[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612952":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":26,"responsibleParty":37,"collaborators":26,"id":41,"slug":42,"hasResults":43,"nctId":44,"briefTitle":45,"officialTitle":45,"acronym":26,"eligibilityCriteria":46,"healthyVolunteers":43,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":26,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":26,"overallStatus":59,"whyStopped":26,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":26},{"fullName":5,"class":6},"Affiliated Hospital of Jiaxing University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"transcutaneous vagus nerve stimulation(taVNS)","ACTIVE_COMPARATOR","Patients received taVNS treatment immediately upon entering the AICU, with sessions occurring every 2 hours. A specialized taVNS stimulator device was used, and the left ear was cleaned with an alcohol swab or wet tissue before inserting an earplug with electrode contacts into the left ear, ensuring a snug fit. A second earplug was inserted into the right ear. The stimulation parameters were set as follows: continuous wave, frequency 20 Hz, pulse width 200 μs. Each treatment session lasted for 30 minutes.",[13],"Device: Transcutaneous auricular vagus nerve stimulation",{"label":15,"type":16,"description":17,"interventionNames":18},"Sham-stimulation","PLACEBO_COMPARATOR","The treatment protocol was identical to that of the taVNS group. Electrodes were placed on the left auricle. After the device was activated, it either did not deliver any current or only emitted a brief sub-threshold current to simulate the sensation of device activation, without producing continuous neural stimulation.",[19],"Device: Sham Transcutaneous auricular vagus nerve stimulation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","Transcutaneous auricular vagus nerve stimulation","Patients received taVNS treatment immediately upon entering the AICU, with sessions occurring every 2 hours. A specialized taVNS stimulator device was used, and the left auricle was cleaned with an alcohol swab or wet tissue before inserting an earplug with electrode contacts into the left ear, ensuring a snug fit. A second earplug was inserted into the right ear. The stimulation parameters were set as follows: continuous wave, frequency of 20 Hz, and pulse width of 200 μs. Each treatment session lasted for 30 minutes.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Sham Transcutaneous auricular vagus nerve stimulation","The treatment protocol was identical to that of the taVNS group. Electrodes were placed on the left auricle. After the device was turned on, it either did not output any current or only delivered a brief sub-threshold current to simulate the sensation of the device being activated, without producing continuous neural stimulation.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Mingzi An","CONTACT","18035193080","anmingzizi@163.com",{"type":38,"investigatorFullName":39,"investigatorTitle":40,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Qing-he Zhou","Clinical Professor","100612952","effect-of-transcutaneous-auricular-vagus-nerve-stimulation-on-postoperative-opioid-consumption-in-patients-undergoing-major-abdominal-surgery-100612952",false,"NCT07260266","Effect of Transcutaneous Auricular Vagus Nerve Stimulation on Postoperative Opioid Consumption in Patients Undergoing Major Abdominal Surgery","Inclusion Criteria:\n\n* Age between 18 and 85 years, regardless of gender\n* ASA physical status classification I-III\n* Scheduled for elective major abdominal surgery under general anesthesia, with postoperative admission to the AICU for monitoring\n* Anticipated duration of stay in the AICU is approximately 24 hours\n\nExclusion Criteria:\n\n* History of vagus nerve-related diseases (such as vasovagal syncope);\n* Severe arrhythmias or implanted electronic devices such as pacemakers;\n* Skin lesions, infections, or deformities at the site of external ear stimulation;\n* Long-term preoperative use of opioid medications or sedatives;\n* Allergy to study-related medications;","ALL","18 Years","85 Years",{"count":51,"type":52},108,"ESTIMATED","INTERVENTIONAL",[55],"NA","This study aims to design a prospective, double-blind, randomized controlled trial to compare the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on postoperative visceral pain in patients undergoing major abdominal surgery. Participants will be randomly assigned to receive either taVNS or sham stimulation. The total consumption of opioids and other analgesics within 24 hours post-surgery in the AICU will be recorded, along with follow-up assessments of pain scores and quality of recovery scores (Qor-15) at 24 hours postoperatively.",[58],"Pain Management","NOT_YET_RECRUITING","2025-12-08",{"date":62,"type":63},"2025-12-16","ACTUAL",{"date":65,"type":52},"2026-01-01",{"date":67,"type":52},"2027-12-30",{"name":5,"class":6}]