[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100596791":3},{"organization":4,"armGroups":7,"interventions":22,"overallOfficials":29,"centralContacts":34,"locations":43,"responsibleParty":66,"collaborators":28,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":28,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":77,"enrollmentInfo":78,"targetDuration":28,"studyType":81,"phases":82,"briefSummary":84,"conditions":85,"keywords":28,"overallStatus":45,"whyStopped":28,"lastUpdateSubmitDate":87,"lastUpdatePostDateStruct":88,"startDateStruct":91,"completionDateStruct":93,"leadSponsor":95,"locationsCount":96},{"fullName":5,"class":6},"Shengjing Hospital","OTHER",[8,14,18],{"label":9,"type":10,"description":11,"interventionNames":12},"Group A: sham stimulation + threshold pressure-loaded respiratory muscle training","EXPERIMENTAL","Sham Stimulation \"8\" coil at bilateral diaphragmatic cortical projections (2-3 cm ant. to coronal line, 3 cm lat. to midline). 80% MT intensity. Each pulse train: 3 bursts (50 Hz intra\u002F5 Hz inter), 2s on\u002F8s off. Total 1,200 pulses (600\u002Fside), 5 sess\u002Fwk × 20 sess. Coil at 90° to scalp to avoid cortical current.\n\nThreshold Pressure-Loaded RMT Saike trainer used. Pt. seated\u002Freclined, nasal clips occluding nares. Filter mouthpiece connected to valve; tight oral seal. Resistance: 30% of MIP\u002FMEP. 10 min inhale\u002Fexhale each, 20 min\u002Fd. Weekly MIP\u002FMEP reassessment to adjust resistance. 4 wk, 5 d\u002Fwk.",[13],"Device: Transcranial Magnetic Stimulation (TMS) Device \u002F Respiratory Training Device",{"label":15,"type":10,"description":16,"interventionNames":17},"Group B: iTBS + traditional respiratory training","iTBS Therapy 8-shape coil at bilateral diaphragmatic cortical projections (2-3 cm ant. to coronal line, 3 cm lat. to midline). 80% MT. Each pulse train: 3 bursts (50 Hz intra\u002F5 Hz inter), 2s on\u002F8s off. Total 1,200 pulses (600\u002Fside), 5 sess\u002Fwk × 20 sess.\n\nTraditional Respiratory Training 5 therapist-led maneuvers: Pursed-lip: inhale (3-4s) via nose, pause (1-2s), exhale (5-6s) with pursed lips (6-8 br\u002Fmin), 20 br\u002Fset.\n\nDiaphragmatic: seated\u002Fsupine, hands over umbilicus. Inhale to expand abdomen (3-5s), exhale to compress (6-8s). 4-6 br\u002Fmin, 20 br\u002Fset.\n\nForced exhale: inhale (3-5s), forcefully exhale \"ha\" (2-3s), 4-6 br\u002Fmin, 20 br\u002Fset.\n\nResisted inhale: supine, 1kg sandbag on umbilicus. Diaphragmatic breathing (4-6 br\u002Fmin), 20 br\u002Fset.\n\n3 sets\u002Fd, 5d\u002Fwk × 4wk.",[13],{"label":19,"type":10,"description":20,"interventionNames":21},"Group C: iTBS + threshold pressure-loaded respiratory muscle training","iTBS Therapy 8-shape coil at bilateral diaphragmatic cortical projections (2-3 cm ant. to coronal line, 3 cm lat. to midline). 80% MT. Each pulse train: 3 bursts (50 Hz intra\u002F5 Hz inter), 2s on\u002F8s off. Total 1,200 pulses (600\u002Fside), 5 sess\u002Fwk × 20 sess.\n\nThreshold Pressure-Loaded RMT Saike trainer used. Pt. seated\u002Freclined, nasal clips occluding nares. Filter mouthpiece connected to valve; tight oral seal. Resistance: 30% of MIP\u002FMEP. 10 min inhale\u002Fexhale each, 20 min\u002Fd. Weekly MIP\u002FMEP reassessment to adjust resistance. 