[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100595367":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":259,"collaborators":26,"id":261,"slug":262,"hasResults":263,"nctId":264,"briefTitle":265,"officialTitle":266,"acronym":267,"eligibilityCriteria":268,"healthyVolunteers":263,"sex":269,"minAge":270,"maxAge":271,"enrollmentInfo":272,"targetDuration":26,"studyType":275,"phases":276,"briefSummary":278,"conditions":279,"keywords":281,"overallStatus":59,"whyStopped":26,"lastUpdateSubmitDate":287,"lastUpdatePostDateStruct":288,"startDateStruct":291,"completionDateStruct":293,"leadSponsor":295,"locationsCount":296},{"fullName":5,"class":6},"China National Center for Cardiovascular Diseases","OTHER_GOV",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"AI-Enabled Stratified Management Group","EXPERIMENTAL","Participants in the intervention group will use SMART-CHD alongside usual post-discharge care.",[13,14],"Combination Product: AI-Enabled Stratified Management System","Combination Product: Usual Post-Discharge Care",{"label":16,"type":17,"description":18,"interventionNames":19},"Usual Post-Discharge Care Group","ACTIVE_COMPARATOR","Participants in the control group will receive usual discharge protocol comprising verbal and printed discharge instructions addressing medication schedules, follow-up timelines, and lifestyle optimization strategies.",[14],[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"COMBINATION_PRODUCT","AI-Enabled Stratified Management System","After discharge, participants install SMART-CHD, sync their EHR data, and complete a 10-minute orientation. They then use the app's OCR-assisted surveys to report lifestyle, lab, and event data, while paired wearables stream continuous vitals. AI voice calls and a CRC-managed WeChat group deliver reminders and support. The app's embedded predictive models stratify them into risk tiers and generate tier-specific follow-up schedules. Personalized lifestyle modification guidance, dietary plans, and medication adjustment recommendations are generated by the platform's module. Automated alerts and teleconsultation options are triggered upon detection of high-risk signs or abnormal results, ensuring timely clinical intervention and enhanced secondary prevention.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Usual Post-Discharge Care","Usual discharge protocol comprising verbal and printed discharge instructions addressing medication schedules, follow-up timelines, and lifestyle optimization strategies.",[9,16],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Gao Prof. Gao, MD, PhD","CONTACT","010-88322413","sophie_gao@sina.com",[38,57,71,86,101,111,126,140,150,159,174,188,203,214,229,244],{"facility":39,"status":40,"city":41,"state":42,"zip":43,"country":44,"countryCode":45,"cosmosGeoPoint":46,"geoPoint":51,"contacts":52},"The First Affiliated Hospital of University of Science and Technology of China","NOT_YET_RECRUITING","Hefei","Anhui","230001","China","CN",{"type":47,"coordinates":48},"Point",[49,50],117.28083,31.86389,{"lat":50,"lon":49},[53],{"name":54,"role":34,"phone":55,"phoneExt":26,"email":56},"Ke Meng","19995377625","19995377625@163.com",{"facility":58,"status":59,"city":60,"state":61,"zip":62,"country":44,"countryCode":45,"cosmosGeoPoint":63,"geoPoint":67,"contacts":68},"Fuwai Hospital, Chinese Academy of Medical Sciences\u002FNational Center for Cardiovascular Diseases","RECRUITING","Beijing","Beijing Municipality","100037",{"type":47,"coordinates":64},[65,66],116.39723,39.9075,{"lat":66,"lon":65},[69],{"name":33,"role":34,"phone":70,"phoneExt":26,"email":36},"+86 8832 2413",{"facility":72,"status":40,"city":73,"state":74,"zip":75,"country":44,"countryCode":45,"cosmosGeoPoint":76,"geoPoint":80,"contacts":81},"Fuwai Hospital Chinese Academy of Medical Sciences, Shenzhen","Shenzhen","Guangdong","518057",{"type":47,"coordinates":77},[78,79],114.0683,22.54554,{"lat":79,"lon":78},[82],{"name":83,"role":34,"phone":84,"phoneExt":26,"email":85},"Fenghuan