[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100561288":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":36,"centralContacts":40,"locations":49,"responsibleParty":79,"collaborators":44,"id":82,"slug":83,"hasResults":84,"nctId":85,"briefTitle":86,"officialTitle":87,"acronym":44,"eligibilityCriteria":88,"healthyVolunteers":84,"sex":89,"minAge":90,"maxAge":91,"enrollmentInfo":92,"targetDuration":44,"studyType":95,"phases":96,"briefSummary":98,"conditions":99,"keywords":102,"overallStatus":52,"whyStopped":44,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"Florida State University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Watermelon Condition","EXPERIMENTAL","This group will maintain a normal diet supplemented with 2.5 cups (\\~375 grams, 115 kcals, 0.5g fat, 1.5g fiber, 17,225mcg lycopene, 30.75mg vitamin C) of fresh watermelon daily for six weeks",[13],"Other: Watermelon",{"label":15,"type":16,"description":17,"interventionNames":18},"Control Condition","ACTIVE_COMPARATOR","This group will maintain a normal diet supplemented with an isocaloric control snack (Belvita breakfast sandwich; 115 kcals, 1.5g fiber, 4.5g fat, 0mg lycopene, 0mg vitamin C) as well as 12 ounces of water",[19],"Other: Belvita Breakfast Sandwich + 12 oz Water",[21,28],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Watermelon","2.5 cups of whole fresh watermelon (\\~375 grams, 115 kcals, 0.5g fat, 1.5g fiber, 17,225mcg lycopene, 30.75mg vitamin C) of fresh watermelon daily for six weeks",[9],[26,27],"Whole Watermelon","Diced Watermelon",{"type":6,"name":29,"description":30,"armGroupLabels":31,"otherNames":32},"Belvita Breakfast Sandwich + 12 oz Water","Belvita breakfast sandwich; 115 kcals, 1.5g fiber, 4.5g fat, 0mg lycopene, 0mg vitamin C) as well as 12 ounces of water",[15],[33,34,35],"Isocaloric Snack","Breakfast Sandwich","Control Snack",[37],{"name":38,"affiliation":5,"role":39},"Ravinder Nagpal, PhD","PRINCIPAL_INVESTIGATOR",[41,46],{"name":38,"role":42,"phone":43,"phoneExt":44,"email":45},"CONTACT","850-644-1829",null,"rnagpal@fsu.edu",{"name":47,"role":42,"phone":44,"phoneExt":44,"email":48},"Cole Patoine, M.S","cjp23a@fsu.edu",[50],{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":56,"countryCode":57,"cosmosGeoPoint":58,"geoPoint":63,"contacts":64},"Florida State University - Gut Biome Lab","RECRUITING","Tallahassee","Florida","32306","United States","US",{"type":59,"coordinates":60},"Point",[61,62],-84.28073,30.43826,{"lat":62,"lon":61},[65,69,70,73,75,77],{"name":66,"role":42,"phone":67,"phoneExt":44,"email":68},"Jania Kadar","+1-850-644-1828","thegutbiomelab@fsu.edu",{"name":38,"role":39,"phone":44,"phoneExt":44,"email":44},{"name":71,"role":72,"phone":44,"phoneExt":44,"email":44},"Cole Patoine, MS","SUB_INVESTIGATOR",{"name":74,"role":72,"phone":44,"phoneExt":44,"email":44},"Saiful Singar, MS",{"name":76,"role":72,"phone":44,"phoneExt":44,"email":44},"Andrea Lobene, PhD",{"name":78,"role":72,"phone":44,"phoneExt":44,"email":44},"Joseph Watso, PhD",{"type":39,"investigatorFullName":80,"investigatorTitle":81,"investigatorAffiliation":5,"oldNameTitle":44,"oldOrganization":44},"Ravi Nagpal","PI","100561288","effect-of-watermelon-on-gut-and-cardiometabolic-health-100561288",false,"NCT06588218","Effect of Watermelon on Gut and Cardiometabolic Health","Effect of Daily Fresh Watermelon Consumption on Gut and Cardiometabolic Health in Young Adults With Overweight and Obesity","Inclusion Criteria:\n\n* Between 18 and 30 years old\n* Ability to speak and read in English\n* Overweight or Obese Class 1 and 2 (BMI ≥ 25 - 39.9 kg\u002Fm2)\n\nExclusion Criteria:\n\n* Intake of antibiotics in the last 3 months\n* Intake of pre\u002Fpro\u002Fpostbiotics in the last 3 months\n* Current or past (within the last 6 months) user of tobacco, marijuana, or E-cigarette products\n* Cardiovascular disease (will not exclude for hypertension), gastrointestinal disease (ulcerative colitis, celiac, Crohn's disease, diverticulosis, peptic ulcers, small intestinal bacterial overgrowth, short bowel syndrome), neurological (multiple sclerosis, meningitis, recent stroke) or endocrine disorders (uncontrolled thyroid disorders, growth hormone disorders, adrenal gland disorders, uncontrolled diabetes - A1C greater than 9%).\n* Food allergy to study foods\n* Any allergy to melon\n* Any allergy to the isocaloric snack (gluten)\n* Regular consumption of watermelon greater than 2 servings \u002F week\n* Current heavy alcohol use (≥ 15 drinks \u002F week for men, ≥ 8 drinks \u002F week for women\n* Class 3 Obesity (BMI \\> 40 kg\u002Fm2)\n* Current user of Citrulline, Arginine, Nitric Oxide or other supplements known to affect nitric oxide synthesis (beet root juice or any beet supplement, Pycnogenol \u002F Pine bark extract)\n* Known to be currently pregnant (self-disclosed)","ALL","18 Years","30 Years",{"count":93,"type":94},36,"ESTIMATED","INTERVENTIONAL",[97],"NA","The goal of this clinical trial is to evaluate the effect of daily fresh watermelon consumption for 6-weeks on gut health, including microbiome diversity, gut barrier and immune function in young adults with overweight and obesity. The main questions it aims to answer are:\n\n1. Will consuming fresh watermelon daily for 6-weeks will improve intestinal barrier health and increase microbiome diversity such as an increased population of beneficial 'probiotic' bacteria when compared to control participants consuming a low-fat snack?\n2. Will consuming fresh watermelon daily for six-weeks will improve other health measures, including body-composition, blood pressure, blood vessel function, blood lipid profiles, and measures of inflammation, as compared to control participants consuming a low-fat snack for the same time period?",[100,101],"Obesity and Overweight","Dysbiosis",[103,101,104,105,106,22,107,108,109,110],"Gut Microbiome","Diet","Overweight","Obesity","Lycopene","Citrulline","Metagenomic","vascular","2026-04-08",{"date":113,"type":114},"2026-04-09","ACTUAL",{"date":116,"type":114},"2024-10-13",{"date":118,"type":94},"2026-12",{"name":5,"class":6},1]