[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100629597":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":26,"locations":30,"responsibleParty":42,"collaborators":46,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":26,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":57,"maxAge":58,"enrollmentInfo":59,"targetDuration":26,"studyType":62,"phases":63,"briefSummary":65,"conditions":66,"keywords":72,"overallStatus":77,"whyStopped":26,"lastUpdateSubmitDate":78,"lastUpdatePostDateStruct":79,"startDateStruct":82,"completionDateStruct":84,"leadSponsor":86,"locationsCount":87},{"fullName":5,"class":6},"Chinese PLA General Hospital","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Active taVNS Group","EXPERIMENTAL","Patients receiving active transcutaneous auricular vagus nerve stimulation during surgery.",[13],"Device: Active taVNS",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham taVNS Group","SHAM_COMPARATOR","Patients receiving sham (placebo) stimulation with an identical device during surgery.",[19],"Device: Sham taVNS Group",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Active taVNS","Stimulation parameters: Amplitude 20 (mA), Frequency 20Hz, Pulse width 200μs, asymmetric biphasic square wave. The current is gradually increased from 10mA to a level slightly below the individual's \"prickling\" sensation threshold (20-60mA). Stimulation is applied to the left auricular concha for 30 minutes after anesthesia induction and for another 30 minutes after cardiopulmonary bypass weaning.",[9],null,{"type":22,"name":15,"description":28,"armGroupLabels":29,"otherNames":26},"The sham device is identical in appearance, weight, indicator lights, and operation sounds to the active device but delivers no effective electrical current. It is applied to the left auricular concha at the same time points as the active group (30 minutes after induction and 30 minutes after CPB weaning).",[15],[31],{"facility":32,"status":26,"city":33,"state":26,"zip":26,"country":34,"countryCode":35,"cosmosGeoPoint":36,"geoPoint":41,"contacts":26},"First Medical Center of Chinese PLA General Hospital, Beijing, China.","Beijing","China","CN",{"type":37,"coordinates":38},"Point",[39,40],116.39723,39.9075,{"lat":40,"lon":39},{"type":43,"investigatorFullName":44,"investigatorTitle":45,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Weidong Mi","Director (Cheif expert of National key research and development program of China 2018YFC2001900)",[47],{"name":48,"class":6},"Navy General Hospital, Beijing","100629597","effect-of-transcutaneous-auricular-vagus-nerve-stimulation-on-postoperative-delirium-and-negative-emotions-in-patients-undergoing-cardiac-surgery-100629597",false,"NCT07476742","Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Delirium and Negative Emotions in Patients Undergoing Cardiac Surgery","Effect of Intraoperative Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Delirium and Negative Emotional States in Patients Undergoing Cardiac Surgery: A Multicenter, Randomized, Double-Blind, Sham-Controlled Trial","Inclusion Criteria:\n\n* Aged 18 to 85 years. Scheduled for elective cardiac surgery (e.g., CABG, valve replacement\u002Frepair). NYHA cardiac function class I-III. Willing and able to provide informed consent. Expected surgery duration ≥ 2 hours.\n\nExclusion Criteria:\n\n* Preoperative MMSE score \\\u003C 24; severe communication barriers. History of diagnosed delirium, dementia, Parkinson's disease, schizophrenia, bipolar disorder, major depressive disorder, or long-term use of psychotropic drugs.\n\nSkin lesions, infection, or deformity of bilateral ears; history of ear surgery or nerve injury; allergy to electrode materials.\n\nSevere arrhythmia; implanted electronic devices (e.g., pacemaker, ICD). Participation in another interventional trial within 3 months. Other conditions deemed unsuitable by investigators.","ALL","18 Years","85 Years",{"count":60,"type":61},270,"ESTIMATED","INTERVENTIONAL",[64],"NA","A multicenter, randomized, double-blind, sham-controlled trial to investigate the effects of intraoperative transcutaneous auricular vagus nerve stimulation (taVNS) on the incidence of postoperative delirium and negative emotional states (anxiety, depression) in patients undergoing elective cardiac surgery.",[67,68,69,70,71],"Postoperative Delirium (POD)","Postoperative","Anxiety","Depression","Cardiac Surgical Procedures",[73,74,75,70,69,76],"Transcutaneous Vagus Nerve Stimulation","Cardiac Surgery","Postoperative Delirium","Randomized Controlled Trial","NOT_YET_RECRUITING","2026-03-12",{"date":80,"type":81},"2026-03-17","ACTUAL",{"date":83,"type":61},"2026-02-28",{"date":85,"type":61},"2027-02-28",{"name":5,"class":6},1]