[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100618774":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":56,"collaborators":60,"id":69,"slug":70,"hasResults":71,"nctId":72,"briefTitle":73,"officialTitle":74,"acronym":26,"eligibilityCriteria":75,"healthyVolunteers":71,"sex":76,"minAge":77,"maxAge":78,"enrollmentInfo":79,"targetDuration":26,"studyType":82,"phases":83,"briefSummary":85,"conditions":86,"keywords":26,"overallStatus":40,"whyStopped":26,"lastUpdateSubmitDate":89,"lastUpdatePostDateStruct":90,"startDateStruct":93,"completionDateStruct":95,"leadSponsor":97,"locationsCount":98},{"fullName":5,"class":6},"Second Affiliated Hospital of Wenzhou Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Vitamin A Supplementation plus Nutritional Education","EXPERIMENTAL","1. Dietary Supplement: A daily oral dose of 2000 IU Vitamin A (as retinyl palmitate or acetate) for 6 consecutive months.\n2. Behavioral: Nutritional Education: A one-time, standardized educational session at baseline delivered by a study dietitian. The session covers principles of a balanced diet for bone health, with a focus on food sources rich in vitamin A.",[13],"Dietary Supplement: Vitamin A",{"label":15,"type":16,"description":17,"interventionNames":18},"Nutritional Education Only","ACTIVE_COMPARATOR","1. Behavioral: Nutritional Education: An identical one-time, standardized educational session and materials as provided to Arm 1.\n2. No study-provided vitamin A supplements will be administered.",[19],"Behavioral: Nutritional Education",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DIETARY_SUPPLEMENT","Vitamin A","Vitamin A supplements plus Nutritional Education",[9],null,{"type":28,"name":29,"description":15,"armGroupLabels":30,"otherNames":26},"BEHAVIORAL","Nutritional Education",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Xiangyang Wang, MD","CONTACT","86-13506663458","Xiangyangwang@wmu.edu.com",[38],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"The Second Affiliated Hospital of Wenzhou Medical University","RECRUITING","Wenzhou","Zhejiang","325000","China","CN",{"type":47,"coordinates":48},"Point",[49,50],120.66682,27.99942,{"lat":50,"lon":49},[53,55],{"name":33,"role":34,"phone":54,"phoneExt":26,"email":36},"13506663458",{"name":26,"role":34,"phone":26,"phoneExt":26,"email":36},{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Xiangyang Wang","M.D., Chief physician, Doctorial superviso",[61,63,65,67],{"name":62,"class":6},"The Children's Hospital of Zhejiang University School of Medicine",{"name":64,"class":6},"Ningbo No. 1 Hospital",{"name":66,"class":6},"Ningbo No.2 Hospital",{"name":68,"class":6},"The Third Affiliated Hospital of Wenzhou Medical University","100618774","effect-of-vitamin-a-supplementation-on-idiopathic-scoliosis-100618774",false,"NCT07335991","Effect of Vitamin A Supplementation on Idiopathic Scoliosis","Effect of Vitamin A Supplementation on the Onset and Progression of Idiopathic Scoliosis: A Prospective, Single-Blind, Randomized Controlled Trial","Inclusion Criteria:\n\n1. Age between 6 and 15 years.\n2. Biochemically confirmed vitamin A deficiency (serum retinol \\\u003C 0.20 mg\u002FL) or insufficiency (serum retinol 0.20-0.29 mg\u002FL).\n3. Has undergone radiographic evaluation (standing full-spine X-ray) for idiopathic scoliosis at the initial clinic visit.\n4. Skeletally immature (Risser sign 0-3) with a major Cobb angle \\\u003C 40 degrees at baseline.\n5. Written informed consent\u002Fassent provided by the participant and legal guardian.\n\nExclusion Criteria:\n\n1. Unwillingness or inability to comply with all study procedures and follow-up visits.\n2. Plans to relocate outside the study area within the next 24 months.\n3. Previous high-dose vitamin A supplementation therapy within the past 12 months.\n4. Clinical signs of severe vitamin A deficiency syndrome (e.g., xerophthalmia, Bitot's spots).\n5. Serum vitamin A level \\> 0.70 mg\u002FL (to avoid risk of hypervitaminosis A).\n6. Severe chronic health conditions that could confound study outcomes, including but not limited to:\n\n   * Known syndromic, neuromuscular, or congenital musculoskeletal causes of scoliosis.\n   * History of spine surgery or significant spinal trauma.\n   * Spinal tumor.\n   * Leg length discrepancy \\> 20 mm.\n   * Other severe chronic diseases (e.g., poorly controlled diabetes, chronic liver or renal disease, malabsorption syndromes).\n   * Severe obesity (body mass index z-score ≥ 3).","ALL","6 Years","15 Years",{"count":80,"type":81},140,"ESTIMATED","INTERVENTIONAL",[84],"NA","This study aims to investigate whether vitamin A supplementation can influence spinal curve magnitude in idiopathic scoliosis children and potentially prevent its de novo development.",[87,88],"Vitamin A Deficiency","Idiopathic Scoliosis","2026-05-14",{"date":91,"type":92},"2026-05-15","ACTUAL",{"date":94,"type":92},"2025-05-13",{"date":96,"type":81},"2028-06-01",{"name":5,"class":6},1]