[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629241":3},{"organization":4,"armGroups":7,"interventions":21,"overallOfficials":38,"centralContacts":46,"locations":55,"responsibleParty":73,"collaborators":75,"id":80,"slug":81,"hasResults":82,"nctId":83,"briefTitle":84,"officialTitle":85,"acronym":33,"eligibilityCriteria":86,"healthyVolunteers":82,"sex":87,"minAge":88,"maxAge":33,"enrollmentInfo":89,"targetDuration":33,"studyType":92,"phases":93,"briefSummary":95,"conditions":96,"keywords":98,"overallStatus":103,"whyStopped":33,"lastUpdateSubmitDate":104,"lastUpdatePostDateStruct":105,"startDateStruct":108,"completionDateStruct":110,"leadSponsor":112,"locationsCount":113},{"fullName":5,"class":6},"Capital Medical University","OTHER",[8,16],{"label":9,"type":10,"description":11,"interventionNames":12},"tNGS group","EXPERIMENTAL","Lower respiratory tract samples collected (BALF, sputum); undergo targeted next-generation sequencing in addition to conventional microbiological testing; follow-up by telephone on day 30 (D30).",[13,14,15],"Diagnostic Test: Targeted next-generation sequencing","Diagnostic Test: Conventional microbiological testing","Other: Follow-up at Day 30",{"label":17,"type":18,"description":19,"interventionNames":20},"Control group","ACTIVE_COMPARATOR","Lower respiratory tract samples collected (BALF, sputum); undergo conventional microbiological testing; follow-up by telephone on day 30 (D30).",[14,15],[22,29,34],{"type":23,"name":24,"description":25,"armGroupLabels":26,"otherNames":27},"DIAGNOSTIC_TEST","Targeted next-generation sequencing","Bronchoalveolar lavage fluid (BALF) or sputum samples will be collected within 72 hours after randomization and sent for targeted next-generation sequencing (tNGS). The test results will be reported to the attending physician within 1-2 days.",[9],[28],"tNGS test",{"type":23,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"Conventional microbiological testing","Bronchoalveolar lavage fluid (BALF) or sputum samples will be collected within 72 hours after randomization and sent for conventional microbiological testing. The type of conventional microbiological testing will be determined by the attending physician, and test results will be reported in approximately one week",[17,9],null,{"type":6,"name":35,"description":36,"armGroupLabels":37,"otherNames":33},"Follow-up at Day 30","A telephone visit will be conducted on or around Day 30 for study participants who are discharged or transferred to another hospital due to disease exacerbation, to collect information on survival, ICU admissions, mechanical ventilation, and medical costs.",[17,9],[39,43],{"name":40,"affiliation":41,"role":42},"Binghuai Lu, M.D.","China-Japan Friendship Hospital","PRINCIPAL_INVESTIGATOR",{"name":44,"affiliation":41,"role":45},"Bin Cao, M.D.","STUDY_CHAIR",[47,52],{"name":48,"role":49,"phone":50,"phoneExt":33,"email":51},"Yeming Wang, M.D.","CONTACT","+86 84206264","wwyymm_love@163.com",{"name":53,"role":49,"phone":33,"phoneExt":33,"email":54},"Mengwei Yan","yanmengwei_happy@126.com",[56],{"facility":57,"status":33,"city":58,"state":59,"zip":60,"country":61,"countryCode":62,"cosmosGeoPoint":63,"geoPoint":68,"contacts":69},"China-Japan Friendship hospital","Beijing","Beijing Municipality","100029","China","CN",{"type":64,"coordinates":65},"Point",[66,67],116.39723,39.9075,{"lat":67,"lon":66},[70],{"name":71,"role":49,"phone":50,"phoneExt":33,"email":72},"Bin Cao","caobin_ben@163.com",{"type":42,"investigatorFullName":71,"investigatorTitle":74,"investigatorAffiliation":41,"oldNameTitle":33,"oldOrganization":33},"Professor",[76,77],{"name":41,"class":6},{"name":78,"class":79},"Beijing Municipal Health Commission","OTHER_GOV","100629241","effect-of-tngs-on-cap-patients-with-initial-treatment-failure-100629241",false,"NCT07472114","Effect of tNGS on CAP Patients With Initial Treatment Failure","Impact of Targeted Next-generation Sequencing on Hospitalized Patients With Community-acquired Pneumonia and Initial Treatment Failure","Inclusion Criteria:\n\n* Adults (age ≥ 18 years)\n* Diagnosed of community-acquired pneumonia\n* Initial treatment failure\n\nExclusion Criteria:\n\n* tNGS or mNGS already performed on respiratory samples during the current illness\n* Suspected lung abscess or empyema\n* Cerebral infarction within the past three months\n* Dysphagia\n* Nasopharyngeal carcinoma currently receiving radiotherapy\n* Tracheostomy\n* Long-term bedridden patients (ADL score ≤ 60)\n* Pathogens identified within the past 7 days that adequately explain the current clinical presentation\n* Bronchiectasis with large amounts of sputum and documented bacterial detection within the past six months\n* Inability to obtain eligible respiratory samples\n* CURB-65 score ≤ 1\n* Expected discharge or death within 48 hours","ALL","18 Years",{"count":90,"type":91},524,"ESTIMATED","INTERVENTIONAL",[94],"NA","This is a multicenter, randomized controlled trial designed to evaluate the impact of tNGS in patients with community-acquired pneumonia who experience initial treatment failure.",[97],"Community Acquired Pneumonia (CAP)",[99,100,101,102],"targeted next generation sequencing","community acquired pneumonia","RCT","initial treatment failure","NOT_YET_RECRUITING","2026-03-12",{"date":106,"type":107},"2026-03-16","ACTUAL",{"date":109,"type":91},"2026-04-10",{"date":111,"type":91},"2028-02-28",{"name":5,"class":6},1]