[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100633015":3},{"organization":4,"armGroups":7,"interventions":27,"overallOfficials":33,"centralContacts":38,"locations":44,"responsibleParty":66,"collaborators":33,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":75,"eligibilityCriteria":76,"healthyVolunteers":77,"sex":78,"minAge":79,"maxAge":80,"enrollmentInfo":81,"targetDuration":33,"studyType":84,"phases":85,"briefSummary":87,"conditions":88,"keywords":92,"overallStatus":47,"whyStopped":33,"lastUpdateSubmitDate":97,"lastUpdatePostDateStruct":98,"startDateStruct":101,"completionDateStruct":103,"leadSponsor":105,"locationsCount":106},{"fullName":5,"class":6},"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","OTHER",[8,15,19,23],{"label":9,"type":10,"description":11,"interventionNames":12},"Young adult, vegetarian","EXPERIMENTAL","Young adult (18-23 years) with a vegetarian diet: exclusion of meat and fish\u002Fseafood, with \\> 70% of protein intake from plant source",[13,14],"Biological: Postprandial test","Biological: Amino acid bioavailability",{"label":16,"type":10,"description":17,"interventionNames":18},"Young, omnivore","Young adult with omnivorous: regular consumption of meat products, with meat intake \\> 3 times\u002Fweek and \\> 70% of protein intake from animal sources",[13,14],{"label":20,"type":10,"description":21,"interventionNames":22},"Old adult, vegetarian","Old adult (65-75 years) with vegetarian diet: exclusion of meat and fish\u002Fseafood, with \\> 70% of protein intake from plant sources",[13,14],{"label":24,"type":10,"description":25,"interventionNames":26},"Old adult, omnivorous","Old adult (65-75 years) with omnivorous diet: regular consumption of meat products, with meat intake \\> 3 times\u002Fweek and \\> 70% of protein intake from animal sources",[13,14],[28,34],{"type":29,"name":30,"description":31,"armGroupLabels":32,"otherNames":33},"BIOLOGICAL","Postprandial test","A meal containing pea protein labelled with 15N will be eaten by volunteers and dietary nitrogen kinetics will be measured in plasma urea, free amino acids and protein as well as in urinary urea.",[24,20,9,16],null,{"type":29,"name":35,"description":36,"armGroupLabels":37,"otherNames":33},"Amino acid bioavailability","A meal containing pea protein labelled with 2H will be given in a small portions every 30 minutes together with a dose of 13C-labelled amino acid and bioavailability of pea amino acid will be determined with the dual isotopic tracer method.",[24,20,9,16],[39],{"name":40,"role":41,"phone":42,"phoneExt":33,"email":43},"Juliane Calvez, PhD","CONTACT","+33189100875","juliane.calvez@agroparistech.fr",[45],{"facility":46,"status":47,"city":48,"state":33,"zip":33,"country":49,"countryCode":50,"cosmosGeoPoint":51,"geoPoint":56,"contacts":57},"Centre de Recherche sur Volontaire, Hopital Avicenne (AP-HP)","RECRUITING","Bobigny","France","FR",{"type":52,"coordinates":53},"Point",[54,55],2.45012,48.90982,{"lat":55,"lon":54},[58,59,63],{"name":40,"role":41,"phone":42,"phoneExt":33,"email":43},{"name":60,"role":41,"phone":61,"phoneExt":33,"email":62},"Suzette Maurinier","+33148957433","suzette.maurinier@aphp.fr",{"name":64,"role":65,"phone":33,"phoneExt":33,"email":33},"Robert Benamouzig, Pr","PRINCIPAL_INVESTIGATOR",{"type":65,"investigatorFullName":67,"investigatorTitle":68,"investigatorAffiliation":5,"oldNameTitle":33,"oldOrganization":33},"Robert Benamouzig","Professor","100633015","effect-of-vegetarien-diet-on-protein-digestibility-in-young-and-elderly-volunteers-100633015",false,"NCT07521189","Effect of Vegetarien Diet on Protein Digestibility in Young and Elderly Volunteers","Effect of a Vegetarian Diet on the Bioavailability of Amino Acids From Plant Protein in Healthy Young and Elderly Volunteers (VEGAA)","VEGAA","Inclusion Criteria:\n\n* Normal weight or