[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640249":3},{"organization":4,"armGroups":7,"interventions":19,"overallOfficials":25,"centralContacts":26,"locations":25,"responsibleParty":32,"collaborators":25,"id":36,"slug":37,"hasResults":38,"nctId":39,"briefTitle":40,"officialTitle":41,"acronym":42,"eligibilityCriteria":43,"healthyVolunteers":38,"sex":44,"minAge":45,"maxAge":46,"enrollmentInfo":47,"targetDuration":25,"studyType":50,"phases":51,"briefSummary":53,"conditions":54,"keywords":56,"overallStatus":59,"whyStopped":25,"lastUpdateSubmitDate":60,"lastUpdatePostDateStruct":61,"startDateStruct":64,"completionDateStruct":66,"leadSponsor":68,"locationsCount":25},{"fullName":5,"class":6},"College of Physicians and Surgeons Pakistan","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"2.5% Sodium Hypochlorite Group","EXPERIMENTAL","Participants undergoing single-visit root canal treatment using 2.5% sodium hypochlorite as the irrigation solution.",[13],"Drug: Sodium Hypochlorite Irrigation",{"label":15,"type":16,"description":17,"interventionNames":18},"5.25% Sodium Hypochlorite Group","ACTIVE_COMPARATOR","Participants undergoing single-visit root canal treatment using 5.25% sodium hypochlorite as the irrigation solution.",[13],[20],{"type":21,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"DRUG","Sodium Hypochlorite Irrigation","Participants undergoing single-visit root canal treatment will receive root canal irrigation using either 2.5% sodium hypochlorite or 5.25% sodium hypochlorite solution. Irrigation will be standardized by delivering 5 mL of the assigned solution per canal using a 30-gauge side-vented needle placed 2 mm short of the working length during chemo-mechanical preparation. The concentration of sodium hypochlorite will be the only variable between study groups.",[9,15],null,[27],{"name":28,"role":29,"phone":30,"phoneExt":25,"email":31},"Asad Ullah post graduate trainee","CONTACT","+923451505838","drasadkhan14@gmail.com",{"type":33,"investigatorFullName":34,"investigatorTitle":35,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Faiz ur rahman","Postgraduate Resident, Department of Operative Dentistry","100640249","effect-of-two-different-concentrations-of-sodium-hypochlorite-on-post-operative-pain-following-single-visit-root-canal-treatment-100640249",false,"NCT07618182","Effect of Two Different Concentrations of Sodium Hypochlorite on Post-Operative Pain Following Single-Visit Root Canal Treatment","Effect of Two Different Concentrations of Sodium Hypochlorite on Post-Operative Pain Following Single-Visit Root Canal Treatment: A Randomized Controlled Trial","NaOCl-RCT","Inclusion Criteria:\n\n* Adult patients aged 18-60 years Systemically healthy individuals Permanent teeth with closed apices requiring primary root canal treatment Teeth diagnosed with symptomatic\u002Fasymptomatic irreversible pulpitis or pulpal necrosis Patients able to understand the Visual Analog Scale Patients willing to provide informed consent and complete follow-up\n\nExclusion Criteria:\n\n* Uncontrolled systemic diseases Pregnant or breastfeeding women Allergy to sodium hypochlorite or local anesthetics Previously endodontically treated teeth Teeth with root resorption, vertical root fracture, or open apex Severe periodontal disease or mobility Use of analgesics, antibiotics, or anti-inflammatory drugs within previous 7 days","ALL","18 Years","65 Years",{"count":48,"type":49},116,"ESTIMATED","INTERVENTIONAL",[52],"NA","This randomized controlled trial aims to evaluate the effect of two different concentrations of sodium hypochlorite (2.5% and 5.25%) on post-operative pain following single-visit root canal treatment. A total of 116 participants requiring primary endodontic treatment will be randomly allocated into two groups according to irrigant concentration. Post-operative pain will be assessed using a 100-mm Visual Analog Scale at 6, 12, 24, and 48 hours after treatment. The study seeks to determine the concentration that provides optimal disinfection with minimal patient discomfort.",[55],"Post Operative Pain, Acute",[57,58],"Sodium Hypochlorite","Root Canal Treatment","NOT_YET_RECRUITING","2026-05-24",{"date":62,"type":63},"2026-06-01","ACTUAL",{"date":65,"type":49},"2026-07-05",{"date":67,"type":49},"2026-12-30",{"name":5,"class":6}]