[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100622146":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":24,"locations":32,"responsibleParty":662,"collaborators":10,"id":664,"slug":665,"hasResults":666,"nctId":667,"briefTitle":668,"officialTitle":669,"acronym":10,"eligibilityCriteria":670,"healthyVolunteers":666,"sex":671,"minAge":672,"maxAge":10,"enrollmentInfo":673,"targetDuration":10,"studyType":676,"phases":10,"briefSummary":677,"conditions":678,"keywords":680,"overallStatus":35,"whyStopped":10,"lastUpdateSubmitDate":681,"lastUpdatePostDateStruct":682,"startDateStruct":685,"completionDateStruct":687,"leadSponsor":689,"locationsCount":690},{"fullName":5,"class":6},"Bristol-Myers Squibb","INDUSTRY",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Group 1",null,"Participants diagnosed with schizophrenia receiving xanomeline and trospium chloride (KarXT)",[13],"Drug: Xanomeline and trospium chloride (KarXT)",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":10},"DRUG","Xanomeline and trospium chloride (KarXT)","According to the product label",[9],[21],{"name":22,"affiliation":5,"role":23},"Bristol Myers Squibb","STUDY_DIRECTOR",[25,30],{"name":26,"role":27,"phone":28,"phoneExt":10,"email":29},"BMS Clinical Trials Contact Center www.BMSClinicalTrials.com","CONTACT","855-907-3286","Clinical.Trials@bms.com",{"name":31,"role":27,"phone":10,"phoneExt":10,"email":10},"First line of the email MUST contain NCT # and Site #.",[33,50,64,73,85,97,109,121,135,148,160,172,184,194,203,212,225,237,250,262,274,287,299,312,324,337,350,363,375,387,399,412,425,438,452,464,478,491,504,517,529,541,553,562,571,580,589,601,613,625,637,649],{"facility":34,"status":35,"city":36,"state":37,"zip":38,"country":39,"countryCode":40,"cosmosGeoPoint":41,"geoPoint":46,"contacts":47},"SanRo Clinical Research Group","RECRUITING","Bryant","Arkansas","72022","United States","US",{"type":42,"coordinates":43},"Point",[44,45],-92.48905,34.59593,{"lat":45,"lon":44},[48],{"name":49,"role":27,"phone":10,"phoneExt":10,"email":10},"Robert Wooten, Site 0009",{"facility":51,"status":52,"city":53,"state":54,"zip":55,"country":39,"countryCode":40,"cosmosGeoPoint":56,"geoPoint":60,"contacts":61},"Local Institution - 0047","NOT_YET_RECRUITING","Anaheim","California","92801",{"type":42,"coordinates":57},[58,59],-117.9145,33.83529,{"lat":59,"lon":58},[62],{"name":63,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0047",{"facility":65,"status":52,"city":53,"state":54,"zip":66,"country":39,"countryCode":40,"cosmosGeoPoint":67,"geoPoint":69,"contacts":70},"Local Institution - 0003","92805",{"type":42,"coordinates":68},[58,59],{"lat":59,"lon":58},[71],{"name":72,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0003",{"facility":74,"status":52,"city":75,"state":54,"zip":76,"country":39,"countryCode":40,"cosmosGeoPoint":77,"geoPoint":81,"contacts":82},"Local Institution - 0039","Chino","91710",{"type":42,"coordinates":78},[79,80],-117.68894,34.01223,{"lat":80,"lon":79},[83],{"name":84,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0039",{"facility":86,"status":52,"city":87,"state":54,"zip":88,"country":39,"countryCode":40,"cosmosGeoPoint":89,"geoPoint":93,"contacts":94},"Local Institution - 0012","La Palma","90623",{"type":42,"coordinates":90},[91,92],-118.04673,33.8464,{"lat":92,"lon":91},[95],{"name":96,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0012",{"facility":98,"status":52,"city":99,"state":54,"zip":100,"country":39,"countryCode":40,"cosmosGeoPoint":101,"geoPoint":105,"contacts":106},"Local Institution - 0043","Oceanside","92056-4509",{"type":42,"coordinates":102},[103,104],-117.37948,33.19587,{"lat":104,"lon":103},[107],{"name":108,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0043",{"facility":110,"status":52,"city":111,"state":54,"zip":112,"country":39,"countryCode":40,"cosmosGeoPoint":113,"geoPoint":117,"contacts":118},"Local Institution - 