overweight (18 \\\u003C BMI \\\u003C 30 kg·m-²)\n* Male or female\n* Aged 18-23 years (young groups) or 65-75 years (older groups)\n* Following an omnivorous diet (regular consumption of meat products, with meat intake \\> 3 times\u002Fweek and \\> 70% of protein intake from animal sources) or vegetarian diet (exclusion of meat and fish\u002Fseafood, with \\> 70% of protein intake from plant sources)\n* In good general health (WHO = 0)\n* Affiliated with a social security system\n* Free and informed consent, provided in writing after receiving the information required by the Public Health Code\n\nExclusion Criteria:\n\n* Adults under legal protection or unable to give informed consent (e.g., under guardianship, trusteeship, or legal protection)\n* Any known food allergy\n* Positive serology for HBsAg, anti-HBc, HCV, or HIV\n* Anemia: hemoglobin level \\\u003C 13 g\u002FdL in men and \\\u003C 12 g\u002FdL in women\n* Pregnant women or those who may be pregnant (based on a positive urine pregnancy test at inclusion)\n* Excessive alcohol consumption (\\> 2 drinks\u002Fday). Harmful alcohol use will be assessed by the investigator at inclusion.\n* Hypertension, diabetes, gastrointestinal, liver or kidney diseases, or severe heart disease. These conditions will be assessed by the investigator based on standard clinical evaluation and participants' self-reports at inclusion.\n* Hypertension: significant arterial hypertension according to the investigator, or systolic blood pressure ≥ 140 mmHg and\u002For diastolic blood pressure ≥ 90 mmHg at inclusion.\n* Diabetes: type 1 or type 2 diabetes, or fasting blood glucose \\> 1.25 g\u002FL.\n* Gastrointestinal disease: clinically significant gastrointestinal disorders (bleeding, vomiting, constipation\u002Fdiarrhea grade \\> 1) as judged by the investigator, any inflammatory bowel disease, or acute gastroenteritis in the month prior to the intervention.\n* Liver disease: any significant hepatic disorder according to the investigator, or ASAT\u002FALAT \\> 2.5 times the upper normal limit.\n* High-level athletes (\\> 8 hours of training per week)\n* Blood donation within 8 weeks prior to study start\n* Absence of free, informed, written consent after receiving the information required by the Public Health Code\n* Not affiliated with a social security system",true,"ALL","18 Years","75 Years",{"count":82,"type":83},48,"ESTIMATED","INTERVENTIONAL",[86],"NA","Plant proteins are usually less digestible than animal proteins, but they may benefit gut health through effects on the microbiome. The long-term impact of diets rich in plant products on protein digestion and metabolism is still unknown, especially in older adults with higher protein needs. This study aims to compare the digestion and use of pea proteins in young and older adults, both vegetarians and omnivores. Volunteers are divided into four groups: young omnivores, young vegetarians, older omnivores, and older vegetarians. They take part in two clinical investigation days. On the first day, nitrogen retention and protein metabolism is measured after consumption of a pea-based meal. On the second day, amino acid digestibility of pea is evaluated. These results will provide valuable data on how plant proteins are digested and metabolized depending on age and diet. They will also help determine whether aging reduces the availability of plant proteins. This knowledge is important to support nutritional strategies for populations with specific protein needs, such as older adults.",[89,90,91],"Vegetarian Diet","Elderly","Young Healthy Adults",[35,93,90,94,95,96],"Vegetarian diet","Plant protein","Protein utilization","Isotopic method","2026-04-07",{"date":99,"type":100},"2026-04-09","ACTUAL",{"date":102,"type":100},"2025-10-22",{"date":104,"type":83},"2026-12-31",{"name":5,"class":6},1]