[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100615647":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":25,"locations":29,"responsibleParty":50,"collaborators":25,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":59,"acronym":25,"eligibilityCriteria":60,"healthyVolunteers":56,"sex":61,"minAge":62,"maxAge":63,"enrollmentInfo":64,"targetDuration":25,"studyType":67,"phases":68,"briefSummary":70,"conditions":71,"keywords":73,"overallStatus":32,"whyStopped":25,"lastUpdateSubmitDate":75,"lastUpdatePostDateStruct":76,"startDateStruct":79,"completionDateStruct":81,"leadSponsor":83,"locationsCount":84},{"fullName":5,"class":6},"Fondazione IRCCS Policlinico San Matteo di Pavia","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Cynacol","EXPERIMENTAL","Cynacol (developed by BioDue S.p.A.) is a dietary supplement containing, artichoke dry extract, naringin, Silybum marianum dry extract, flaxseed oil, vitamin E and sunflower oil.",[13],"Dietary Supplement: Cynacol",{"label":15,"type":16,"description":17,"interventionNames":18},"Metacol","ACTIVE_COMPARATOR","Metacol (developed by BioDue S.p.A.) is a dietary supplement containing coenzyme Q10, monacolin k and flax seed oil.",[19],"Dietary Supplement: Metacol",[21,26],{"type":22,"name":9,"description":23,"armGroupLabels":24,"otherNames":25},"DIETARY_SUPPLEMENT","Cynacol (developed by BioDue S.p.A.) containing, artichoke dry extract, naringin, Silybum marianum dry extract, flaxseed oil, vitamin E and sunflower oil, 2 capsules\u002Fday after dinner for 90 days",[9],null,{"type":22,"name":15,"description":27,"armGroupLabels":28,"otherNames":25},"Metacol (developed by BioDue S.p.A.) containing coenzyme Q10, monacolin k and flaxseed oil, 2 capsules\u002Fday after dinner for 90 days",[15],[30],{"facility":31,"status":32,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Fondazione IRCCS Policlinico San Matteo","RECRUITING","Pavia","Lombardy","27100","Italy","IT",{"type":39,"coordinates":40},"Point",[41,42],9.15917,45.19205,{"lat":42,"lon":41},[45],{"name":46,"role":47,"phone":48,"phoneExt":25,"email":49},"Giuseppe Derosa, MD, PhD","CONTACT","+390382502614","g.derosa@smatteo.pv.it",{"type":51,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Giuseppe Derosa","Principal Investigator","100615647","effect-of-two-food-supplements-on-lipid-profile-in-patients-with-mild-hypercholesterolemia-100615647",false,"NCT07295327","Effect of Two Food Supplements on Lipid Profile in Patients With Mild Hypercholesterolemia","Randomized and Comparative Clinical Study on the Lipid-lowering Efficacy and Tolerability of Two Food Supplements in Mild Hypercholesterolemia","Inclusion Criteria:\n\n* age between 35-70 years\n* both genders\n* LDL-C levels between 115 and 190 mg\u002Fdl\n* subjects able to understand the informed consent and sign it before enrollment in the study\n\nExclusion Criteria:\n\n* personal history of cardiovascular disease or equivalent risk factors\n* Tg levels ≥ 400 mg\u002Fdl\n* obesity \\[body mass index (BMI) ≥ 30 kg\u002Fm²\\]\n* taking hypolipidemic drugs or supplements that affect lipid metabolism\n* diabetes mellitus\n* known thyroid, liver, kidney or muscle diseases\n* any medical or surgical condition that makes patient compliance with the study protocol complex or inconsistent\n* any known allergy or hypersensitivity to one or more components of the food supplements","ALL","35 Years","70 Years",{"count":65,"type":66},40,"ESTIMATED","INTERVENTIONAL",[69],"NA","The primary outcome is to evaluate the effect of Cynacol on the change in LDL-C levels compared to Metacol after 90 days of supplementation.\n\nThe secondary outcomes are to evaluate:\n\n\\- the change of TC, non-HDL cholesterol (non-HDL-C), apolipoprotein B (apoB), Tg, HDL-C levels after 90 days of supplementation with Cynacol compared to Metacol. The safety outcome is collection of the adverse events not related, related or possibly related to the study products.",[72],"Hypercholesterolemia",[72,74],"Food supplement","2025-12-08",{"date":77,"type":78},"2025-12-19","ACTUAL",{"date":80,"type":78},"2025-09-30",{"date":82,"type":66},"2026-03-31",{"name":5,"class":6},1]