0028","Stanford","94304",{"type":42,"coordinates":114},[115,116],-122.16608,37.42411,{"lat":116,"lon":115},[119],{"name":120,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0028",{"facility":122,"status":35,"city":123,"state":124,"zip":125,"country":39,"countryCode":40,"cosmosGeoPoint":126,"geoPoint":130,"contacts":131},"Envision Trials LLC","Bonita Springs","Florida","34134",{"type":42,"coordinates":127},[128,129],-81.7787,26.33981,{"lat":129,"lon":128},[132],{"name":133,"role":27,"phone":134,"phoneExt":10,"email":10},"Daniel Mandri, Site 0005","305-819-2909",{"facility":136,"status":35,"city":137,"state":124,"zip":138,"country":39,"countryCode":40,"cosmosGeoPoint":139,"geoPoint":143,"contacts":144},"Galiz Research","Hialeah","33016-1814",{"type":42,"coordinates":140},[141,142],-80.27811,25.8576,{"lat":142,"lon":141},[145],{"name":146,"role":27,"phone":147,"phoneExt":10,"email":10},"Jose Gamez, Site 0019","305-805-0921",{"facility":149,"status":52,"city":150,"state":124,"zip":151,"country":39,"countryCode":40,"cosmosGeoPoint":152,"geoPoint":156,"contacts":157},"Local Institution - 0030","Homestead","33030",{"type":42,"coordinates":153},[154,155],-80.47756,25.46872,{"lat":155,"lon":154},[158],{"name":159,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0030",{"facility":161,"status":35,"city":162,"state":124,"zip":163,"country":39,"countryCode":40,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"New Access Research & Medical Services Inc - Kendall","Kendall","33186",{"type":42,"coordinates":165},[166,167],-80.31727,25.67927,{"lat":167,"lon":166},[170],{"name":171,"role":27,"phone":10,"phoneExt":10,"email":10},"Ana Maria Tous, Site 0029",{"facility":173,"status":52,"city":174,"state":124,"zip":175,"country":39,"countryCode":40,"cosmosGeoPoint":176,"geoPoint":180,"contacts":181},"Local Institution - 0032","Miami","33015",{"type":42,"coordinates":177},[178,179],-80.19366,25.77427,{"lat":179,"lon":178},[182],{"name":183,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0032",{"facility":185,"status":35,"city":174,"state":124,"zip":186,"country":39,"countryCode":40,"cosmosGeoPoint":187,"geoPoint":189,"contacts":190},"Banyan Behavioal Care Program - CSU","33134",{"type":42,"coordinates":188},[178,179],{"lat":179,"lon":178},[191],{"name":192,"role":27,"phone":193,"phoneExt":10,"email":10},"Moraima Trujillo, Site 0011","305-246-0001",{"facility":195,"status":52,"city":174,"state":124,"zip":196,"country":39,"countryCode":40,"cosmosGeoPoint":197,"geoPoint":199,"contacts":200},"Local Institution - 0007","33155",{"type":42,"coordinates":198},[178,179],{"lat":179,"lon":178},[201],{"name":202,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0007",{"facility":204,"status":35,"city":174,"state":124,"zip":205,"country":39,"countryCode":40,"cosmosGeoPoint":206,"geoPoint":208,"contacts":209},"BioResearch Partner - Miami","33175",{"type":42,"coordinates":207},[178,179],{"lat":179,"lon":178},[210],{"name":211,"role":27,"phone":10,"phoneExt":10,"email":10},"Fenton Lebon, Site 0006",{"facility":213,"status":35,"city":214,"state":124,"zip":215,"country":39,"countryCode":40,"cosmosGeoPoint":216,"geoPoint":220,"contacts":221},"Medical Research of Central Florida","Orange City","32763",{"type":42,"coordinates":217},[218,219],-81.29867,28.94888,{"lat":219,"lon":218},[222],{"name":223,"role":27,"phone":224,"phoneExt":10,"email":10},"Adly Thebaud, Site 0023","386-775-7627",{"facility":226,"status":52,"city":227,"state":124,"zip":228,"country":39,"countryCode":40,"cosmosGeoPoint":229,"geoPoint":233,"contacts":234},"Local Institution - 0040","Orlando","32803",{"type":42,"coordinates":230},[231,232],-81.37924,28.53834,{"lat":232,"lon":231},[235],{"name":236,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0040",{"facility":238,"status":52,"city":239,"state":240,"zip":241,"country":39,"countryCode":40,"cosmosGeoPoint":242,"geoPoint":246,"contacts":247},"Local Institution - 