoPoint":41,"geoPoint":46,"contacts":19},"Izmir Katip Çelebi University","Izmir","Karabağlar","35150","Turkey (Türkiye)",{"type":42,"coordinates":43},"Point",[44,45],27.13838,38.41273,{"lat":45,"lon":44},{"type":23,"investigatorFullName":48,"investigatorTitle":49,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Korhan Barış Bayram","Principal Investigator","100643900","effect-of-tens-on-spasticity-100643900",false,"NCT07669649","Effect of TENS on Spasticity","The Effect of Transcutaneous Electrical Nerve Stimulation on Spasticity: A Single-Subject Experimental Study","Inclusion Criteria:\n\n* Age between 18 and 70 years\n* Post-stroke wrist flexor spasticity scored as Grade 2 or 3 on the Australian Spasticity Assessment Scale (ASAS), specifically selecting patients whose passive stretch resistance (post-catch response) can be easily overcome to ensure accurate and unconfounded electrophysiological evaluation.\n* At least 6 months post-stroke (chronic phase).\n* Provision of voluntary, written informed consent prior to study enrollment.\n\nExclusion Criteria:\n\n* Age \\\u003C18 or \\>70 year\n* Contraindications to transcutaneous electrical nerve stimulation (e.g., implanted electronic devices, history of epilepsy, or localized skin lesions preventing electrode placement)\n* Concomitant wrist contracture or pain sufficient to impede clinical evaluation\n* Structural abnormalities of the elbow joint obstructing median nerve stimulation\n* Median nerve neuropathy or injury in the affected upper extremity.\n* Non-stable dosage of antispastic medications within the 2 weeks prior to baseline\n* Initiation of medications affecting nerve conduction (e.g., antidepressants, anticonvulsants, anesthetics) within the past month; patients on a stable dose for \\>1 month remain eligible\n* Botulinum toxin injection in the target spastic muscles within the preceding 3 months\n* History of neurolytic procedures targeting spasticity in the affected limb.\n* History of orthopedic or neurological surgery targeting spasticity in the affected limb\n* Cognitive impairment severe enough to compromise adherence to study protocols\n* Inability to maintain the required testing positions for the upper extremity joints (shoulder, elbow, forearm, and wrist)\n* Pregnancy or breastfeeding\n* Presence of active malignancy at or near the treatment area.","ALL","18 Years","70 Years",{"count":61,"type":62},4,"ESTIMATED","INTERVENTIONAL",[65],"NA","The purpose of this clinical trial is to evaluate whether Transcutaneous Electrical Nerve Stimulation (TENS) is effective in reducing spasticity in adults with post-stroke spasticity. The primary research question is whether TENS can reduce the severity of spasticity. The effectiveness of TENS will be assessed by comparing spasticity-related outcomes measured before, during, and after the intervention. Participants will first undergo a one-hour baseline monitoring period, during which assessments will be conducted at 10-minute intervals. This will be followed by a 30-minute TENS intervention and a two-hour follow-up period, with assessments performed every 10 minutes. One participant will repeat this protocol once daily for three consecutive days, whereas the remaining three participants will undergo the procedure on a single occasion.",[68],"Post Stroke Spasticity",[70,71,72,73],"Post stroke spasticity","Transcutaneous electrical nerve stimulation","Muscle reaction angle","H reflex","NOT_YET_RECRUITING","2026-06-20",{"date":77,"type":78},"2026-06-25","ACTUAL",{"date":80,"type":62},"2026-06",{"date":82,"type":62},"2027-06",{"name":5,"class":6},1]