[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100635482":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":20,"centralContacts":21,"locations":27,"responsibleParty":41,"collaborators":20,"id":43,"slug":44,"hasResults":45,"nctId":46,"briefTitle":47,"officialTitle":48,"acronym":20,"eligibilityCriteria":49,"healthyVolunteers":45,"sex":50,"minAge":51,"maxAge":20,"enrollmentInfo":52,"targetDuration":20,"studyType":55,"phases":56,"briefSummary":58,"conditions":59,"keywords":63,"overallStatus":75,"whyStopped":20,"lastUpdateSubmitDate":76,"lastUpdatePostDateStruct":77,"startDateStruct":80,"completionDateStruct":82,"leadSponsor":84,"locationsCount":85},{"fullName":5,"class":6},"King Hussein Cancer Center","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"Standard Care plus Normal Saline Soaks (Intervention Group)","EXPERIMENTAL","Participants in this arm will receive standard care in addition to daily normal saline soaks. The intervention consists of applying sterile gauze soaked in room-temperature 0.9% sodium chloride solution to the irradiated skin area for 5-10 minutes once daily. Participants will be trained in clinic and will continue home application throughout the radiotherapy course under routine follow-up.",[13],"Other: Normal Saline Soaks (0.9% Sodium Chloride)",[15],{"type":6,"name":16,"description":11,"armGroupLabels":17,"otherNames":18},"Normal Saline Soaks (0.9% Sodium Chloride)",[9],[19],"0.9% Sodium Chloride Solution Soaks",null,[22],{"name":23,"role":24,"phone":25,"phoneExt":20,"email":26},"Muna Al Sayed, BSN","CONTACT","+962 7 97775542","MA.07855@KHCC.JO",[28],{"facility":29,"status":20,"city":30,"state":31,"zip":32,"country":33,"countryCode":34,"cosmosGeoPoint":35,"geoPoint":40,"contacts":20},"King Hussien Cancer Center","Amman","Al-Jubeiha","11941","Jordan","JO",{"type":36,"coordinates":37},"Point",[38,39],35.94503,31.95522,{"lat":39,"lon":38},{"type":42,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100635482","effectiveness-of-09-normal-saline-soaking-in-managing-acute-radiation-dermatitis-100635482",false,"NCT07553260","Effectiveness of 0.9% Normal Saline Soaking in Managing Acute Radiation Dermatitis","The Effectiveness of Saline Soaks in Managing Acute Radiation Dermatitis","Inclusion Criteria:\n\n* Age ≥ 18 years\n* Eastern Cooperative Oncology Group (ECOG) performance status 0-1\n* Patients receiving definitive radiotherapy for sarcomas or head and neck cancer (primary or postoperative treatment)\n* Planned radiation dose between 60-70 Gy according to disease-specific protocols\n* No prior history of malignancy other than sarcomas\n* Ability and willingness to comply with study procedures (\\>90% expected adherence)\n* Signed informed consent\n\nExclusion Criteria:\n\n* Patients receiving palliative radiotherapy\n* Known pre-existing skin disorders affecting radiation area (e.g., systemic lupus erythematosus, scleroderma)\n* ECOG performance status ≥2\n* Previous radiotherapy to the same treatment field\n* Any condition that, in the investigator's judgment, may interfere with participation or wound healing assessment","ALL","18 Years",{"count":53,"type":54},150,"ESTIMATED","INTERVENTIONAL",[57],"NA","The goal of this clinical trial is to learn if normal saline soaks can reduce the severity of acute radiation dermatitis in patients with sarcomas or head and neck cancer receiving radiotherapy. It will also learn if saline soaks can improve wound healing and reduce treatment interruptions caused by skin toxicity. The main questions it aims to answer are:\n\n1. Does the application of normal saline soaks reduce the severity of acute radiation dermatitis according to CTCAE Version 5.0?\n2. Does the use of normal saline soaks improve wound healing time and reduce the frequency and duration of radiotherapy interruptions? Researchers will compare standard care plus saline soaks (intervention group) to standard care alone (control group) to see if saline soaks reduce skin reaction severity and improve clinical outcomes.\n\nParticipants will:\n\n1. Be randomly assigned to receive either standard care alone or standard care with daily saline soaks\n2. Apply saline-soaked gauze to the affected radiation area for 5-10 minutes once daily (intervention group only)\n3. Attend weekly clinic visits for skin assessment during radiotherapy\n4. Be assessed for skin reaction severity, wound healing, and treatment interruptions at baseline, after 4 weeks, and 2 weeks after completing treatment",[60,61,62],"Acute Radiation Dermatitis","Head and Neck Cancer (H&N)","Sarcomas",[64,65,66,67,68,69,70,71,72,73,74],"Dermatitis, Radiation-Induced","Skin Diseases, Radiation-Induced","Radiotherapy","Head and Neck Neoplasms","Sarcoma","Sodium Chloride","Wound Healing","Skin Care","Moist Desquamation","Supportive Care","Treatment Outcome","NOT_YET_RECRUITING","2026-04-20",{"date":78,"type":79},"2026-04-27","ACTUAL",{"date":81,"type":54},"2026-05",{"date":83,"type":54},"2027-06",{"name":5,"class":6},1]