0025","Atlanta","Georgia","30303",{"type":42,"coordinates":243},[244,245],-84.38798,33.749,{"lat":245,"lon":244},[248],{"name":249,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0025",{"facility":251,"status":52,"city":252,"state":240,"zip":253,"country":39,"countryCode":40,"cosmosGeoPoint":254,"geoPoint":258,"contacts":259},"Local Institution - 0049","Austell","30106",{"type":42,"coordinates":255},[256,257],-84.63438,33.81261,{"lat":257,"lon":256},[260],{"name":261,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0049",{"facility":263,"status":52,"city":264,"state":240,"zip":265,"country":39,"countryCode":40,"cosmosGeoPoint":266,"geoPoint":270,"contacts":271},"Local Institution - 0044","Marietta","30060",{"type":42,"coordinates":267},[268,269],-84.54993,33.9526,{"lat":269,"lon":268},[272],{"name":273,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0044",{"facility":275,"status":52,"city":276,"state":277,"zip":278,"country":39,"countryCode":40,"cosmosGeoPoint":279,"geoPoint":283,"contacts":284},"Local Institution - 0046","Crystal Lake","Illinois","60523",{"type":42,"coordinates":280},[281,282],-88.3162,42.24113,{"lat":282,"lon":281},[285],{"name":286,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0046",{"facility":288,"status":52,"city":289,"state":277,"zip":290,"country":39,"countryCode":40,"cosmosGeoPoint":291,"geoPoint":295,"contacts":296},"Local Institution - 0048","Warrenville","60555",{"type":42,"coordinates":292},[293,294],-88.1734,41.81781,{"lat":294,"lon":293},[297],{"name":298,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0048",{"facility":300,"status":52,"city":301,"state":302,"zip":303,"country":39,"countryCode":40,"cosmosGeoPoint":304,"geoPoint":308,"contacts":309},"Local Institution - 0014","Bloomfield Township","Michigan","48302-1909",{"type":42,"coordinates":305},[306,307],-83.27342,42.5756,{"lat":307,"lon":306},[310],{"name":311,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0014",{"facility":313,"status":52,"city":314,"state":302,"zip":315,"country":39,"countryCode":40,"cosmosGeoPoint":316,"geoPoint":320,"contacts":321},"Local Institution - 0036","Detroit","48203",{"type":42,"coordinates":317},[318,319],-83.04575,42.33143,{"lat":319,"lon":318},[322],{"name":323,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0036",{"facility":325,"status":52,"city":326,"state":327,"zip":328,"country":39,"countryCode":40,"cosmosGeoPoint":329,"geoPoint":333,"contacts":334},"Local Institution - 0034","Apple Valley","Minnesota","55124",{"type":42,"coordinates":330},[331,332],-93.21772,44.73191,{"lat":332,"lon":331},[335],{"name":336,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0034",{"facility":338,"status":52,"city":339,"state":340,"zip":341,"country":39,"countryCode":40,"cosmosGeoPoint":342,"geoPoint":346,"contacts":347},"Local Institution - 0041","Lincoln","Nebraska","68526-9474",{"type":42,"coordinates":343},[344,345],-96.66696,40.8,{"lat":345,"lon":344},[348],{"name":349,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0041",{"facility":351,"status":52,"city":352,"state":353,"zip":354,"country":39,"countryCode":40,"cosmosGeoPoint":355,"geoPoint":359,"contacts":360},"Local Institution - 0037","Buffalo","New York","14215",{"type":42,"coordinates":356},[357,358],-78.87837,42.88645,{"lat":358,"lon":357},[361],{"name":362,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0037",{"facility":364,"status":52,"city":365,"state":353,"zip":366,"country":39,"countryCode":40,"cosmosGeoPoint":367,"geoPoint":371,"contacts":372},"Local Institution - 0004","Monsey","10952",{"type":42,"coordinates":368},[369,370],-74.06848,41.11121,{"lat":370,"lon":369},[373],{"name":374,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0004",{"facility":376,"status":52,"city":377,"state":353,"zip":378,"country":39,"countryCode":40,"cosmosGeoPoint":379,"geoPoint":383,"contacts":384},"Local Institution - 0038","Rochester","14623",{"type":42,"coordinates":380},[381,382],-77.61556,43.15478,{"lat":382,"lon":381},[385],{"name":386,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0038",{"facility":388,"status":52,"city":389,"state":353,"zip":390,"country":39,"countryCode":40,"cosmosGeoPoint":391,"geoPoint":395,"contacts":396},"Local