[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"health-study-detail:100640272":3},{"organization":4,"armGroups":7,"interventions":20,"overallOfficials":26,"centralContacts":31,"locations":37,"responsibleParty":56,"collaborators":60,"id":76,"slug":77,"hasResults":78,"nctId":79,"briefTitle":80,"officialTitle":81,"acronym":82,"eligibilityCriteria":83,"healthyVolunteers":78,"sex":84,"minAge":85,"maxAge":26,"enrollmentInfo":86,"targetDuration":26,"studyType":89,"phases":90,"briefSummary":92,"conditions":93,"keywords":97,"overallStatus":102,"whyStopped":26,"lastUpdateSubmitDate":103,"lastUpdatePostDateStruct":104,"startDateStruct":107,"completionDateStruct":109,"leadSponsor":111,"locationsCount":112},{"fullName":5,"class":6},"Vietnam Military Medical University","OTHER",[8,14],{"label":9,"type":10,"description":11,"interventionNames":12},"Study group (CA0)","EXPERIMENTAL","Sperm preparation using LensHooke® CA0 live motile sperm sorting device.",[13],"Device: LensHooke® CA0 sperm sorting device",{"label":15,"type":16,"description":17,"interventionNames":18},"Control group (DGC)","ACTIVE_COMPARATOR","Conventional sperm preparation using density gradient centrifugation.",[19],"Device: Density Gradient Centrifugation",[21,27],{"type":22,"name":23,"description":24,"armGroupLabels":25,"otherNames":26},"DEVICE","LensHooke® CA0 sperm sorting device","Sperm will be processed using the CA0 device by loading 1.0 mL of semen into the lower chamber and adding 0.9 mL of pre-equilibrated sperm washing medium into the upper chamber.\n\nThe device is incubated at 37 °C for a minimum of 30 minutes, followed by aspirating 0.5 mL of recovered sperm suspension for ICSI.",[9],null,{"type":22,"name":28,"description":29,"armGroupLabels":30,"otherNames":26},"Density Gradient Centrifugation","Sperm will be prepared by layering 1 mL of 45% medium and 1 mL of 90% medium with 1 mL of semen sample.\n\nThis is followed by a first centrifugation at 1500 rpm for 15 minutes, a wash step using 2 mL G-IVF plus medium, and a second centrifugation at 1200 rpm for 10 minutes to retain 0.5 mL of the sperm suspension.",[15],[32],{"name":33,"role":34,"phone":35,"phoneExt":26,"email":36},"Son The Trinh","CONTACT","+ 84 902150873","trinhtheson@vmmu.edu.vn",[38],{"facility":39,"status":26,"city":40,"state":41,"zip":42,"country":43,"countryCode":44,"cosmosGeoPoint":45,"geoPoint":50,"contacts":51},"Vietnam Military medical university","Hà Nội","Ha Dong","100000","Vietnam","VN",{"type":46,"coordinates":47},"Point",[48,49],106.02292,20.47366,{"lat":49,"lon":48},[52],{"name":53,"role":34,"phone":54,"phoneExt":26,"email":55},"Phuong Minh Nguyen, M.D","0963048428","nguyenminhphuongk53@vmmu.edu.vn",{"type":57,"investigatorFullName":58,"investigatorTitle":59,"investigatorAffiliation":5,"oldNameTitle":26,"oldOrganization":26},"PRINCIPAL_INVESTIGATOR","Trinh The Son","M.D., PhD., Associate Prof",[61,63,65,68,70,72,74],{"name":62,"class":6},"National Hospital of Obstetrics and Gynecology",{"name":64,"class":6},"Tam Anh TP. Ho Chi Minh General Hospital",{"name":66,"class":67},"Viet-Belgium Andrology and Infertility Hospital","UNKNOWN",{"name":69,"class":67},"Phuong Chau International Hospital",{"name":71,"class":67},"Dong Do Hospital",{"name":73,"class":6},"Vinmec Healthcare System",{"name":75,"class":6},"Andrology and Fertility Hospital of Hanoi","100640272","effectiveness-of-live-motile-sperm-sorting-device-on-ivf-outcomes-in-advanced-paternal-age-100640272",false,"NCT07605182","Effectiveness of Live Motile Sperm Sorting Device on IVF Outcomes in Advanced Paternal Age","Evaluation of the Effectiveness of Live Motile Sperm Sorting Device on In Vitro Fertilization Outcomes in Advanced Paternal Age Group","IVF","Inclusion Criteria:\n\n* Male partners aged ≥ 40 years\n* Semen analysis: volume ≥ 1.4 mL, sperm concentration ≥ 6 million\u002FmL, progressive motility (PR) ≥ 20% after 3-5 days of abstinence.\n* Female partners with ≥ 5 mature (MII) oocytes retrieved.\n* Couples undergoing ICSI with PGT-A and elective single embryo transfer (eSET).\n* Willingness to participate and sign informed consent.\n\nExclusion Criteria:\n\n* Azoospermia, surgical sperm retrieval, or use of cryopreserved sperm.\n* Female uterine or ovarian conditions severely affecting IVF outcomes.\n* Use of donor sperm or donor oocytes","ALL","40 Years",{"count":87,"type":88},378,"ESTIMATED","INTERVENTIONAL",[91],"NA","Male infertility contributes significantly to infertility, particularly in advanced paternal age men where sperm DNA fragmentation is increased. Conventional density gradient centrifugation may induce oxidative stress and sperm damage. LensHooke® CA0 is a centrifugation-free sperm sorting device designed to improve sperm quality and reduce DNA fragmentation. This prospective comparative study evaluates the effectiveness of CA0 versus conventional density gradient centrifugation on post-processing sperm quality, DNA fragmentation index, blastocyst formation, euploid embryo rate, and clinical pregnancy outcomes in IVF\u002FICSI cycles involving men aged 40 years or older",[94,95,96],"Male Infertility","Advanced Paternal Age","Assisted Reproductive Technology",[98,99,100,101],"DNA fragmentation","Advanced paternal age","ICSI","LensHooke CA0","NOT_YET_RECRUITING","2026-05-19",{"date":105,"type":106},"2026-05-22","ACTUAL",{"date":108,"type":88},"2026-05-05",{"date":110,"type":88},"2027-12-30",{"name":5,"class":6},1]