[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100534259":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":29,"responsibleParty":52,"collaborators":25,"id":56,"slug":57,"hasResults":58,"nctId":59,"briefTitle":60,"officialTitle":61,"acronym":62,"eligibilityCriteria":63,"healthyVolunteers":58,"sex":64,"minAge":65,"maxAge":66,"enrollmentInfo":67,"targetDuration":25,"studyType":70,"phases":71,"briefSummary":73,"conditions":74,"keywords":25,"overallStatus":31,"whyStopped":25,"lastUpdateSubmitDate":77,"lastUpdatePostDateStruct":78,"startDateStruct":81,"completionDateStruct":83,"leadSponsor":85,"locationsCount":86},{"fullName":5,"class":6},"IRCCS Centro Neurolesi Bonino Pulejo","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Real Stimulation","EXPERIMENTAL","Time A. Behavioral assessment using the Coma Recovery Scale-R (CRS-R). Time B. Transcranial Direct Current Stimulation (tDCS). Frontal stimulation for 20 minutes with the anode placed on the international electrode 10-20 position and the cathode on the right supraorbital region. Stimulation will be repeated once a day, 5 days a week, for 4 weeks. Time C. Behavioral assessment using the coma recovery scale-R (CRS-R). Rest Period 2 months.",[13],"Behavioral: Real Stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Placebo Stimulation","PLACEBO_COMPARATOR","Time A. Behavioral assessment using the Coma Recovery Scale-R (CRS-R). Time B. Transcranial Direct Current Stimulation (tDCS). Frontal stimulation for 5 seconds with the anode placed on the international electrode position and the cathode on the right supraorbital region. Stimulation will be repeated once a day, 5 days a week, for 4 weeks. · Time C: Behavioral assessment using the Coma Recovery Scale-R (CRS-R). Time D: Behavioral assessment using the coma Recovery Scale-R (CRS-R).",[19],"Behavioral: Placebo Stimulation",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"BEHAVIORAL","Time A: Behavioral assessment using the Coma Recovery Scale-R (CRS-R). · Time B:\n\nTranscranial Direct Current Stimulation (tDCS). Frontal stimulation for 20 minutes with the anode placed on the international electrode position and the cathode on the right supraorbital region. Stimulation will be repeated once a day, 5 days a week, for 4 weeks. · Time C. Behavioral assessment using the Coma Recovery Scale-R (CRS-R). Rest Period: 2 months.",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Time A: Behavioral assessment using the Coma Recovery Scale-R (CRS-R). Time B. Transcranial Direct Current Stimulation (tDCS). Frontal stimulation for 5 seconds with the anode placed on the electrode 10-20 position and the cathode on the right supraorbital region. Stimulation will be repeated once a day, 5 days a week, for 4 weeks. · Time C. Behavioral assessment using the Coma recovery Scale-R (CRS-R). Time D. Behavioral assessment using the Coma Recovery Scale-R (CRS-R).",[15],[30],{"facility":5,"status":31,"city":32,"state":33,"zip":34,"country":35,"countryCode":36,"cosmosGeoPoint":37,"geoPoint":42,"contacts":43},"RECRUITING","Messina","Italia","98124","Italy","IT",{"type":38,"coordinates":39},"Point",[40,41],15.55256,38.19394,{"lat":41,"lon":40},[44,49],{"name":45,"role":46,"phone":47,"phoneExt":25,"email":48},"Viviana Lo Buono, Dr","CONTACT","+3909060128185","viviana.lobuono@irccsme.it",{"name":50,"role":46,"phone":47,"phoneExt":25,"email":51},"Antonio Gangemi, Dr","antonio.gangemi@irccsme.it",{"type":53,"investigatorFullName":54,"investigatorTitle":55,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Viviana Lo Buono","Dr.","100534259","effect-of-transcranial-direct-current-stimulation-in-altered-states-of-consciousness-100534259",false,"NCT06236503","Effect of Transcranial Direct Current Stimulation in Altered States of Consciousness","Effect of Daily Transcranial Direct Current Stimulation on the Cognitive Evolution of Patients in an Altered State of Consciousness","tDCS-GCA","Inclusion Criteria:\n\n* Patients diagnosed with a minimally conscious state will be evaluated and stimulated, provided that written informed consent is obtained from a family member.\n\nExclusion Criteria:\n\npatients in coma patients with metallic brain implants, craniotomy or pacemaker","ALL","18 Years","75 Years",{"count":68,"type":69},100,"ESTIMATED","INTERVENTIONAL",[72],"NA","Transcranial Direct Current Stimulation (tDCS) is a non-invasive, painless brain stimulation treatment that uses low-intensity direct electrical currents to stimulate specific parts of the brain. Transcranial Direct Current Stimulation (tDCS) can both facilitate anodic stimulation and inhibit cathodic stimulation specific brain areas since many neurological and psychiatric disorders are connected to hypoactivity or hyperactivity in specific areas of the nervous system. This phenomenon is based on two processes: the reorganization of functional neural circuits and their reconstruction. In light of the studies mentioned above, it is presumed that Transcranial Direct Current Stimulation (tDCS) can be a valuable tool to facilitate the process of neuroplasticity in individuals with chronic neurological diseases and in patients with impaired consciousness following severe brain injury. A previous study demonstrated that a single session of transcranial direct current electrical stimulation could temporarily improve signs of consciousness in patients in a minimally conscious state (MCS)",[75,76],"Neurologic Disorder","Brain Injuries","2025-04-29",{"date":79,"type":80},"2025-05-01","ACTUAL",{"date":82,"type":80},"2023-01-10",{"date":84,"type":69},"2025-12-30",{"name":5,"class":6},1]