Institution - 0020","White Plains","10601",{"type":42,"coordinates":392},[393,394],-73.76291,41.03399,{"lat":394,"lon":393},[397],{"name":398,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0020",{"facility":400,"status":52,"city":401,"state":402,"zip":403,"country":39,"countryCode":40,"cosmosGeoPoint":404,"geoPoint":408,"contacts":409},"Local Institution - 0042","Cary","North Carolina","27513",{"type":42,"coordinates":405},[406,407],-78.78112,35.79154,{"lat":407,"lon":406},[410],{"name":411,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0042",{"facility":413,"status":35,"city":414,"state":402,"zip":415,"country":39,"countryCode":40,"cosmosGeoPoint":416,"geoPoint":420,"contacts":421},"PPD Virtual - PPD - US","Wilmington","28401-3331",{"type":42,"coordinates":417},[418,419],-77.94604,34.23556,{"lat":419,"lon":418},[422],{"name":423,"role":27,"phone":424,"phoneExt":10,"email":10},"Ghazaleh Bahrami, Site 0001","866-609-3139",{"facility":426,"status":52,"city":427,"state":428,"zip":429,"country":39,"countryCode":40,"cosmosGeoPoint":430,"geoPoint":434,"contacts":435},"Local Institution - 0031","Mason","Ohio","45040-7846",{"type":42,"coordinates":431},[432,433],-84.30994,39.36006,{"lat":433,"lon":432},[436],{"name":437,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0031",{"facility":439,"status":35,"city":440,"state":441,"zip":442,"country":39,"countryCode":40,"cosmosGeoPoint":443,"geoPoint":447,"contacts":448},"The Rivus Wellness & Research Institute","Oklahoma City","Oklahoma","73112-8729",{"type":42,"coordinates":444},[445,446],-97.51643,35.46756,{"lat":446,"lon":445},[449],{"name":450,"role":27,"phone":451,"phoneExt":10,"email":10},"Marvin Peyton, Site 0027","405-317-5783",{"facility":453,"status":52,"city":454,"state":441,"zip":455,"country":39,"countryCode":40,"cosmosGeoPoint":456,"geoPoint":460,"contacts":461},"Local Institution - 0052","Tulsa","74135",{"type":42,"coordinates":457},[458,459],-95.99277,36.15398,{"lat":459,"lon":458},[462],{"name":463,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0052",{"facility":465,"status":35,"city":466,"state":467,"zip":468,"country":39,"countryCode":40,"cosmosGeoPoint":469,"geoPoint":473,"contacts":474},"Perelman School of Medicine at the University of Pennsylvania","Philadelphia","Pennsylvania","19104-4238",{"type":42,"coordinates":470},[471,472],-75.16362,39.95238,{"lat":472,"lon":471},[475],{"name":476,"role":27,"phone":477,"phoneExt":10,"email":10},"Raquel Gur, Site 0015","215-662-2915",{"facility":479,"status":52,"city":480,"state":481,"zip":482,"country":39,"countryCode":40,"cosmosGeoPoint":483,"geoPoint":487,"contacts":488},"Local Institution - 0051","Cordova","Tennessee","38018",{"type":42,"coordinates":484},[485,486],-89.7762,35.15565,{"lat":486,"lon":485},[489],{"name":490,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0051",{"facility":492,"status":35,"city":493,"state":481,"zip":494,"country":39,"countryCode":40,"cosmosGeoPoint":495,"geoPoint":499,"contacts":500},"Psychiatric Consultants, Pc","Franklin","37607",{"type":42,"coordinates":496},[497,498],-86.86889,35.92506,{"lat":498,"lon":497},[501],{"name":502,"role":27,"phone":503,"phoneExt":10,"email":10},"James Hart, Site 0002","615-807-4025",{"facility":505,"status":52,"city":506,"state":507,"zip":508,"country":39,"countryCode":40,"cosmosGeoPoint":509,"geoPoint":513,"contacts":514},"Local Institution - 0016","Austin","Texas","78754",{"type":42,"coordinates":510},[511,512],-97.74306,30.26715,{"lat":512,"lon":511},[515],{"name":516,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0016",{"facility":518,"status":52,"city":519,"state":507,"zip":520,"country":39,"countryCode":40,"cosmosGeoPoint":521,"geoPoint":525,"contacts":526},"Local Institution - 