Hu, MD","0755-25509566","hufenghuanvip@163.com",{"facility":87,"status":40,"city":88,"state":89,"zip":90,"country":44,"countryCode":45,"cosmosGeoPoint":91,"geoPoint":95,"contacts":96},"The First Hospital of Hebei Medical University","Shijiazhuang","Hebei","050000",{"type":47,"coordinates":92},[93,94],114.47861,38.04139,{"lat":94,"lon":93},[97],{"name":98,"role":34,"phone":99,"phoneExt":26,"email":100},"Fangfang Ma","13932108925","fad@hebmu.edu.cn",{"facility":102,"status":40,"city":88,"state":89,"zip":90,"country":44,"countryCode":45,"cosmosGeoPoint":103,"geoPoint":105,"contacts":106},"The Second Hospital Of Hebe Medical University",{"type":47,"coordinates":104},[93,94],{"lat":94,"lon":93},[107],{"name":108,"role":34,"phone":109,"phoneExt":26,"email":110},"Xinshun Gu","0311-66636037","pub@hb2h.com",{"facility":112,"status":40,"city":113,"state":114,"zip":115,"country":44,"countryCode":45,"cosmosGeoPoint":116,"geoPoint":120,"contacts":121},"The First Affiliated Hospital of Henan University of Science and Technology","Luoyang","Henan","471003",{"type":47,"coordinates":117},[118,119],112.43684,34.67345,{"lat":119,"lon":118},[122],{"name":123,"role":34,"phone":124,"phoneExt":26,"email":125},"Mengjuan Xu","15903076908","zhijuanli66@sina.com",{"facility":127,"status":40,"city":128,"state":114,"zip":129,"country":44,"countryCode":45,"cosmosGeoPoint":130,"geoPoint":134,"contacts":135},"Henan Provincial Chest Hospital","Zhengzhou","450000",{"type":47,"coordinates":131},[132,133],113.64861,34.75778,{"lat":133,"lon":132},[136],{"name":137,"role":34,"phone":138,"phoneExt":26,"email":139},"Zhe Peng","15538128220","15538128220@qq.com",{"facility":141,"status":40,"city":128,"state":114,"zip":129,"country":44,"countryCode":45,"cosmosGeoPoint":142,"geoPoint":144,"contacts":145},"Zhengzhou University Affiliated Zhengzhou Central Hospital",{"type":47,"coordinates":143},[132,133],{"lat":133,"lon":132},[146],{"name":147,"role":34,"phone":148,"phoneExt":26,"email":149},"Xiaojie Yang","18631423366","18631423366@163.com",{"facility":151,"status":40,"city":128,"state":114,"zip":129,"country":44,"countryCode":45,"cosmosGeoPoint":152,"geoPoint":154,"contacts":155},"Zhengzhou University Fuwai Central China Cardiovascular Hospital",{"type":47,"coordinates":153},[132,133],{"lat":133,"lon":132},[156],{"name":157,"role":34,"phone":99,"phoneExt":26,"email":158},"You Zhang","gaocy6802@163.com",{"facility":160,"status":40,"city":161,"state":162,"zip":163,"country":44,"countryCode":45,"cosmosGeoPoint":164,"geoPoint":168,"contacts":169},"The First Affiliated Hospital of Nanjing Medical University","Nanjing","Jiangsu","210029",{"type":47,"coordinates":165},[166,167],118.77778,32.06167,{"lat":167,"lon":166},[170],{"name":171,"role":34,"phone":172,"phoneExt":26,"email":173},"Jiabao Liu, MD","025-68303127","jiabaoliu@njmu.edu.cn",{"facility":175,"status":40,"city":176,"state":162,"zip":177,"country":44,"countryCode":45,"cosmosGeoPoint":178,"geoPoint":182,"contacts":183},"Northern Jiangsu People's Hospital","Yangzhou","225001",{"type":47,"coordinates":179},[180,181],119.43583,32.39722,{"lat":181,"lon":180},[184],{"name":185,"role":34,"phone":186,"phoneExt":26,"email":187},"Jing Yang","18512178336","nyxb1980@163.com",{"facility":189,"status":40,"city":190,"state":191,"zip":192,"country":44,"countryCode":45,"cosmosGeoPoint":193,"geoPoint":197,"contacts":198},"The Second Affiliated Hospital of Xi'an Jiaotong University","Xi'an","Shaanxi","710004",{"type":47,"coordinates":194},[195,196],108.92861,34.25833,{"lat":196,"lon":195},[199],{"name":200,"role":34,"phone":201,"phoneExt":26,"email":202},"Jie Liu","029-87679000","eyshce@126.com",{"facility":204,"status":40,"city":190,"state":191,"zip":205,"country":44,"countryCode":45,"cosmosGeoPoint":206,"geoPoint":208,"contacts":209},"The First Affiliated Hospital of Xi'an Jiaotong University","710061",{"type":47,"coordinates":207},[195,196],{"lat":196,"lon":195},[210],{"name":211,"role":34,"phone":212,"phoneExt":26,"email":213},"Huan Wu, MD","029-85323211","1279952786@qq.com",{"facility":215,"status":40,"city":216,"state":217,"zip":218,"country":44,"countryCode":45,"cosmosGeoPoint":219,"geoPoint":223,"contacts":224},"Shanxi