[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100624029":3},{"organization":4,"armGroups":7,"interventions":31,"overallOfficials":51,"centralContacts":55,"locations":64,"responsibleParty":79,"collaborators":37,"id":83,"slug":84,"hasResults":85,"nctId":86,"briefTitle":87,"officialTitle":88,"acronym":89,"eligibilityCriteria":90,"healthyVolunteers":85,"sex":91,"minAge":92,"maxAge":93,"enrollmentInfo":94,"targetDuration":37,"studyType":97,"phases":98,"briefSummary":100,"conditions":101,"keywords":105,"overallStatus":110,"whyStopped":37,"lastUpdateSubmitDate":111,"lastUpdatePostDateStruct":112,"startDateStruct":115,"completionDateStruct":117,"leadSponsor":119,"locationsCount":120},{"fullName":5,"class":6},"The University of Hong Kong","OTHER",[8,15,21,26],{"label":9,"type":10,"description":11,"interventionNames":12},"Arm 1: Aerobic Exercise + Active tDCS","EXPERIMENTAL","* Intervention 1 (Behavioral): Aerobic exercise\n* Intervention 2 (Device): Active tDCS",[13,14],"Behavioral: Aerobic Exercise","Device: Active tDCS",{"label":16,"type":17,"description":18,"interventionNames":19},"Arm 2: Aerobic Exercise + Sham tDCS","ACTIVE_COMPARATOR","* Intervention 1 (Behavioral): Aerobic exercise\n* Intervention 2 (Device): Sham tDCS",[13,20],"Device: Sham tDCS",{"label":22,"type":17,"description":23,"interventionNames":24},"Arm 3: Stretching\u002FEducation + Active tDCS","* Intervention 1 (Behavioral): Stretching\u002Feducation control\n* Intervention 2 (Device): Active tDCS",[25,14],"Behavioral: Stretching\u002FEducation Control",{"label":27,"type":28,"description":29,"interventionNames":30},"Arm 4: Stretching\u002FEducation + Sham tDCS","SHAM_COMPARATOR","* Intervention 1 (Behavioral): Stretching\u002Feducation control\n* Intervention 2 (Device): Sham tDCS",[25,20],[32,38,42,47],{"type":33,"name":34,"description":35,"armGroupLabels":36,"otherNames":37},"BEHAVIORAL","Aerobic Exercise","* Dose: 18 sessions over 6 weeks (3\u002Fweek)\n* Session duration: 45-60 minutes including warm up\u002Fcool down\n* Intensity: Moderate (target 60-75% HRR or RPE 12-15)\n* Mode: Aerobic dance\n* Delivery: Supervised by qualified staff; HR\u002FRPE logged each session\n* Rationale: Exercise improves global cognition and domains such as working memory and attention\u002Fvigilance in schizophrenia; supervision\u002Fdose relate to effect size.",[9,16],null,{"type":33,"name":39,"description":40,"armGroupLabels":41,"otherNames":37},"Stretching\u002FEducation Control","* Dose: 18 sessions over 6 weeks (3\u002Fweek)\n* Session duration: 45-60 minutes\n* Intensity: Low (HR \\\u003C40% HRR; RPE \\\u003C10)\n* Components: Stretching + standardized health education modules\n* Purpose: Attention matched control to reduce contact\u002Fexpectancy bias in non pharmacological trials.",[22,27],{"type":43,"name":44,"description":45,"armGroupLabels":46,"otherNames":37},"DEVICE","Active tDCS","* Montage: Anode F3 (left DLPFC), cathode Fp2 (right supraorbital)\n* Intensity: 2.0 mA\n* Duration: 20 minutes (30 s ramp up\u002Fdown)\n* Schedule: 18 sessions (one per visit)\n* Rationale: Frontal tDCS protocols have shown promise for cognitive deficits and working memory in schizophrenia",[9,22],{"type":43,"name":48,"description":49,"armGroupLabels":50,"otherNames":37},"Sham tDCS","• Same montage; ramp up then off (device standard sham) to mimic cutaneous sensations.",[16,27],[52],{"name":53,"affiliation":5,"role":54},"Kit Wa Chan, MD","PRINCIPAL_INVESTIGATOR",[56,60],{"name":53,"role":57,"phone":58,"phoneExt":37,"email":59},"CONTACT","852-22554489","kwsherry@hku.hk",{"name":61,"role":57,"phone":62,"phoneExt":37,"email":63},"Yifan Chen, PhD","852-22554486","yifchen@hku.hk",[65],{"facility":5,"status":37,"city":66,"state":37,"zip":37,"country":66,"countryCode":67,"cosmosGeoPoint":68,"geoPoint":73,"contacts":74},"Hong Kong","HK",{"type":69,"coordinates":70},"Point",[71,72],114.17469,22.27832,{"lat":72,"lon":71},[75,76,77],{"name":53,"role":57,"phone":58,"phoneExt":37,"email":59},{"name":61,"role":57,"phone":62,"phoneExt":37,"email":63},{"name":78,"role":54,"phone":37,"phoneExt":37,"email":37},"Jessie Lin, PhD",{"type":80,"investigatorFullName":81,"investigatorTitle":82,"investigatorAffiliation":5,"oldNameTitle":37,"oldOrganization":37},"SPONSOR_INVESTIGATOR","Kit Wa Chan","Clinical Associate Professor","100624029","effectiveness-of-exercise-alone-and-tdcsexercise-on-cognitive-function-improvement-in-patients-with-treatment-resistant-schizophrenia-100624029",false,"NCT07404319","Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant Schizophrenia","Randomised Control Trial of Effectiveness of Exercise Alone and tDCS+Exercise on Cognitive Function Improvement in Patients With Treatment Resistant Schizophrenia","TRACE","Inclusion Criteria:\n\n* DSM 5 schizophrenia-spectrum disorders\n* Treatment resistant schizophrenia: inadequate response to ≥2 antipsychotics of adequate dose\u002Fduration\n* Clinically stable ≥4 weeks\n* Able to provide informed consent\n\nExclusion Criteria:\n\n* Neurological disorder (e.g., epilepsy, stroke) or significant head injury\n* Implanted electronic devices \u002F contraindications to tDCS; scalp lesions at electrode sites\n* Medical contraindications to moderate aerobic exercise\n* Substance dependence within 3 months (except nicotine)\n* Pregnancy","ALL","18 Years","60 Years",{"count":95,"type":96},160,"ESTIMATED","INTERVENTIONAL",[99],"NA","Cognitive impairment is a major determinant of disability in schizophrenia. Aerobic exercise improves global cognition in schizophrenia, particularly working memory and attention\u002Fvigilance. Transcranial direct current stimulation (tDCS) targeting frontal regions has shown promise for cognitive deficits, including working memory improvements in some studies. This randomized 2×2 factorial trial will test the independent and combined effects of supervised aerobic exercise and prefrontal tDCS on cognition in treatment resistant schizophrenia, measured using the MATRICS Consensus Cognitive Battery (MCCB).",[102,103,104],"Schizophrenia","Treatment Resistant Schizophrenia","Cognitive Impairment",[106,107,108,109],"tDCS","aerobic exercise","cognitive function","treatment-resistant schizophrenia","NOT_YET_RECRUITING","2026-02-04",{"date":113,"type":114},"2026-02-11","ACTUAL",{"date":116,"type":96},"2026-02-23",{"date":118,"type":96},"2028-01-30",{"name":81,"class":6},1]