[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100612845":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":34,"centralContacts":39,"locations":46,"responsibleParty":61,"collaborators":44,"id":65,"slug":66,"hasResults":67,"nctId":68,"briefTitle":69,"officialTitle":69,"acronym":27,"eligibilityCriteria":70,"healthyVolunteers":71,"sex":72,"minAge":73,"maxAge":44,"enrollmentInfo":74,"targetDuration":44,"studyType":77,"phases":78,"briefSummary":80,"conditions":81,"keywords":87,"overallStatus":49,"whyStopped":44,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"University of Crete","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"standard of care group","PLACEBO_COMPARATOR","Intraoperatively patients of the control group will be administered isotonic crystalloids (Lactated Ringer's, Plasma-Lyte) at a rate of 3 mL\u002Fkg\u002Fh.Fluid administration will continue at a rate of 3 mL\u002Fkg\u002Fh as per standard practice in the postanaesthesia care unit( PACU) also.In both groups, blood losses more than 300 ml will be replaced with a 5% albumin solution at a 1:1 ratio. Transfusion will be administered to maintain hemoglobin levels at 9 mg\u002FdL. Both groups will follow the same multimodal anesthesia-analgesia protocol, with restricted opioid use in accordance with the departmental routine.\n\nIntraoperative hypotension (systolic arterial pressure \\\u003C 90 mmHg or a decrease \\> 20% from baseline) will be managed with titrated norepinephrine infusion.",[13],"Other: Standard of Care (SOC)",{"label":15,"type":16,"description":17,"interventionNames":18},"vexus guided group","ACTIVE_COMPARATOR","The VExUS evaluation will be performed pre- and immediately post-intubation before one-lung ventilation initiation.\n\nUltrasound monitoring will be performed according to the VExUS protocol before positioning the patient in the lateral decubitus position. In patients with VExUS grade 0, a bolus of 250-500 mL (approximately 3 mL\u002Fkg) will be administered, followed by the infusion of crystalloids at a rate of 3 mL\u002Fkg\u002Fh. The inferior vena cava (IVC) diameter will be measured three times: once prior to anesthesia induction, once immediately after intubation, and once before patient emergence from anesthesia. In patients with VExUS grade 1, no bolus will be given, and only a fluid infusion at 3 mL\u002Fkg\u002Fh will be administered. In patients with VExUS grades 2 and 3, 10 mg of furosemide will be administered intravenously, followed by crystalloids infusion at a rate of 2 mL\u002Fkg\u002Fh.VExUS ultrasound will be repeated postoperatively in the PACU, following the same pattern of intervention.",[19],"Diagnostic Test: Venous Excess Ultrasound",[21,28],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIAGNOSTIC_TEST","Venous Excess Ultrasound","The VExUS protocol is a standardized point-of-care ultrasound examination that includes measurements of the inferior vena cava (IVC) diameter, combined with Doppler analysis of waveforms in the hepatic vein, portal vein, and renal veins. From this analysis, the presence of venous congestion-classified as mild or severe-or its absence is determined. A high VExUS score (grade 3) has been strongly associated with the occurrence of acute kidney injury in patients undergoing cardiac surgery and has more recently been linked to elevated right atrial pressure (RAP ≥ 12 mmHg). The protocol includes the following classification:\n\n* Grade 0: IVC \\\u003C 2 cm\n* Grade 1: IVC ≥ 2 cm, with normal or mildly abnormal waveforms in the hepatic, portal, and renal veins (mild congestion)\n* Grade 2: IVC ≥ 2 cm, with severely altered waveforms in at least one vein (moderate congestion)\n* Grade 3: IVC ≥ 2 cm, with severely altered waveforms in multiple veins (severe congestion)",[15],[27],"VEXUS",{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Standard of Care (SOC)","Intraoperatively patients of the control group will be administered isotonic crystalloids (Lactated Ringer's, Plasma-Lyte) at a rate of 3 mL\u002Fkg\u002Fh.Fluid administration will continue at a rate of 3 mL\u002Fkg\u002Fh as per standard practice in the PACU.",[9],[33],"standard of care",[35],{"name":36,"affiliation":37,"role":38},"Alexandra Papaioannou, Professor of Anaesthesiology","Medical School, University of Crete","STUDY_CHAIR",[40],{"name":41,"role":42,"phone":43,"phoneExt":44,"email":45},"Alexandros Bogas Manouselis, Resident of Anaesthesiology","CONTACT","+306947545446",null,"bogas.alexandros@gmail.com",[47],{"facility":48,"status":49,"city":50,"state":51,"zip":52,"country":53,"countryCode":54,"cosmosGeoPoint":55,"geoPoint":60,"contacts":44},"University General Hospital of Heraklion","RECRUITING","Heraklion","Crete","71500","Greece","GR",{"type":56,"coordinates":57},"Point",[58,59],25.14341,35.32787,{"lat":59,"lon":58},{"type":62,"investigatorFullName":63,"investigatorTitle":64,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"PRINCIPAL_INVESTIGATOR","Alexandros Bogas","Alexandros Bogas Manouselis","100612845","effect-of-vexus-ultrasound-protocol-venous-excess-ultrasound-on-perioperative-fluid-management-on-the-incidence-of-postoperative-pulmonary-complications-and-postoperative-acute-kidney-injury-in-patients-undergoing-thoracic-surgery-100612845",false,"NCT07258875","Effect of VExUS Ultrasound Protocol (Venous Excess Ultrasound) on Perioperative Fluid Management, on the Incidence of Postoperative Pulmonary Complications and Postoperative Acute Kidney Injury in Patients Undergoing Thoracic Surgery","Inclusion Criteria:\n\n* Adults \\>18 years undergoing video assisted thoracic surgery\u002F lobectomy requiring one-lung ventilation.\n\nExclusion Criteria:\n\n* Refusal to participate.\n* Pneumonectomy.\n* Young athletes (risk of physiologically large IVC \\>2 cm).\n* Moderate-severe tricuspid regurgitation, moderate to severe pulmonary hypertension\n* Heart failure with reduced ejection fraction, EF\\\u003C35%\n* Portal hypertension, portal vein thrombosis, or liver cirrhosis.\n* Stage 4 or end-stage chronic kidney disease (eGFR \\\u003C30 mL\u002Fmin\u002F1.73 m² or dialysis).\n* Transfusion with more than 2 packed red blood cells unit perioperatively (intraoperatively, in the PACU, in the ward)",true,"ALL","18 Years",{"count":75,"type":76},230,"ESTIMATED","INTERVENTIONAL",[79],"NA","This study aims to investigate the effect of a VExUS ultrasound guided protocol of perioperative fluid management within a goal-directed therapy framework, on postoperative respiratory complications, and the occurrence of acute kidney injury (AKI) in patients undergoing thoracic surgery.",[82,83,84,85,86],"Thoracic Surgery With One-lung Ventilation","VExUS","Fluid Management","Acute Kidney Injury","Postoperative Pulmonary Complications (PPCs)",[88],"VExUS, fluid management, pulmonary complications, acute kidney injury, thoracic surgery, one lung ventilation","2025-11-20",{"date":91,"type":92},"2025-12-02","ACTUAL",{"date":94,"type":92},"2024-11-27",{"date":96,"type":76},"2029-11-01",{"name":5,"class":6},1]