[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100628208":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":61,"collaborators":64,"id":68,"slug":69,"hasResults":70,"nctId":71,"briefTitle":72,"officialTitle":73,"acronym":26,"eligibilityCriteria":74,"healthyVolunteers":70,"sex":75,"minAge":76,"maxAge":26,"enrollmentInfo":77,"targetDuration":26,"studyType":80,"phases":81,"briefSummary":83,"conditions":84,"keywords":89,"overallStatus":93,"whyStopped":26,"lastUpdateSubmitDate":94,"lastUpdatePostDateStruct":95,"startDateStruct":98,"completionDateStruct":100,"leadSponsor":102,"locationsCount":103},{"fullName":5,"class":6},"Chinese PLA General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active taVNS Group","EXPERIMENTAL","Patients receiving active transcutaneous auricular vagus nerve stimulation during surgery.",[13],"Device: Active taVNS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham taVNS Group","SHAM_COMPARATOR","Patients receiving sham (placebo) stimulation with an identical device during surgery.",[19],"Device: Sham taVNS",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Active taVNS","Stimulation parameters: Amplitude 20 (mA), Frequency 20Hz, Pulse width 200μs, asymmetric biphasic square wave. A single 30-minute stimulation session is applied to the left auricular concha after anesthesia induction.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham taVNS","The sham device is identical in appearance, weight, indicator lights, and operation sounds to the active device but delivers no effective electrical current. It is applied to the left auricular concha for 30 minutes after anesthesia induction.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Weidong Mi","CONTACT","13381082966","wwdd1962@163.com",[38,54],{"facility":39,"status":26,"city":40,"state":26,"zip":26,"country":41,"countryCode":42,"cosmosGeoPoint":43,"geoPoint":48,"contacts":49},"Beijing Tiantan Hospital","Beijing","China","CN",{"type":44,"coordinates":45},"Point",[46,47],116.39723,39.9075,{"lat":47,"lon":46},[50],{"name":51,"role":34,"phone":52,"phoneExt":26,"email":53},"Yishuang Wu","+8615600950688","zznyx@outlook.com",{"facility":55,"status":26,"city":40,"state":26,"zip":26,"country":41,"countryCode":42,"cosmosGeoPoint":56,"geoPoint":58,"contacts":59},"First Medical Center of Chinese PLA General Hospital, Beijing, China.",{"type":44,"coordinates":57},[46,47],{"lat":47,"lon":46},[60],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},{"type":62,"investigatorFullName":33,"investigatorTitle":63,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Director (Cheif expert of National key research and development program of China 2018YFC2001900)",[65,66],{"name":39,"class":6},{"name":67,"class":6},"Peking University Shougang Hospital","100628208","effect-of-transcutaneous-auricular-vagus-nerve-stimulation-on-perioperative-negative-emotions-in-breast-cancer-surgery-patients-100628208",false,"NCT07458646","Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Perioperative Negative Emotions in Breast Cancer Surgery Patients","Effect of Intraoperative Transcutaneous Auricular Vagus Nerve Stimulation on Perioperative Negative Emotions in Patients Undergoing Breast Cancer Surgery: A Multicenter, Randomized, Double-Blind, Sham-Controlled Trial","Inclusion Criteria:\n\n* Aged ≥18 years. Scheduled for elective breast cancer surgery. ASA physical status I-III. Willing and able to provide informed consent.\n\nExclusion Criteria:\n\n* Preoperative MMSE score \\\u003C 24; severe communication barriers. History of diagnosed dementia, Parkinson's disease, schizophrenia, bipolar disorder, major depressive disorder, or long-term use of psychotropic drugs.\n\nSkin lesions, infection, or deformity of bilateral ears; history of ear surgery or nerve injury; allergy to electrode materials.\n\nSevere arrhythmia; implanted electronic devices (e.g., pacemaker, ICD). Participation in another interventional trial within 3 months. Other conditions deemed unsuitable by investigators.","ALL","18 Years",{"count":78,"type":79},232,"ESTIMATED","INTERVENTIONAL",[82],"NA","A multicenter, randomized, double-blind, sham-controlled trial to investigate the effects of a single session of intraoperative transcutaneous auricular vagus nerve stimulation (taVNS) on perioperative negative emotions (anxiety and depression), pain, nausea, sleep, and recovery in patients undergoing elective breast cancer surgery.",[85,86,87,88],"Depression","Postoperative","Anxiety","Breast Surgery",[90,91,85,87,92],"Transcutaneous Vagus Nerve Stimulation","Breast Cancer Surgery","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-03-04",{"date":96,"type":97},"2026-03-09","ACTUAL",{"date":99,"type":79},"2026-02-28",{"date":101,"type":79},"2027-02-28",{"name":5,"class":6},2]