[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100517119":3},{"organization":4,"armGroups":7,"interventions":14,"overallOfficials":21,"centralContacts":25,"locations":31,"responsibleParty":47,"collaborators":20,"id":49,"slug":50,"hasResults":51,"nctId":52,"briefTitle":53,"officialTitle":54,"acronym":20,"eligibilityCriteria":55,"healthyVolunteers":51,"sex":56,"minAge":20,"maxAge":20,"enrollmentInfo":57,"targetDuration":20,"studyType":60,"phases":61,"briefSummary":63,"conditions":64,"keywords":20,"overallStatus":67,"whyStopped":20,"lastUpdateSubmitDate":68,"lastUpdatePostDateStruct":69,"startDateStruct":72,"completionDateStruct":74,"leadSponsor":76,"locationsCount":77},{"fullName":5,"class":6},"Second Affiliated Hospital, School of Medicine, Zhejiang University","OTHER",[8],{"label":9,"type":10,"description":11,"interventionNames":12},"self pre-and post-control","EXPERIMENTAL","It is a self pre- and post-control, which compares the outcomes of the ketogenic diet with the status that did not receive ketogenic treatment",[13],"Dietary Supplement: Ketogenic diet",[15],{"type":16,"name":17,"description":18,"armGroupLabels":19,"otherNames":20},"DIETARY_SUPPLEMENT","Ketogenic diet","Ketogenic diet (KD) is a high-fat, low-carbohydrate and moderate protein diet pattern, suitable for refractory epilepsy, glucose carrier protein 1 deficiency, pyruvate dehydrogenase deficiency, tumors and some genetic metabolic diseases. The ketogenic diet has been used to treat epilepsy for nearly 100 years, and its safety has been recognized by the medical community. In 2015, the ketogenic diet was included in the \"Clinical Diagnosis and Treatment Guidelines - Epilepsy Volume\" and became a commonly used treatment for refractory epilepsy.",[9],null,[22],{"name":23,"affiliation":5,"role":24},"Shuang Wang, doctor","PRINCIPAL_INVESTIGATOR",[26],{"name":27,"role":28,"phone":29,"phoneExt":20,"email":30},"Yao Ding, doctor","CONTACT","13588015954","zjdingyao@zju.edu.cn",[32],{"facility":5,"status":20,"city":33,"state":34,"zip":35,"country":36,"countryCode":37,"cosmosGeoPoint":38,"geoPoint":43,"contacts":44},"Hangzhou","Zhejiang","310000","China","CN",{"type":39,"coordinates":40},"Point",[41,42],120.16142,30.29365,{"lat":42,"lon":41},[45],{"name":27,"role":28,"phone":46,"phoneExt":20,"email":30},"13588015854",{"type":48,"investigatorFullName":20,"investigatorTitle":20,"investigatorAffiliation":20,"oldNameTitle":20,"oldOrganization":20},"SPONSOR","100517119","effectiveness-of-ketogenic-diet-in-melas-syndrome-100517119",false,"NCT06013397","Effectiveness of Ketogenic Diet in MELAS Syndrome","Clinical Trial of Ketogenic Diet in the Treatment of Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-like Episodes(MELAS)","Inclusion Criteria:\n\n* Patients who meet the diagnostic criteria of MELAS and have received MELAS standard therapy but are not satisfied with the therapeutic effect, and voluntarily underwent ketogenic therapy\n\nExclusion Criteria:\n\n* Diseases with porphyria and disturbances in fatty acid transport and oxidation, severe electrolyte metabolism abnormalities, severe hemodynamic instability, acute respiratory infections, uncontrolled systemic infections, severe liver and renal failure, cholesterolemia (\\>300mgdl), abnormal coagulation, acute pancreatitis, eating disorders, ketogenic diet intolerance, significant weight loss, poor compliance","ALL",{"count":58,"type":59},100,"ESTIMATED","INTERVENTIONAL",[62],"NA","The goal of this clinical trial is to evaluate the effectiveness of ketogenic diet in patients with MELAS syndrome. The main questions it aims to answer are:\n\nClarify the curative effects of ketogenic diet in the treatment of MELAS disease.\n\nPrevent the aggravation of MELAS disease, and improve the quality of life of patients.\n\nProvide reliable evidence-based medical basis for the clinical application of ketogenic diet in the treatment of MELAS syndrome patients.\n\nThe clinical data of the participants treated with ketogenic diet will be collected, including the completion of ketogenic diet and clinical data at the start of treatment and after 1 month, 3 months, 6 months and 12 months",[65,66],"MELAS Syndrome","Ketogenic Dieting","NOT_YET_RECRUITING","2023-08-25",{"date":70,"type":71},"2023-08-28","ACTUAL",{"date":73,"type":59},"2023-09-01",{"date":75,"type":59},"2038-06-01",{"name":5,"class":6},1]