0050","Dallas","75390",{"type":42,"coordinates":522},[523,524],-96.80667,32.78306,{"lat":524,"lon":523},[527],{"name":528,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0050",{"facility":530,"status":52,"city":531,"state":507,"zip":532,"country":39,"countryCode":40,"cosmosGeoPoint":533,"geoPoint":537,"contacts":538},"Local Institution - 0021","Fort Worth","76132",{"type":42,"coordinates":534},[535,536],-97.32085,32.72541,{"lat":536,"lon":535},[539],{"name":540,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0021",{"facility":542,"status":52,"city":543,"state":507,"zip":544,"country":39,"countryCode":40,"cosmosGeoPoint":545,"geoPoint":549,"contacts":550},"Local Institution - 0033","Houston","77007-9015",{"type":42,"coordinates":546},[547,548],-95.36327,29.76328,{"lat":548,"lon":547},[551],{"name":552,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0033",{"facility":554,"status":52,"city":543,"state":507,"zip":555,"country":39,"countryCode":40,"cosmosGeoPoint":556,"geoPoint":558,"contacts":559},"Local Institution - 0026","77008-1758",{"type":42,"coordinates":557},[547,548],{"lat":548,"lon":547},[560],{"name":561,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0026",{"facility":563,"status":52,"city":543,"state":507,"zip":564,"country":39,"countryCode":40,"cosmosGeoPoint":565,"geoPoint":567,"contacts":568},"Local Institution - 0022","77054-2852",{"type":42,"coordinates":566},[547,548],{"lat":548,"lon":547},[569],{"name":570,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0022",{"facility":572,"status":52,"city":543,"state":507,"zip":573,"country":39,"countryCode":40,"cosmosGeoPoint":574,"geoPoint":576,"contacts":577},"Local Institution - 0010","77054",{"type":42,"coordinates":575},[547,548],{"lat":548,"lon":547},[578],{"name":579,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0010",{"facility":581,"status":35,"city":543,"state":507,"zip":582,"country":39,"countryCode":40,"cosmosGeoPoint":583,"geoPoint":585,"contacts":586},"Pioneer Research Solutions, Inc.","77099",{"type":42,"coordinates":584},[547,548],{"lat":548,"lon":547},[587],{"name":588,"role":27,"phone":10,"phoneExt":10,"email":10},"Ateka Zaki, Site 0024",{"facility":590,"status":52,"city":591,"state":507,"zip":592,"country":39,"countryCode":40,"cosmosGeoPoint":593,"geoPoint":597,"contacts":598},"Local Institution - 0017","Irving","75062-2757",{"type":42,"coordinates":594},[595,596],-96.94889,32.81402,{"lat":596,"lon":595},[599],{"name":600,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0017",{"facility":602,"status":52,"city":603,"state":507,"zip":604,"country":39,"countryCode":40,"cosmosGeoPoint":605,"geoPoint":609,"contacts":610},"Local Institution - 0013","McKinney","75092",{"type":42,"coordinates":606},[607,608],-96.61527,33.19762,{"lat":608,"lon":607},[611],{"name":612,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0013",{"facility":614,"status":35,"city":615,"state":507,"zip":616,"country":39,"countryCode":40,"cosmosGeoPoint":617,"geoPoint":621,"contacts":622},"Perceptive Pharma Research","Richmond","77407-3498",{"type":42,"coordinates":618},[619,620],-95.76078,29.58218,{"lat":620,"lon":619},[623],{"name":624,"role":27,"phone":10,"phoneExt":10,"email":10},"Adeeb Masood, Site 0008",{"facility":626,"status":52,"city":627,"state":507,"zip":628,"country":39,"countryCode":40,"cosmosGeoPoint":629,"geoPoint":633,"contacts":634},"Local Institution - 0035","San Antonio","78240",{"type":42,"coordinates":630},[631,632],-98.49363,29.42412,{"lat":632,"lon":631},[635],{"name":636,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0035",{"facility":638,"status":52,"city":639,"state":507,"zip":640,"country":39,"countryCode":40,"cosmosGeoPoint":641,"geoPoint":645,"contacts":646},"Local Institution - 0018","Stafford","77477-3954",{"type":42,"coordinates":642},[643,644],-95.55772,29.61607,{"lat":644,"lon":643},[647],{"name":648,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0018",{"facility":650,"status":52,"city":651,"state":652,"zip":653,"country":39,"countryCode":40,"cosmosGeoPoint":654,"geoPoint":658,"contacts":659},"Local Institution - 