Cardiovascular Disease Hospital","Taiyuan","Shanxi","030024",{"type":47,"coordinates":220},[221,222],112.56028,37.86944,{"lat":222,"lon":221},[225],{"name":226,"role":34,"phone":227,"phoneExt":26,"email":228},"Jingyi Liu","18235123471","18235123471@163.com",{"facility":230,"status":40,"city":231,"state":232,"zip":233,"country":44,"countryCode":45,"cosmosGeoPoint":234,"geoPoint":238,"contacts":239},"The Affiliated Hospital of Southwest Medical University","Luzhou","Sichuan","400042",{"type":47,"coordinates":235},[236,237],105.42575,28.8903,{"lat":237,"lon":236},[240],{"name":241,"role":34,"phone":242,"phoneExt":26,"email":243},"Ling Wu, MD","0830-3165101","wulingzt@163.com",{"facility":245,"status":40,"city":246,"state":247,"zip":248,"country":44,"countryCode":45,"cosmosGeoPoint":249,"geoPoint":253,"contacts":254},"The Second Affiliated Hospital, School of Medicine, Zhejiang University","Hangzhou","Zhejiang","310009",{"type":47,"coordinates":250},[251,252],120.16142,30.29365,{"lat":252,"lon":251},[255],{"name":256,"role":34,"phone":257,"phoneExt":26,"email":258},"Bingchen Liu, MD","0571-87783777","liubingchen111@zju.edu.cn",{"type":260,"investigatorFullName":26,"investigatorTitle":26,"investigatorAffiliation":26,"oldNameTitle":26,"oldOrganization":26},"SPONSOR","100595367","effectiveness-of-an-ai-enabled-stratified-management-system-for-premature-coronary-artery-disease-100595367",false,"NCT07031531","Effectiveness of an AI-Enabled Stratified Management System for Premature Coronary Artery Disease","Effectiveness of an AI-Enabled Stratified Management System for Premature Coronary Artery Disease (SMART-CHD): A Prospective, Multicenter, Open-Label, Randomized Controlled Trial","SMART-CHD","Inclusion Criteria\n\n1. Patients with coronary heart disease aged 18-45 years;\n2. The patient or a close family member is capable of using a smartphone and mobile application (App);\n3. Willing to participate in the study and able to provide written informed consent.\n\nExclusion Criteria\n\n1. Severe cognitive impairment;\n2. Advanced-stage malignancy;\n3. Life expectancy less than 12 months;\n4. Severe multi-organ failure;\n5. Refusal to provide written informed consent.","ALL","18 Years","45 Years",{"count":273,"type":274},4900,"ESTIMATED","INTERVENTIONAL",[277],"NA","The goal of this clinical trial is to learn if an AI-enabled stratified management system (SMART-CHD) can improve post-discharge outcomes in adults aged 18-45 with premature coronary artery disease. The main questions it aims to answer are:\n\n1. Does SMART-CHD reduce the combined rate of all-cause death, myocardial infarction, stroke and rehospitalization within 12 months?\n2. Does SMART-CHD achieve better control of modifiable risk factors compared with usual care?\n\nResearchers will compare SMART-CHD to standard discharge management (verbal and printed instructions on medications, follow-up timelines and lifestyle advice) to see if the AI-driven platform leads to fewer adverse events and improved risk-factor profiles.\n\nParticipants will:\n\n1. Install and use the SMART-CHD mobile app after a 10-minute structured orientation session with supervised simulations.\n2. Complete regular in-app surveys on lifestyle behaviors, laboratory\u002Fimaging results and clinical events (with OCR-powered LLM assistance).\n3. Wear paired sensors for continuous monitoring of blood pressure, heart rate and other physiologic metrics.\n4. Receive automated EHR data harvesting, AI-driven voice-call reminders, and real-time CRC support via a dedicated WeChat group.\n5. Follow personalized, guideline-based risk-factor recommendations (diet, exercise, sleep, weight, smoking, alcohol, hypertension, dyslipidemia, diabetes).",[280],"Premature Coronary Heart Disease",[282,283,284,285,286],"Premature coronary heart disease","secondary prevention","long-term management","mobile health","artificial intelligence","2025-09-18",{"date":289,"type":290},"2025-09-23","ACTUAL",{"date":292,"type":290},"2025-08-08",{"date":294,"type":274},"2027-07-31",{"name":5,"class":6},16]