[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100639469":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":25,"centralContacts":30,"locations":25,"responsibleParty":36,"collaborators":25,"id":40,"slug":41,"hasResults":42,"nctId":43,"briefTitle":44,"officialTitle":45,"acronym":25,"eligibilityCriteria":46,"healthyVolunteers":42,"sex":47,"minAge":48,"maxAge":49,"enrollmentInfo":50,"targetDuration":25,"studyType":53,"phases":54,"briefSummary":56,"conditions":57,"keywords":61,"overallStatus":66,"whyStopped":25,"lastUpdateSubmitDate":67,"lastUpdatePostDateStruct":68,"startDateStruct":71,"completionDateStruct":73,"leadSponsor":75,"locationsCount":25},{"fullName":5,"class":6},"Acibadem University","OTHER",[8,15],{"label":9,"type":10,"description":11,"interventionNames":12},"Resistance Exercise + Tirzepatide","EXPERIMENTAL","24-week home-based progressive resistance exercise program (3 sessions\u002Fweek) using elastic bands and bodyweight exercises, combined with tirzepatide treatment and general lifestyle recommendations..",[13,14],"Other: Resistance exercise","Other: Lifestyle recommendations",{"label":16,"type":17,"description":18,"interventionNames":19},"Tirzepatide Alone","ACTIVE_COMPARATOR","Standard tirzepatide treatment with usual care and general lifestyle recommendations.",[14],[21,26],{"type":6,"name":22,"description":23,"armGroupLabels":24,"otherNames":25},"Resistance exercise","A 24-week home-based resistance exercises using elastic band and bodyweight",[9],null,{"type":6,"name":27,"description":28,"armGroupLabels":29,"otherNames":25},"Lifestyle recommendations","Lifestyle recommendations including physical activity and nutritional advice",[9,16],[31],{"name":32,"role":33,"phone":34,"phoneExt":25,"email":35},"Özgül Öztürk, Associate Professor","CONTACT","902165004185","ozgul.ozturk@acibadem.edu.tr",{"type":37,"investigatorFullName":38,"investigatorTitle":39,"investigatorAffiliation":5,"oldNameTitle":25,"oldOrganization":25},"PRINCIPAL_INVESTIGATOR","Özgül Öztürk","Associate Professor","100639469","effectiveness-of-combined-glp-1gip-dual-agonist-therapy-and-structured-exercise-on-skeletal-muscle-morphology-quality-and-physical-function-in-overweight-and-obese-individuals-100639469",false,"NCT07609160","Effectiveness of Combined GLP-1\u002FGIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and Obese Individuals","Effectiveness of Combined GLP-1\u002FGIP Dual Agonist Therapy and Structured Exercise on Skeletal Muscle Morphology, Quality, and Physical Function in Overweight and Obese Individuals: a Randomized Controlled Trial Protocol","Inclusion Criteria:\n\n* initiation of tirzepatide-based pharmacological treatment as prescribed by an endocrinology and metabolism specialist,\n* body mass index (BMI) ≥27 kg\u002Fm² and the presence of a comorbidity condition or BMI≥30 kg\u002Fm²\n* age between 18 and 65 years\n\nExclusion Criteria:\n\n* diagnosis of type 1 or type 2 diabetes mellitus\n* presence of cerebrovascular, hematological, pulmonary, rheumatological, or neurological disorders\n* current participation in a structured diet or exercise program\n* use of weight-loss medications within the past 12 months\n* history of upper or lower extremity surgery or injury within the past 6 months\n* any contraindication to resistance exercise as determined by the treating physician.","ALL","18 Years","65 Years",{"count":51,"type":52},108,"ESTIMATED","INTERVENTIONAL",[55],"NA","This randomized controlled trial aims to investigate the effects of a 24-week home-based progressive resistance exercise program combined with tirzepatide treatment on skeletal muscle mass, muscle quality, and functional capacity in overweight and obese individuals. A total of 108 participants initiating tirzepatide therapy will be randomized to either exercise plus pharmacotherapy or pharmacotherapy alone. The primary outcome is change in thigh muscle thickness and echo intensity assessed by ultrasonography.",[58,59,60],"Obesity","Sarcopenia","Overweight (Without Type 2 Diabetes) With Weight-related Comorbidities",[62,63,64,65],"exercise","physical activity","muscle","physical function","NOT_YET_RECRUITING","2026-06-03",{"date":69,"type":70},"2026-06-04","ACTUAL",{"date":72,"type":52},"2026-11-01",{"date":74,"type":52},"2028-01-01",{"name":5,"class":6}]