[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100575323":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":10,"centralContacts":19,"locations":10,"responsibleParty":25,"collaborators":10,"id":28,"slug":29,"hasResults":30,"nctId":31,"briefTitle":32,"officialTitle":32,"acronym":33,"eligibilityCriteria":34,"healthyVolunteers":35,"sex":36,"minAge":37,"maxAge":38,"enrollmentInfo":39,"targetDuration":42,"studyType":43,"phases":10,"briefSummary":44,"conditions":45,"keywords":48,"overallStatus":52,"whyStopped":10,"lastUpdateSubmitDate":53,"lastUpdatePostDateStruct":54,"startDateStruct":57,"completionDateStruct":59,"leadSponsor":61,"locationsCount":10},{"fullName":5,"class":6},"Aydin Adnan Menderes University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"thoracal epidural anesthesia",null,"After appropriate local anesthesia, the patient will be placed in the epidural area while in a sitting position. The puncture will be performed between t6-t7 and t8-t9 with a midline approach with a \"loss of resistance\" specialist. The catheter is inserted into the epidural space 3-4 cm and the epidural lidocaine bolus (10 ml at 2% capacity) while the pain is in the supine region.",[13],"Other: strain echocardiography",[15],{"type":6,"name":16,"description":17,"armGroupLabels":18,"otherNames":10},"strain echocardiography","HR, MAP, SBP, and DBP will be recorded at baseline and 15 minutes after ESP block. Cardiac output (CO) will be calculated using echocardiographic data on stroke volume (SV) (measured from the LV outflow tract) and multiplied by HR. Two transthoracic 2D echocardiographic examinations will be performed immediately before and 15 minutes after TEA. The examinations include apical four-, two-, and three-chamber projections, mitral and aortic Doppler flow velocities. Standard measurements of left ventricular systolic function include left ventricular volumes (indexed to body surface area, BSA), left ventricular ejection fraction (LVEF) according to the modified Simpson rule, time and velocity integral in the left ventricular outflow tract (TVI-LVOT), and stroke volume (SV) (= π x LVOT radius2 x TVI-LVOT). Stroke volume index (SVI) will be calculated as SV\u002FBSA. Mitral and aortic Doppler flow profiles, left ventricular isovolumetric relaxation time, maximum flow velocity will be recorded for m",[9],[20],{"name":21,"role":22,"phone":23,"phoneExt":10,"email":24},"ferdi gülaştı","CONTACT","+905054929650","ferdigulasti@gmail.com",{"type":26,"investigatorFullName":21,"investigatorTitle":27,"investigatorAffiliation":5,"oldNameTitle":10,"oldOrganization":10},"PRINCIPAL_INVESTIGATOR","asst.prof.dr","100575323","effect-of-thoracic-epidural-anesthesia-on-left-ventricular-functions-a-strain-echocardiography-study-100575323",false,"NCT06770790","Effect of Thoracic Epidural Anesthesia on Left Ventricular Functions: A Strain Echocardiography Study","TEA-strain","Inclusion Criteria:\n\nElective payment options ASA I-III Ages 18-75\n\nExclusion Criteria:\n\n1. Refusal at enrollment\n2. Request for withdrawal from the study\n3. Inability to give informed consent\n4. Emergency surgery\n5. Bleeding diathesis\n6. Presence of contraindications to the LA agents used in this study\n7. Use of chronic opioids\n8. Psychiatric disorders\n9. Presence of infection at the injection site",true,"ALL","18 Years","75 Years",{"count":40,"type":41},23,"ESTIMATED","1 Day","OBSERVATIONAL","Post-thoracic surgery pain management thoracic epidural catheter is the most commonly used method.\n\nThoracic epidural anesthesia, in which cardiac sympathetic nerves (T1-T5) are involved in neural blockade, is the focus of our research. Many studies have shown a decrease in inotropic status (intrinsic function) after blockade of cardiac sympathetic innervation with thoracic epidural anesthesia (TEA).We want to examine the cardiac effects of TEA with strain echocardiography, which is an advanced echocardiography method. Therefore, we aimed to investigate the effect of TEA on left ventricular functions with strain echocardiography.",[46,47],"Thoracal Epidural Block","Echocardiography",[49,50,16,51],"thoracic epidural anesthesia","left ventricle","cardiac function","NOT_YET_RECRUITING","2025-01-07",{"date":55,"type":56},"2025-01-13","ACTUAL",{"date":58,"type":41},"2025-01-10",{"date":60,"type":41},"2026-02-05",{"name":5,"class":6}]