[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100599523":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":25,"locations":32,"responsibleParty":51,"collaborators":19,"id":54,"slug":55,"hasResults":56,"nctId":57,"briefTitle":58,"officialTitle":58,"acronym":19,"eligibilityCriteria":59,"healthyVolunteers":56,"sex":60,"minAge":61,"maxAge":62,"enrollmentInfo":63,"targetDuration":19,"studyType":66,"phases":67,"briefSummary":69,"conditions":70,"keywords":72,"overallStatus":34,"whyStopped":19,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"Bangladesh Medical University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"15 male epileptic patients with hypovitaminosis D","EXPERIMENTAL","15 male epileptic patients with hypovitaminosis D will be enrolled. They will be supplemented with Vitamin D orally 50,000 IU\u002Fweek for 8 weeks",[13],"Dietary Supplement: Vitamin D",[15],{"type":16,"name":17,"description":11,"armGroupLabels":18,"otherNames":19},"DIETARY_SUPPLEMENT","Vitamin D",[9],null,[21],{"name":22,"affiliation":23,"role":24},"Dr. Samikha Sarker, MBBS, MD Resident (Phase B)","BMU","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":30,"email":31},"Registrar, BMU","CONTACT","+88 02 55165708","94","registrar@bsmmu.edu.bd",[33],{"facility":5,"status":34,"city":35,"state":36,"zip":37,"country":38,"countryCode":39,"cosmosGeoPoint":40,"geoPoint":45,"contacts":46},"RECRUITING","Dhaka","Shahbag","1000","Bangladesh","BD",{"type":41,"coordinates":42},"Point",[43,44],90.40744,23.7104,{"lat":44,"lon":43},[47,50],{"name":22,"role":28,"phone":48,"phoneExt":19,"email":49},"+88 01774441584","samiksha.damc@gmail.com",{"name":22,"role":24,"phone":19,"phoneExt":19,"email":19},{"type":24,"investigatorFullName":52,"investigatorTitle":53,"investigatorAffiliation":5,"oldNameTitle":19,"oldOrganization":19},"Samikha Sarker","Principal Investigator","100599523","effect-of-vitamin-d3-supplementation-on-cardiac-autonomic-nerve-function-in-male-epileptic-patients-with-hypovitaminosis-d-100599523",false,"NCT07085598","Effect of Vitamin D3 Supplementation on Cardiac Autonomic Nerve Function in Male Epileptic Patients With Hypovitaminosis D","Inclusion Criteria:\n\n* • Diagnosed male patients with Epilepsy by neurologist from the OPD of Department of Neurology by taking proper history of at least two unprovoked (or reflex) seizures occuring \\> 24 hours apart, from patients and eye witnesses.\n\n  * Having hypovitaminosis D (serum vitamin D3 level \\\u003C30 ng\u002Fml)\n  * Age: 20-40 years.\n\n    * Sex: Male\n    * BMI : 18.5-24.9 kg\u002Fm2\n    * Taking antiepileptic drug for 6 months to 2 years ( Enzyme inducer AEDs, e.g. Carbamazepine, Phenytoin, Phenobarbital)\n    * Without medication that affect central nervous system other than antiepileptic drugs (AEDs).\n\nExclusion Criteria:\n\n* • Epileptic patients taking Sodium valproate, oxcarbazepine, Topiramate, Lamotrigine, Levetiracetam.\n\n  * Patient having absence seizure\n  * Alcoholic\n  * Smoker\n  * Patients taking following drugs will be excluded-\n\n    * Anti-diabetic drugs\n    * Antioxidant vitamin supplements\n    * Antihypertensive drug\n    * Anti-arrhythmic drug\n    * Lipid lowering medications\n    * Sedatives\n  * Patients having known hypersensitivity to vitamin D3\n  * All patients with the history of or currently suffering from following diseases \\& condition will be excluded-\n\n    * Cardiovascular disorders (Myocardial infarction, coronary heart disease, cardiac arrhythmia, CCF)\n    * Other neurological disorders (Migraine, stroke)\n    * Respiratory disorders (Bronchial asthma, COPD)\n    * Renal insufficiency (S. Creatinine \\> 1.5 mg\u002Fdl, Acute or chronic kidney disease)\n    * Endocrine disease (Diabetes mellitus, Thyroid disorders- hypothyroidism, hyperthyroidism)\n    * Arthritis (rheumatoid arthritis)\n    * Liver diseases\n    * Neoplastic disease\n    * Psychiatric disorder (schizophrenia, bipolar disorder)\n    * Current use of iron, zinc, calcium, magnesium and multivitamin supplementation\n    * Already performing yoga or breathing exercise\n    * Patients with hypercalcemia","MALE","20 Years","40 Years",{"count":64,"type":65},15,"ESTIMATED","INTERVENTIONAL",[68],"NA","The goal of this clinical trial is to see the effect of vitamin D3 supplementation on cardiac autonomic nerve function in male epileptic patients with hypovitaminosis D that weather vitamin D improves heart rate variability or not. The main questions it aims to answer are:\n\n1. Does vitamin D improves cardiac autonomic tone in male epileptic patients?\n2. Does vitamin D improves heart rate variability in male epileptic patients?\n\nIt is a self control trial. Participants will:\n\n1. undergo through baseline HRV testing\n2. start to take vitamin D3 50000 IU once in a week for 8 weeks\n\nb) visit the university after 8 weeks for post interventional HRV testing . Researcher will compare the pre test and post test value of HRV testing.",[71],"Epilepsy",[73,74,75],"Vitamin D3","Hypovitaminosis D","HRV","2025-07-24",{"date":78,"type":79},"2025-07-25","ACTUAL",{"date":81,"type":65},"2025-07",{"date":83,"type":65},"2025-10",{"name":5,"class":6},1]