0045","Petersburg","Virginia","23805",{"type":42,"coordinates":655},[656,657],-77.40193,37.22793,{"lat":657,"lon":656},[660],{"name":661,"role":27,"phone":10,"phoneExt":10,"email":10},"Site 0045",{"type":663,"investigatorFullName":10,"investigatorTitle":10,"investigatorAffiliation":10,"oldNameTitle":10,"oldOrganization":10},"SPONSOR","100622146","effectiveness-and-adverse-effect-switch-evaluation-of-xanomeline-and-trospium-chloride-karxt-100622146",false,"NCT07379827","Effectiveness and Adverse-effect Switch Evaluation of Xanomeline and Trospium Chloride (KarXT)","Effectiveness and Adverse-effect Switch Evaluation","Inclusion Criteria:\n\n* Participants (or caregiver\u002Flegal guardian) must have signed and dated an Institutional Review Board (IRB)\u002FIndependent Ethics Committee (IEC)-approved written ICF or signed an electronic ICF in accordance with regulatory, local, and institutional guidelines.\n* Adults ≥ 18 years of age at Baseline who are willing and able, in the judgement of the treating clinician, to participate in routine clinical care and follow up.\n* Schizophrenia, confirmed by the treating clinician's judgement or physician decision to treat the patient with receiving xanomeline and trospium chloride (KarXT) for schizophrenia made prior to and independently of participation in this study. Current Antipsychotic Treatment: Participant must fall into one of the categories below:\n\n  * Be within \\\u003C16 weeks of initiating treatment with KarXT with intent to discontinue prior antipsychotic treatment(s) OR\n  * On a stable regimen (dose and frequency consistent with the drug label and\u002For at a stable dose based on the judgement of the Investigator for at least 30 days prior to screening) of treatment with 1 or more antipsychotics with plan to discontinue and switch to treatment with KarXT from a prior antipsychotic treatments(s). NOTE: The decision to switch for reasons of safety, tolerability, and\u002For efficacy will be made independently by the treating clinician and\u002For the patient and is not dictated by the study. Participants can be enrolled during tapering\u002Fdiscontinuing process from prior antipsychotic treatment(s). Individuals who are not currently receiving treatment for schizophrenia are not eligible for the study. Any antipsychotic treatments must be recorded as concomitant medications.\n* Concomitant psychiatric medications (eg, antidepressants, mood stabilizers, anxiolytics) are permitted and are recommended to remain at a stable dose during the study period.\n\nExclusion Criteria:\n\n* Prior use of KarXT that has been discontinued for any reason prior to Baseline.\n* Participation in an interventional study within the last 30 days or plans to participate in an interventional study at the time of eligibility or baseline through the study period.\n* Known hypersensitivity to xanomeline or trospium chloride, or history or high risk of urinary retention, gastric retention, moderate (Child-Pugh Class B) or severe (Child-Pugh Class C) hepatic impairment, or narrow-angle glaucoma.\n* In the opinion of the treating clinician, unstable psychiatric or medical conditions that would prevent the participant from safely switching to KarXT. Hospitalized individuals who have been switched to KarXT or are switching treatment to KarXT are permitted to be enrolled at discharge if they are \\\u003C 16 weeks from initiation of KarXT.\n* Participants who are pregnant, planning to become pregnant, or breastfeeding.","ALL","18 Years",{"count":674,"type":675},1500,"ESTIMATED","OBSERVATIONAL","The purpose of this study is to describe real-world treatment patterns, effectiveness and adverse events of adults diagnosed with schizophrenia that have initiated xanomeline and trospium chloride (KarXT) treatment in the United States",[679],"Schizophrenia",[679],"2026-06-17",{"date":683,"type":684},"2026-06-18","ACTUAL",{"date":686,"type":684},"2026-02-26",{"date":688,"type":675},"2028-06-20",{"name":5,"class":6},52]