[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100558965":3},{"organization":4,"armGroups":7,"interventions":18,"overallOfficials":23,"centralContacts":24,"locations":23,"responsibleParty":34,"collaborators":23,"id":38,"slug":39,"hasResults":40,"nctId":41,"briefTitle":42,"officialTitle":43,"acronym":23,"eligibilityCriteria":44,"healthyVolunteers":45,"sex":46,"minAge":47,"maxAge":48,"enrollmentInfo":49,"targetDuration":23,"studyType":52,"phases":53,"briefSummary":55,"conditions":56,"keywords":23,"overallStatus":58,"whyStopped":23,"lastUpdateSubmitDate":59,"lastUpdatePostDateStruct":60,"startDateStruct":63,"completionDateStruct":65,"leadSponsor":67,"locationsCount":23},{"fullName":5,"class":6},"Minia University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Toothpaste containing calcium silicate nanoparticles","ACTIVE_COMPARATOR","patients with hypersensitive areas will use the calcium silicate based toothpaste",[13],"Other: toothpaste",{"label":15,"type":10,"description":16,"interventionNames":17},"Toothpaste containing sodium fluoride nanoparticles","patients with hypersensitive areas will use the sodium fluoride based toothpaste",[13],[19],{"type":6,"name":20,"description":21,"armGroupLabels":22,"otherNames":23},"toothpaste","group of patients with hypersensitive areas will use the calcium silicate toothpaste twice per day (morning and bedtime) the toothpaste will be applied uniformly using medium toothbrush to the hypersensitive surfaces for 30seconds. After that, the patient will rinse their mouth with plain water. the other group of patients will use the sodium fluoride toothpaste twice per day (morning and bedtime). The toothpaste will be applied uniformly using a medium toothbrush to the hypersensitive areas for 30 seconds after that the patients will rinse their mouth with plain water",[9,15],null,[25,30],{"name":26,"role":27,"phone":28,"phoneExt":23,"email":29},"kareem A Lotfy, Assistant Lecturer","CONTACT","01117889888","kareem.lotfy82@gmail.com",{"name":31,"role":27,"phone":32,"phoneExt":23,"email":33},"Mona I Riad, Professor","01006608683","monariad@dentistry.cu.edu.eg",{"type":35,"investigatorFullName":36,"investigatorTitle":37,"investigatorAffiliation":5,"oldNameTitle":23,"oldOrganization":23},"PRINCIPAL_INVESTIGATOR","Kareem Abd El Hamid Lotfy","Assistant Lecturer","100558965","effectiveness-of-calcium-silicate-and-sodium-fluoride-nanoparticles-in-the-management-of-dentin-hypersensitivity-100558965",false,"NCT06557980","Effectiveness of Calcium Silicate and Sodium Fluoride Nanoparticles in The Management of Dentin Hypersensitivity","Effectiveness of Calcium Silicate and Sodium Fluoride Nanoparticles in The Management of Dentin Hypersensitivity (Randomized Controlled Clinical Trial and In-Vitro Study)","Inclusion Criteria:\n\n* Hypersensitive areas on facial surfaces of the teeth (incisors, cuspids, bicuspids, and first molars with exposed cervical dentine)\n* Areas with hard tissue erosion\n* cuneiform defect, pathological abrasion.\n* Gingival recession\n* Good overall physical health\n* Age between 20 to 40 years; and provision of written informed consent\n\nExclusion Criteria:\n\n* chipped teeth\n* Defective restorations\n* fractured un displaced cuspids\n* deep dental caries\n* deep periodontal pockets\n* orthodontic appliances, dentures, or bridgework that would interfere with the evaluation of hypersensitivity.\n* periodontal surgery within the previous 6 months.\n* ongoing treatment with antibiotics and\u002For anti-inflammatory and\u002For analgesic drugs.\n* ongoing treatment for tooth hypersensitivity, pregnancy, or lactation; heavy smoking and alcohol or drug abuse.",true,"ALL","20 Years","40 Years",{"count":50,"type":51},60,"ESTIMATED","INTERVENTIONAL",[54],"NA","This study will be performed to assess the effect of inert prepared tooth paste loaded with Calcium Silicate Nanoparticles (CSNPs) and compare it to another one containing Sodium Fluoride Nanoparticles in the management of patients complaining of hypersensitivity and laboratory investigating the efficacy of CSNPs and NaFl Nps containing toothpaste in dentinal tubules occlusion.",[57],"Dentin Hypersensitivity","NOT_YET_RECRUITING","2025-05-06",{"date":61,"type":62},"2025-05-11","ACTUAL",{"date":64,"type":51},"2025-05",{"date":66,"type":51},"2025-10",{"name":5,"class":6}]