4 wk, 5 d\u002Fwk.",[13],[23],{"type":24,"name":25,"description":26,"armGroupLabels":27,"otherNames":28},"DEVICE","Transcranial Magnetic Stimulation (TMS) Device \u002F Respiratory Training Device","Participants received group-specific interventions 5 days\u002Fweek for 4 weeks.",[9,15,19],null,[30],{"name":31,"affiliation":32,"role":33},"Jiang Xue","Rehabilitation Center of Shengjing Hospital, China Medical University","PRINCIPAL_INVESTIGATOR",[35,39],{"name":31,"role":36,"phone":37,"phoneExt":28,"email":38},"CONTACT","+86 18940254064","jiangxueruby@163.com",{"name":40,"role":36,"phone":41,"phoneExt":28,"email":42},"Zhang Di","+86 15291000208","zhangdi6952@163.com",[44],{"facility":32,"status":45,"city":46,"state":47,"zip":48,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"RECRUITING","Shenyang","Liaoning","110000","China","CN",{"type":52,"coordinates":53},"Point",[54,55],123.43278,41.79222,{"lat":55,"lon":54},[58,61,63,64],{"name":59,"role":36,"phone":60,"phoneExt":28,"email":38},"Xue Jiang","+86 189 4025 4064",{"name":62,"role":36,"phone":41,"phoneExt":28,"email":42},"Di Zhang",{"name":59,"role":33,"phone":28,"phoneExt":28,"email":28},{"name":62,"role":65,"phone":28,"phoneExt":28,"email":28},"SUB_INVESTIGATOR",{"type":33,"investigatorFullName":59,"investigatorTitle":67,"investigatorAffiliation":5,"oldNameTitle":28,"oldOrganization":28},"Associate Professor","100596791","effect-of-threshold-pressure-loaded-rmt--ttbs-on-respiratory-function-in-sci-patients-100596791",false,"NCT07050069","Effect of Threshold Pressure-Loaded RMT + tTBS on Respiratory Function in SCI Patients","The Effect of Threshold Pressure-loaded Respiratory Muscle Training Combined With Transcranial Intermittent Theta Burst Stimulation on Respiratory Function in Patients With Spinal Cord Injury","Inclusion Criteria:\n\n* Patients with spinal cord injury (SCI) meeting the 2019 revised International Standards for Neurological Classification of Spinal Cord Injury by the American Spinal Injury Association (ASIA), confirmed by CT\u002FMRI.\n* Aged 18-80 years.\n* Time since injury: 2 weeks to 6 months, with spinal shock resolved.\n* Injury level at T12 or above, ASIA Impairment Scale (AIS) grade A-C.\n* Patients providing written informed consent after study explanation.\n\nExclusion Criteria:\n\n* Patients with severe cardiorespiratory diseases (e.g., pneumothorax).\n* Unstable vital signs (e.g., hypotension, arrhythmia).\n* Cognitive\u002Fpsychiatric disorders precluding cooperation.\n* Requiring mechanical ventilation.\n* Congenital spinal\u002Flimb deformities.\n* Contraindications to magnetic stimulation: intracranial metal implants, pacemakers, etc.","ALL","18 Years","80 Years",{"count":79,"type":80},60,"ESTIMATED","INTERVENTIONAL",[83],"NA","The purpose of this clinical trial is to understand whether threshold pressure load respiratory muscle training combined with iTBS can effectively improve the respiratory function of SCI patients. The main questions it aims to answer are:\n\n* The impact of threshold pressure load respiratory muscle training on the respiratory function of SCI patients.\n* The impact of iTBS treatment at the cortical projection point of the diaphragm on the respiratory function of SCI patients.\n* Whether the combination of the above two treatment techniques is superior to single treatment.",[86],"Spinal Cord Injuries","2025-07-02",{"date":89,"type":90},"2025-07-03","ACTUAL",{"date":92,"type":90},"2024-12-25",{"date":94,"type":80},"2025-12-25",{"name":5,"class":6},1]